Influence of functionalised multiwalled carbon nanotubes with imidazole derivative and thiosemicarbazide on MKN45 and SW742 cancer cells

Tahermansouri, Hasan; Abedi, Ehteram; Keshel, Saeed Heidari; Tarlani, Aliakbar

doi:10.1179/1753555714y.0000000251

Cited by 3 publications

(4 citation statements)

References 39 publications

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“…As seen in Fig. 4a, the MWCNT-amide sample exboxylic groups [17,18]. The two bonds at 2800-2970 cm -1 , which are seen in all spectra, are assigned to the CH stretching of MWCNT-COOH defects.…”

Section: Resultsmentioning

confidence: 86%

“…Apart from the carbon values, the atomic percentages of: H (2.06%) and N (2.22%) in MWCNT-amide (as compared to MWCNT-COOH) indicated that MWCNT-COOH is functionalized with 2-aminobenzamide. On the other hand, the decreasing of percentage of H from 2.06% to 1.84% for around 3200-3400, 3056, 1520-1600, 1400-1520, 1200-1400, and 1000-1200 cm -1 could corresponded to NH, CH aromatic ring, C=C, C=N, C-N, and C-O stretching modes, respectively [15][16][17][18]. Thus, the FT-IR spectra confirm that MWCNT-COOH has been successfully modified by 4-hydroxyquinozaline.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, a comparison of the D and G band intensity ratios (I D /I G ) of the three samples (Fig. 5) shows that the graphite structure of the MWCNTs is not changed by these reactions [11,18].…”

Section: Resultsmentioning

confidence: 99%

“…For example, Pastorin et al [9] have developed CNT-methotrexate conjugates via covalent linkage for the use of CNTs as multimodal drug delivery systems. Extensive research has been carried out on the functionalization of CNTs based on cycloaddition [10], carbanion addition [11], radical addition [12] and amidation [13][14][15][16][17][18]. In this current study, carboxylated multi-wall carbon condenser.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, characterization, and toxicity of multi-walled carbon nanotubes functionalized with 4-hydroxyquinazoline

Tahermansouri¹,

Mirosanloo²,

Keshel³

et al. 2016

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The attachment of 2-aminobenzamide to carboxylated multi-wall carbon nanotubes (MWCNTs)-COOH was achieved through the formation of amide bonds. Then, the functionalized MWCNTs, MWCNT-amide, were treated by phosphoryl chloride to produce MWCNT-quin. The products were characterized by Fourier transform infrared spectroscopy, Raman spectroscopy, scanning electron microscopy, thermogravimetric analysis, derivative thermogravimetric, steady-state fluorescence spectroscopy, and solubility testing. MWCNT-quin showed photo-electronic properties, which is due to the attachment of the 4-hydroxyquinazoline groups to them as proved by steady-state fluorescence spectroscopy. This suggests intramolecular interactions between the tubes and the attached 4-hydroxyquinazoline. The toxicity of the samples was evaluated in human embryonic kidney HEK293 and human breast cancer SKBR3 cell lines, and the viable cell numbers were measured by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyltetrazolium bromide (MTT) after the cells were cultured for 24 h. Cellular investigations showed that the modified MWCNTs, particularly MW-CNT-quin, have considerably significant toxic impact on SKBR3 as compared to HEK293 at the concentration of 5 µg/mL.

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Section: Resultsmentioning

confidence: 86%