Influence of Gelatinase B Polymorphic Variants and Its Serum Levels in Atherosclerosis

Spurthi, Kondapalli Mrudula; Galimudi, Rajesh Kumar; Gantala, Srilatha Reddy; Sahu, Sushanta Kumar; Nallari, Pratibha; Hanumanth, Surekha Rani

doi:10.1089/gtmb.2011.0299

Cited by 9 publications

(5 citation statements)

References 23 publications

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“…It has been observed that the levels of serum MMP-9 were elevated in patients with coronary atherosclerosis (Spurthi et al, 2012) and that there was an association between the levels of circulating MMP-9 and cardiovascular events and mortality (Blankenberg et al, 2003;Weiss et al, 2010). Opstad et al (2012) reported that in T-allele carriers, mRNA levels were 1.7-fold lower compared to wild-type CC.…”

Section: Introductionmentioning

confidence: 99%

Association of Genetic Polymorphisms in Matrix Metalloproteinase-9 and Coronary Artery Disease in the Chinese Han Population: A Case–Control Study

Bai

Chen

et al. 2013

Genetic Testing and Molecular Biomarkers

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Objective: Matrix metalloproteinase-9 (MMP-9) plays an important role in inflammation and matrix degradation involved in atherosclerosis and plaque rupture. The T allele of rs3918242 has been reported to lead to a high promoter activity and associate with the extent of coronary artery disease (CAD). And some studies have reported that the G allele of rs17576 might be associated with CAD. The aim of this study was to assess the association between the polymorphisms of the MMP-9 gene and CAD in the Chinese Han population. Methods: This case-control study comprised 258 CAD cases and 153 controls from the Chinese Han Population. The genomic DNA of MMP-9 was isolated from whole blood. Polymerase chain reaction-based restriction fragment length polymorphism was used to determine the rs3918242 and rs17576 genotypes in the MMP-9 gene and the total serum levels of MMP-9 were measured using enzyme-linked immunosorbent assay in both case and control groups. Results: Analysis of MMP-9 gene polymorphisms showed that the frequencies of the T allele and CT + TT genotypes of rs3918242 were significantly higher in the case group than in the control group ( p < 0.05). However, the distribution of variant genotypes of rs17576 did not differ between the case and control groups ( p > 0.05). The total serum level of MMP-9 was significantly higher in the case group than in the control group ( p < 0.05). The subjects carrying T alleles in the CAD group had higher average serum MMP-9 levels compared with CC genotypes ( p < 0.05). Conclusions: Our results suggest that the single-nucleotide polymorphism of rs3918242 in the MMP-9 gene is associated with CAD and high serum levels of MMP-9 are also associated with CAD in the Chinese Han population. Therefore, genetic variation of rs3918242 may participate in the development of CAD through influencing MMP-9 expression.

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Section: Introductionmentioning

confidence: 99%

Association of Genetic Polymorphisms in Matrix Metalloproteinase-9 and Coronary Artery Disease in the Chinese Han Population: A Case–Control Study

Bai

Chen

et al. 2013

Genetic Testing and Molecular Biomarkers

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“…Again, Spurthi and colleagues also found a high level of serum gelatinase B in patients with coronary artery. They have reported that their findings not only are relevant to the understanding of the pathogenesis of atherosclerosis but also may provide a novel target for future development of predictive, preventive, and therapeutic measures [15]. Kalale et al [16] said that there are findings to indicate that arterial inflammation is reflected in increased serum concentration of gelatinase B and since gelatinase B has been suggested to reflect inflammation in atherosclerotic plaques, it may be useful in the evaluation of the severity of cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

“…Gelatinase B enzymatically active in atherosclerotic plaques, and are known to be associated with the progression and development of atherosclerotic lesions [9][10][11][12]. Studies have reported that gelatinase B associated with coronary artery disease [10,[13][14][15][16][17]. Coronary artery disease, can be prevented or significantly delayed, has been reported to be a disease [18].…”

Section: Introductionmentioning

confidence: 99%

Relationship of Gelatynase B Enzyme Activity and Coronary Artery Disease

Bayramoglu¹

2018

BBOAJ

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“…The genetic analysis of the MMP-9-1562C/T polymorphism showed a higher frequency of the allele T in patients with coronary heart disease, vs. the control group ( Wu et al, 2013 ). It was also demonstrated that the increased MMP-9 levels in people with the allele T contributes to the exacerbation of the atherosclerosis and coronary artery stenoses ( Spurthi et al, 2012 ). The recent meta-analysis showed that CT and TT genotypes were associated with the increased risk of coronary heart disease when compared to the CC genotype.…”

Section: Introductionmentioning

confidence: 99%

Does the functional polymorphism-1562C/T of MMP-9 gene influence brain disorders?

Pabian‐Jewuła

Rylski

2023

Front. Cell. Neurosci.

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Metalloproteinase-9 (MMP-9) is one of the most strongly expressed matrix metalloproteinases (MMPs) in the brain. The MMP-9 activity in the brain is strictly regulated, and any disruptions in this regulation contribute to a development of many disorders of the nervous system including multiple sclerosis, brain strokes, neurodegenerative disorders, brain tumors, schizophrenia, or Guillain-Barré syndrome. This article discusses a relationship between development of the nervous system diseases and the functional single nucleotide polymorphism (SNP) at position -1562C/T within the MMP-9 gene. A pathogenic influence of MMP-9-1562C/T SNP was observed both in neurological and psychiatric disorders. The presence of the allele T often increases the activity of the MMP-9 gene promoter and consequently the expression of MMP-9 when compared to the allele C. This leads to a change in the likelihood of an occurrence of diseases and modifies the course of certain brain diseases in humans, as discussed below. The presented data indicates that the MMP-9-1562C/T functional polymorphism influences the course of many neuropsychiatric disorders in humans suggesting a significant pathological role of the MMP-9 metalloproteinase in pathologies of the human central nervous system.

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Influence of Gelatinase B Polymorphic Variants and Its Serum Levels in Atherosclerosis

Cited by 9 publications

References 23 publications

Association of Genetic Polymorphisms in Matrix Metalloproteinase-9 and Coronary Artery Disease in the Chinese Han Population: A Case–Control Study

Association of Genetic Polymorphisms in Matrix Metalloproteinase-9 and Coronary Artery Disease in the Chinese Han Population: A Case–Control Study

Relationship of Gelatynase B Enzyme Activity and Coronary Artery Disease

Does the functional polymorphism-1562C/T of MMP-9 gene influence brain disorders?

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