Influence of gender on the distribution of type 2 diabetic complications at the obafemi awolowo teaching hospital, Ile-Ife, Nigeria

Enikuomehin, Adenike; Kolawole, Babatope; Soyoye, Olubukunmi D; Adebayo, Joseph O.; Ikem, Rosemary

doi:10.4314/ahs.v20i1.35

Cited by 6 publications

(4 citation statements)

References 45 publications

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“…Obesity and hypertension were more common in women. Contrary to earlier data [ 27 ], males were more likely than women to accomplish LDL treatment targets in type 2 DM in Nigeria (69.5% vs 59.0%, p<0.05). However, the mean total cholesterol was considerably greater in women; this conflicts with former research, on type 2 DM in Nigeria [ 28 ].…”

Section: Discussioncontrasting

confidence: 95%

Overall Clinical Features of Type 2 Diabetes Mellitus With Respect to Gender

Ali¹,

Haider²,

Ali³

et al. 2023

Cureus

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IntroductionSince patients with type 2 diabetes are frequently misdiagnosed, provided inappropriate management, or poorly controlled, it is important to comprehend the wide range of clinical signs and symptoms associated with diabetes. Therefore, this study evaluated the overall clinical manifestations of patients with type 2 diabetes patients with respect to gender. MethodsThis was a multicenter, cross-sectional study that was conducted at various hospitals, using a nonprobability sampling technique. The duration of the study was about six months, from January 1, 2022 to June 30, 2022. The study included 590 type 2 diabetes patients, ranging in age from 35 to 70 years. Age, gender, socioeconomic status, health status, co-morbidities, and diabetes symptoms were documented. A chi-square was applied to determine the association between overall symptoms associated with type 2 diabetes and gender. An independent t-test was applied to determine the significance level between means of demographic parameters. ResultsThe study findings showed that out of 590 patients with diabetes, 310 (52.5%) were males and 280 (47.5%) were females. The male and female mean ages were 57.46±14.93 and 50.38±14.85 years, respectively, with a statistically significant gender difference (p<0.001). The prevalence of renal manifestation in type 2 patients with diabetes revealed a significant relationship (p<0.05) for both genders. The prevalence of ocular manifestations revealed a significant relationship with both genders (p<0.05) in terms of distortion and blurred vision. The prevalence of ocular manifestations revealed a significant relationship observed with both genders (p<0.05) in terms of shortness of breath, dyspnea severity, and severity of chest pain. ConclusionThis study concluded that women with type 2 diabetes mellitus have a significantly higher frequency of muscular pain, urinary symptoms, neurological symptoms, and dermatological manifestations than men. In contrast, respiratory symptoms were significantly more pronounced in males than in females. The presence of comorbidities such as dyslipidemia significantly increased the probability of developing type 2 diabetes in both genders.

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Section: Discussioncontrasting

confidence: 95%

Overall Clinical Features of Type 2 Diabetes Mellitus With Respect to Gender

Ali¹,

Haider²,

Ali³

et al. 2023

Cureus

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“…This gender difference may be related to factors such as sex hormones, glucose balance, and body composition. 33 , 34 First, in older adults, Fetuin-A (a protein primarily secreted by the liver that regulates insulin signaling) levels are higher in women than in men, increasing the former’s risk of T2DM. 35 Second, a decline in sex hormone levels can aggravate the impaired glucose metabolism of women as they age.…”

Section: Discussionmentioning

confidence: 99%

“… 35 Second, a decline in sex hormone levels can aggravate the impaired glucose metabolism of women as they age. 33 Third, higher androgen activity may be present after menopause in women, resulting in impaired glucose tolerance and the promotion of insulin resistance. 36 Finally, older men have high concentrations of anabolic hormones, which stimulate muscle protein synthesis by increasing lean muscle mass, leading to greater strength than in women.…”

Section: Discussionmentioning

confidence: 99%

Gender-Specific Association of Handgrip Strength with Type 2 Diabetes Mellitus in Chinese Han Older Adults

Huang¹,

Chen²,

Shen³

et al. 2023

DMSO

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Purpose We aimed to analyze the relationship between handgrip strength/relative handgrip strength among older Han adults with type 2 diabetes mellitus (T2DM) by gender to determine the optimal cut-off value of grip strength for older adults. Methods A multi-stage sampling method was used to conduct a questionnaire survey and physical examination of 6128 older adults in Anhui Province. Chi-squares tests, t -tests, analysis of variance, and logistic regression analysis were used to analyze the association between handgrip strength/relative handgrip strength and T2DM between the sexes. The decision tree model (CRT) was used to explore the predictive value of handgrip strength /relative handgrip strength on T2DM. Results There was an association between handgrip strength and T2DM ( P = 0.006, OR = 0.985, 95% CI = 0.975, 0.996), which was found in females ( P = 0.013, OR = 0.978, 95% CI = 0.961, 0.995) but not in males ( P = 0.125, OR = 0.989, 95% CI = 0.976, 1.003). Relative handgrip strength was also correlated with T2DM ( P = 0.014, OR = 0.730, 95% CI = 0.568, 0.939), which was found in females ( P = 0.003, OR = 0.534, 95% CI = 0.352, 0.809) but not in males ( P = 0.432, OR = 0.879, 95% CI = 0.638, 1.212). The incidence of T2DM in elderly females with hypertension who were uneducated and with a handgrip strength of <17.350 kg was 24.3% (115 cases), whereas that in elderly females with hypertension and a relative handgrip strength of <0.240 was 29.0% (127 cases). Conclusion According to our results, handgrip strength and relative handgrip strength were associated with T2DM. People with hypertension had a higher risk of T2DM in women with a handgrip strength of ≤ 17.350kg and a relative grip strength of ≤ 0.240. Further research is needed to validate the effectiveness of this cut-off for implementing interventions and avoiding risks.

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“…In a longitudinal study, patients with baseline hypertension or even prehypertension had an increased risk of developing diabetes mellitus than normotensive subjects [ 8 ]. Furthermore, increasing evidence demonstrates that severe macrovascular and microvascular complications are more likely to occur in diabetic patients with hypertension [ 9 , 10 ]. However, the risk factors for the development of hypertension and their relative importance in T2DM are not well characterized, limiting the effectiveness of efforts to identify and treat at-risk individuals.…”

Section: Introductionmentioning

confidence: 99%

Liver indicators affecting the relationship between BMI and hypertension in type 2 diabetes: a mediation analysis

Yao,

Hu,

Wang

et al. 2024

Diabetol Metab Syndr

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Background Body mass index (BMI) is an important risk factor for hypertension in diabetic patients. However, the underlying mechanisms remain poorly understood. Although liver-derived biological intermediates may play irreplaceable roles in the pathophysiology of diabetes, few studies have explored them in the association between BMI and hypertension in diabetes. Objective To investigate the role of liver enzymes in mediating the relationship between BIM exposure and hypertension in type 2 diabetes mellitus (T2DM). Methods We included a total of 1765 participants from the China National Diabetic Chronic Complications Study Cohort. Associations between liver enzymes and hypertension were estimated using multivariable regression models. The function of liver indicators in the relationship between BMI and hypertension was assessed using mediation analysis. Mediation analysis was conducted, taking into account age, diabetes duration, current smoking, fasting plasma glucose level, glycated hemoglobin, anti-diabetic therapy, and family history of diseases, including diabetes, hypertension, obesity, and hyperlipidemia. Results For men, the association of BMI with hypertension was partially mediated by alanine aminotransferase (ALT), with a proportion of mediation was 68.67%, by aspartate aminotransferase (AST) was 27.02%, and by γ-glutamyltransferase (GGT) was 38.58%, by AST/ALT was 63.35%; for women, the proportion mediated by ALT was 36.93%, and by AST was 37.47%, and GGT was 44.60%, and AST/ALT was 43.73% for BMI (all P < 0.05). Conclusion The effect of BMI on hypertension is partly mediated by liver indicators (ALT, AST, GGT, and AST/ALT) in diabetic patients. Our results may provide opportunities to identify new targets for hypertension interventions.

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Influence of gender on the distribution of type 2 diabetic complications at the obafemi awolowo teaching hospital, Ile-Ife, Nigeria

Cited by 6 publications

References 45 publications

Overall Clinical Features of Type 2 Diabetes Mellitus With Respect to Gender

Overall Clinical Features of Type 2 Diabetes Mellitus With Respect to Gender

Gender-Specific Association of Handgrip Strength with Type 2 Diabetes Mellitus in Chinese Han Older Adults

Liver indicators affecting the relationship between BMI and hypertension in type 2 diabetes: a mediation analysis

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