Influence of gender and menopause on gastric emptying and motility

Hutson, William R.; Roehrkasse, Richard L.; Wald, Arnold

doi:10.1016/0016-5085(89)90758-0

Cited by 272 publications

(171 citation statements)

References 25 publications

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“…Postmenopausal women on hormone replacement therapy exhibited a delay in gastric emptying similar to that observed in premenopausal women (13) . Reduced gastrointestinal smooth muscle contractility has been attributed to the presence of female reproductive hormones (3) .…”

Section: -Out/dez 2009supporting

confidence: 51%

“…Identidade de gênero. oropharyngeal transit (9) , UES opening duration (17,22) , pressure duration in the oropharynx with swallows (19) , duration of distal esophageal contractions (6) , and gastric emptying of solid food (13,15) . These results showed that women have a longer transit, contraction duration, UES opening and gastric emptying than men.…”

Section: -Out/dez 2009mentioning

confidence: 99%

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Gender differences in proximal esophageal contractions

Dantas

Alves

Cassiani

2009

Arq. Gastroenterol.

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-Context -There are reports showing that gender has an influence on swallowing and on the contractions of the distal esophageal body. Objective -In this investigation we studied the effect of gender on proximal esophageal contraction. Methods -We studied 20 men (22-68 years old, median 39 years) and 44 women (18-61 years old, median 41 years) without symptoms and without gastrointestinal or respiratory diseases. We measured the time interval between the onset of pharyngeal contraction 1 cm proximal to the upper esophageal sphincter and the onset of the proximal esophageal contraction 5 cm from the pharyngeal recording. We also measured the amplitude, duration and area under the curve of the proximal esophageal contractions. The recording was performed by the manometric method with continuous perfusion. The contractions were recorded in duplicate after swallows of a 5 mL bolus of water. Results -There were no differences between men and women in the interval between the onset of pharyngeal and of esophageal contractions or in the amplitude of esophageal contractions. The duration of contractions was longer in women (2.35 ± 0.60 s) than in men (2.07 ± 0.62 s) but the difference did not reach statistical significance (P = 0.087). The area under the curve of the esophageal contraction was higher in women (130.2 ± 55.2 mm Hg x s) than in men (97.4 ± 49.4 mm Hg x s, P = 0.026). Conclusion -We conclude that there is a difference between men and women in the proximal esophageal contractions in response to wet swallows, although this difference is of no clinical relevance.

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Section: -Out/dez 2009supporting

confidence: 51%

Section: -Out/dez 2009mentioning

confidence: 99%

Gender differences in proximal esophageal contractions

Dantas

Alves

Cassiani

2009

Arq. Gastroenterol.

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“…We thus examined the GIP and GLP-1 responses to oral glucose in a homogenous group of postmenopausal women belonging to a population with a prevalent degree of IGT (23). Also, we selected women for the study to avoid the well-known sex influence of gastric emptying (20)(21)(22).…”

Section: Discussionmentioning

confidence: 99%

“…We have therefore, in this study, examined the GIP and GLP-1 plasma responses to an oral glucose load in a homogenous group of postmenopausal women with IGT in comparison with an age-and weight-matched control group with normal glucose tolerance (NGT). The study was undertaken in subjects of the same sex, to avoid the previously described sexdependent difference in gastric emptying (20)(21)(22), and we studied women of an age group with a high preponderance of IGT and thereby an increased risk for the development of NIDDM (23).…”

Section: Introductionmentioning

confidence: 99%

Reduced gastric inhibitory polypeptide but normal glucagon-like peptide 1 response to oral glucose in postmenopausal women with impaired glucose tolerance

Åhrén

Larsson

Holst³

1997

European Journal of Endocrinology

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Objective: The gastrointestinal hormones, gastric inhibitory polypeptide (GIP) and glucagon-like peptide 1 (GLP-1), are both released from the gut after oral glucose ingestion and stimulate insulin secretion. This study examined the release of these hormones in subjects with impaired glucose tolerance (IGT), which precedes the development of non-insulin-dependent diabetes. Design and methods: Six postmenopausal women with IGT, aged 59 years, underwent a 75 g oral glucose tolerance test and plasma levels of GIP and GLP-1 were determined regularly during the following 2 h. The results were compared with those in seven age-and weight-matched women with normal glucose tolerance (NGT). Results: Basal plasma levels of GIP and GLP-1 were not different between the groups. In response to the oral glucose ingestion, plasma levels of both GIP and GLP-1 increased in both groups. The plasma GIP increase after glucose ingestion was, however, reduced in women with IGT. Thus, the GIP response as determined as the area under the curve for the 60 min after oral glucose was 34.8 Ϯ 3.2 pmol/l per min in women with IGT versus 56.4 Ϯ 7.8 pmol/l per min in those with NGT (P ¼ 0.021). In contrast, the GLP-1 response to oral glucose was not different between the groups. By definition, the glucose response to oral glucose was markedly increased in women with IGT, and the insulin response during the second hour after glucose ingestion was exaggerated. Conclusions:The GIP response to oral glucose is impaired in postmenopausal women with IGT, whereas the plasma GLP-1 response is not affected.

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“…Com a menopausa este efeito tenderia a desaparecer e as taxas de EG a se igualar 11 . O efeito da idade no EG tem sido pouco estudado e os resultados não são uniformes.…”

Section: Discussionunclassified

Esvaziamento gástrico nos pacientes com insuficiência renal crônica submetidos à hemodiálise

Hirata¹,

Mesquita²,

Camargo³

et al. 2008

ABCD, arq. bras. cir. dig.

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INTRODUÇÃOQueixas dispépticas são comuns em pacientes com insuficiência renal crônica (IRC). As mais frequentemente relatadas são anorexia, náusea, vômito, sensação de plenitude gástrica e dor epigástrica 20 . A possibilidade destes sinais e sintomas estarem associadas a retardo no esvaziamento gástrico (EG) é atraente 8 e não faltam, no paciente urêmico, causas para explicar esta disfunção: acidose metabólica, anemia 16 e neuropatia 2 . Desde a observação de Goldstein, de retardo no EG em urêmicos em 1986, vários trabalhos têm apresentado resultados bastante conflitantes 5 . Falta de padronização das refeições testes, da gravidade e do tipo de tratamento da IRC e do método de estudo do EG poderiam explicar os diferentes resultados encontrados na literatura.A importância do EG em anestesia pode ser resumida em um de seus aspectos principais: o jejum pós-operatório. Retardo pode causar estase gástrica, predispondo ao risco de vômito e aspiração 12 . A importância clínica pode ser entendida se nos detivermos ao grande enfoque que se tem dado aos transplantes renais, como principal forma de tratamento da IRC. Medidas especiais na indução e recuperação da anestesia são recomendadas, com o intuito de evitar as graves complicações pulmonares que podem ocorrer nas situações de distúrbios do EG 7 .O objetivo deste estudo foi estudar o EG em pacientes com IRC em tratamento hemodialítico e compará-lo a um grupo de individuo sadios, utilizando-se o método da cintilografia gástrica. MÉTODOEste trabalho foi aprovado pelo Comitê de Ética em Pesquisa da Faculdade de Ciências Médicas da Unicamp com o termo de consentimento tendo sido assinado na entrevista, quando o paciente era convidado a participar da pesquisa, após esclarecimentos sobre o estudo Foram estudados 14 pacientes com IRC em tratamento hemodialítico há mais de seis meses no Hospital das Clíni-cas da Unicamp (Grupo THD). Os critérios de exclusão foram presença de diabete melito, amiloidose, doenças do colágeno, úlcera péptica, cirurgia gástrica prévia e gravidez. Nenhum deles estava em uso de medicações que pudessem afetar a motilidade gastrintestinal.O grupo-controle (CTL) foi constituído por 18 vol- Trabalho realizado no Hospital de Clínicas da Faculdade de Ciências Médicas da Universidade Estadual de Campinas -UNICAMP, Campinas, SP, Brasil C o r re s p o n d ê n c i a : E u n i c e S i z u e H i r a t a , e -m a i l :eshirata@hotmail.com ABCDDV/607

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Influence of gender and menopause on gastric emptying and motility

Cited by 272 publications

References 25 publications

Gender differences in proximal esophageal contractions

Gender differences in proximal esophageal contractions

Reduced gastric inhibitory polypeptide but normal glucagon-like peptide 1 response to oral glucose in postmenopausal women with impaired glucose tolerance

Esvaziamento gástrico nos pacientes com insuficiência renal crônica submetidos à hemodiálise

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