Influence of garlic on serum cholesterol, serum triglycerides, serum total lipids and serum glucose in human subjects

Bakhsh, Rasool; Chughtai, M. I. D.

doi:10.1002/food.19840280213

Cited by 20 publications

(14 citation statements)

References 2 publications

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“…Studies on human subjects found that on a fatrich diet, the serum cholesterol, serum triglycerides and serum total lipids were signifi cantly increased as compared to normally fed diet for 2 weeks (Bakhsh and Chughtai 1984 ). When 40 g of garlic was substituted in fat-rich diet for 7 days, garlic signifi cantly reduced the serum cholesterol and serum triglycerides.…”

Section: Clinical Studiesmentioning

confidence: 98%

Allium sativum

Lim¹

2014

Edible Medicinal and Non Medicinal Plants

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Section: Clinical Studiesmentioning

confidence: 98%

Allium sativum

Lim¹

2014

Edible Medicinal and Non Medicinal Plants

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“…In recent years, garlic has been a focus of attention because of its potential role in the prevention of various aspects of cardiovascular disease [19, 20]. Evidence from numerous studies suggests that garlic works through various mechanisms to achieve this favorable effect including reduction of serum lipids and blood pressure levels, inhibition of platelet aggregation, and increasing fibrinolytic antioxidant activity.…”

Section: Garlic and Cardiovascular Disease Preventionmentioning

confidence: 99%

“…In the early 1980s, a trial done [19] on human subject after ingestion of 40 gm garlic demonstrated significant reduction in total cholestrol and triglyceride levels. Similarly, one study conducted by Mader [20] in 1990 among patients suffering from dyslipidemia over a period of 16 weeks using 800 mg of garlic (standardized to 1.3% of Alliin) showed 12% reduction in serum cholestrol levels and 17% reduction in triglyceride levels in comparison to placebo; however, it was also noticed that the greatest cholesterol-lowering effects were seen in patients with initial total cholesterol values between 250 and 300 mg/dL.…”

Section: Garlic Role In Dyslipidemiamentioning

confidence: 99%

Role of Garlic Usage in Cardiovascular Disease Prevention: An Evidence-Based Approach

Qidwai

Ashfaq

2013

Evidence-Based Complementary and Alternative Medicine

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Introduction. Rapidly growing prevalence of cardiovascular disease is a major threat for the developed as well as developing world warranting urgent need of intervention. Complementary and alternative medicines are gaining popularity among general population because of their safety profile and easy administration. Garlic, in particular, is considered to be one of the best disease-preventive foods because of its potent and widespread effects. This study was done to find out the role of garlic usage in cardiovascular disease prevention. Methodology. Major databases including Google, PubMed, MEDLINE, and Cochrane library view were used for the literature search. Clinical trials conducted on humans assessing role of garlic usage in cardiovascular disease prevention and the possible mechanisms responsible for such therapeutic actions were assessed. Results. Various clinical trials and meta-analyses conducted have shown positive impact of garlic in cardiovascular-disease prevention especially its effects on lipid levels; however, some contradictory results are also reported. Similarly, its effects on hypertension control, and platelet are also mild with limited data availability. The possible reason for these inconsistent results is the difference in preparations with diverse composition, variations in sulphur content present in different garlic preparations used, and methodological variations in subject recruitment, duration of study, dietary control and so forth. Conclusion. Garlic can be used as an adjuvant with lipid-lowering drugs for control of lipids, however, its role as a main therapeutic agent cannot be recommended and it is suggested that more meta-analyses using standardized preparations with a close watch on methodological shortfalls should be conducted to prove its role.

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“…These biological responses have been largely attributed to reduction of risk factors for cardiovascular diseases, cancer and stimulation of immune functions, enhanced detoxification of foreign compound, hepatoprotective, antimicrobial effect and antioxidant effect. 4 Garlic is reported to prevent cardiovascular disease by multiple effects, one of which is the decrease total cholesterol and triglycerides 5 , LDLc, VLDLc, while increase HDLc 6 and suppression of the cholesterol biosynthesis 7 . Studies prior to 1995 consistently concluded hypolipidemic action of garlic 8,9 .…”

mentioning

confidence: 99%

Untitled

2016

IJPSR

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ABSTRACT:The antidyslipidemic and antioxidant activities of Allium sativum (Garlic) and Aloe vera (Ghee-kuwar) extracts have been studied in two models of hyperlipidemia, triton and cholesterol rich high fat diet induced hyperlipidemia. A. sativum, A. vera and Gemfibrogil were macerated with 0.2% aqueous gum acacia and the suspension was fed orally to rats of group III, IV and V at a dose of 400mg, 1g/Kg, and 50 mg/Kg (b.w.p.o.) respectively with triton. Serum lipids were found to be lowered by Allium sativum and Aloe-vera in triton induced hyperlipidemia. On the other hand chronic feeding of these extracts to animals in cholesterol rich high fat diet induced hyperlipidemia for 30 days caused lowering in lipid and protein levels of β lipoproteins followed by an increase in α lipoproteins. The results of present study demonstrate that hypolipidemic activity of these extracts mediate through inhibition of hepatic lipid synthesis, increased faecal bile acid excretion and induced plasma LCAT activity in rats. Furthermore these extracts (100 and 200 µg/ml) inhibited the in vitro generation of superoxide anions and hydroxyl radicals in both enzymatic and non enzymatic systems.

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Influence of garlic on serum cholesterol, serum triglycerides, serum total lipids and serum glucose in human subjects

Cited by 20 publications

References 2 publications

Allium sativum

Allium sativum

Role of Garlic Usage in Cardiovascular Disease Prevention: An Evidence-Based Approach

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