Functionalisation of multiwalled carbon nanotubes with thiazole derivative and their influence on SKBR3 and HEK293 cell lines

Tahermansouri, Hasan; Islami, Fereshteh; Gardaneh, Mossa; Kiani, Farhoush

doi:10.1179/1753555715y.0000000062

Cited by 8 publications

(2 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…44 However, high concentrations of TiO 2 nanoparticles were shown to induce serious cytotoxicity in some normal cells. 44,45 Kim et al 45 showed that the IC 50 value of TiO 2 nanoparticles in a normal cell line (L-132) was markedly higher than that in A549 lung cancer cells, demonstrating dose-dependent nanocytotoxicity between normal and cancer cells. This was in accordance with our current results, which showed obvious toxicity of TiO 2 in liver cancer cells but not in L02 cells.…”

Section: Discussionmentioning

confidence: 99%

“…43 TiO 2 had a significant toxic effect in human breast cancer SKBR3 cells but not in human embryonic kidney HEK293 cells. 44 However, high concentrations of TiO 2 nanoparticles were shown to induce serious cytotoxicity in some normal cells. 44,45 Kim et al 45 showed that the IC 50 value of TiO 2 nanoparticles in a normal cell line (L-132) was markedly higher than that in A549 lung cancer cells, demonstrating dose-dependent nanocytotoxicity between normal and cancer cells.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Titanium dioxide nanoparticles induce endoplasmic reticulum stress-mediated apoptotic cell death in liver cancer cells

et al. 2020

J Int Med Res

View full text Add to dashboard Cite

Objective Titanium oxide (TiO2) acts as a photosensitizer in photodynamic therapy by mediating reactive oxygen species (ROS)-induced endoplasmic reticulum (ER) stress. This study aimed to investigate the effect of TiO2 on ER stress in liver cancer cells. Methods Normal human liver and human hepatocarcinoma cell lines were incubated with various concentrations of TiO2 nanotubes for 48 hours. Cell growth, apoptosis, cell cycle, and cellular ROS were detected. Expression levels of ER stress sensors (PERK and ATF6) and Bax were evaluated by western blot. The effect of TiO2 on liver cancer growth was also investigated in mice in vivo. Results TiO2 inhibited cell growth, increased apoptosis and cellular ROS levels, and arrested the cell cycle in G1 stage in liver cancer cells. TiO2 also increased PERK, ATF6, and Bax expression levels in liver cancer cells in dose-dependent manners. TiO2 had no significant effect on cell growth, apoptosis, ROS level, cell cycle distribution, or PERK, ATF6, or Bax expression in normal liver cells. TiO2 administration reduced tumor volume and increased PERK, Bax, and ATF6 expression levels in tumor tissues in vivo. Conclusions TiO2 nanoparticles increased ROS-induced ER stress and activated the PERK/ATF6/Bax axis in liver cancer cells in vitro and in vivo.

show abstract