Influence of gender on assessments of disease activity and function in early rheumatoid arthritis in relation to radiographic joint damage

Ahlmén, Monica; Svensson, Björn; Albertsson, Kristina; Forslind, Kristina; Hafström, Ingiäld

doi:10.1136/ard.2008.102244

Cited by 129 publications

(112 citation statements)

References 16 publications

(16 reference statements)

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“…In particular, we were unable to adjust for the severity of comorbid conditions. Our findings add further support to previous studies that reported a more favorable outcome for male RA patients compared to female RA patients (2)(3)(4)(5)(6)(7)(8)(9)(10)(11). We have also highlighted the importance of examining such questions using longitudinally collected data, and with the aid of novel analytical techniques.…”

Section: Discussionsupporting

confidence: 88%

“…For example, it is possible that men and women perceive pain differently (10), that male patients may be better at compensating for disability than female patients (9), or that men may underreport their disability. The sex differences we found did not change with time, suggesting that varying "time to compensation for disability" is not an explanation for the findings.…”

Section: Discussionmentioning

confidence: 99%

“…It has also been reported that, compared to men, women have a poorer outcome in terms of functional outcome and disease activity (2)(3)(4)(5)(6)(7)(8)(9)(10)(11), although no sex difference in terms of radiographic damage has been reported (5,10).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Influence of age and sex on functional outcome over time in a cohort of patients with recent‐onset inflammatory polyarthritis: Results from the Norfolk arthritis register

Camacho¹,

Verstappen²,

Lunt³

et al. 2011

Arthritis Care & Research

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Objective. It has been found that women with rheumatoid arthritis (RA) have a poorer prognosis than men. However, the impact of age at symptom onset is unclear. We investigated the relationship between these factors and functional disability in patients with recent-onset inflammatory polyarthritis (IP). Methods. A total of 3,666 patients (66% women) were registered with the Norfolk Arthritis Register between 1990 and 2008. Functional disability was assessed using the Health Assessment Questionnaire (HAQ), adjusted for age at HAQ completion. Linear random-effects models were used to examine HAQ score over time, by sex and age at symptom onset (early ‫؍‬ age <55 years, late ‫؍‬ age 55-74 years, very late ‫؍‬ age >75 years). Results. Women had higher HAQ scores over time than men (mean difference 0.29; 95% confidence interval [95% CI] 0.25, 0.34). Men with late-onset IP had lower baseline HAQ scores than men with early onset (mean difference ؊0.14; 95% CI ؊0.29, ؊0.001). Women had comparable baseline HAQ scores at all ages of onset. Both sexes showed the greatest rate of disability progression in patients with very late onset. Those with early onset had a steady level of disability over time. Adjustment for treatment received, comorbidities, and RA subgroup analysis produced results that were largely similar to the initial analysis. Conclusion. Female patients have higher HAQ scores than male patients; patients with early symptom onset show the smallest sex difference. Older age at symptom onset is associated with an increasingly steep trajectory of disability progression. The impact of sex on outcome is evident at baseline, whereas the impact of age at symptom onset becomes apparent during long-term followup.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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Influence of age and sex on functional outcome over time in a cohort of patients with recent‐onset inflammatory polyarthritis: Results from the Norfolk arthritis register

Camacho¹,

Verstappen²,

Lunt³

et al. 2011

Arthritis Care & Research

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“…One explanation is a difference in perception of functional disability, where males underestimate their disability (46). Almost a quarter of patients admitted poor adherence to their DMARD medication, and these patients fared worse.…”

Section: Discussionmentioning

confidence: 99%

Functional disability and health-related quality of life in South Africans with early rheumatoid arthritis

Hodkinson

Musenge

Ally

et al. 2012

Scandinavian Journal of Rheumatology

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“…Rheumatoid arthritis (RA) is a chronic disease where limitations and restrictions in everyday life are commonly experienced [1][2][3][4][5][6]. Medications for RA have developed greatly during the past century [7], and new biological agents have extensively reduced disability due to RA [8].…”

Section: Introductionmentioning

confidence: 99%

Emotions related to participation restrictions as experienced by patients with early rheumatoid arthritis: a qualitative interview study (the Swedish TIRA project)

et al. 2014

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Influence of gender on assessments of disease activity and function in early rheumatoid arthritis in relation to radiographic joint damage

Abstract: Despite a similar degree of radiographic joint destruction women had, compared with men, worse scores for DAS28 and HAQ, possibly due to higher pain perception and less muscular strength and perhaps because men overestimate their functional capacity.

Cited by 129 publications

References 16 publications

Influence of age and sex on functional outcome over time in a cohort of patients with recent‐onset inflammatory polyarthritis: Results from the Norfolk arthritis register

Influence of age and sex on functional outcome over time in a cohort of patients with recent‐onset inflammatory polyarthritis: Results from the Norfolk arthritis register

Functional disability and health-related quality of life in South Africans with early rheumatoid arthritis

Emotions related to participation restrictions as experienced by patients with early rheumatoid arthritis: a qualitative interview study (the Swedish TIRA project)

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