Influence of folic acid supplementation on coagulation, inflammatory, lipid, and kidney function parameters in subjects with low and moderate content of folic acid in the diet

Mierzecki, Artur; Makarewicz‐Wujec, Magdalena; Kłoda, Karolina; Kozłowska−Wojciechowska, Małgorzata; Pieńkowski, Paweł; Naruszewicz, Marek

doi:10.5603/kp.a2014.0209

Cited by 12 publications

(13 citation statements)

References 29 publications

(28 reference statements)

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“…Hyperhomocysteinemia > 15 μmol/l is a risk factor for atherosclerosis and thromboembolic diseases. Folic acid administration during treatment with MTX reduces the concentration of homocysteine [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

The effect of subcutaneous methotrexate on markers of metabolic syndrome in psoriatic patients – preliminary report

Owczarczyk‐Saczonek

Drozdowski

Maciejewska-Radomska

et al. 2018

pdia

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IntroductionMethotrexate (MTX) has anti-proliferative and anti-inflammatory effects in psoriasis. Moreover, low doses can reduce the risk of developing cardiovascular diseases. It turns out that psoriasis and atherosclerosis have a similar pathogenetic mechanism: the same pro-inflammatory cytokines, Th1 and Th17, are involved in both diseases.AimTo evaluate the effects of metabolic markers, protective cytokines (interleukin 10 (IL-10), transforming growth factor β (TGF-β)) and a marker of endothelial damage (endocan) in patients with plaque psoriasis.Material and methodsThe study included 24 patients aged 27–69 years (9 female, 15 male) with plaque psoriasis. The metabolic syndrome according to the International Diabetes Federation (IDF) was evaluated. The laboratory tests were performed under fasting conditions: C-reactive protein (CRP), glucose, total cholesterol, triglycerides, high-density lipoprotein (HDL), uric acid, endocan, IL-10, and TGF-β. After 12 weeks of treatment with MTX injections 15 mg/week, every patient was assessed with the same laboratory tests.ResultsAfter treatment we observed a statistically significant increase of endocan and IL-10, but no significant differences in the titer of TGF-β. C-reactive protein was reduced by approximately 54.7%. No improvement of lipid profile was observed, and even a significant increase in triglycerides was noted. Similarly, no significant difference was seen in the case of glucose and uric acid prior to and after treatment.ConclusionsMethotrexate in low doses in short-term treatment decreases CRP (anti-inflammatory effect) and increases endocan and IL-10 (potential protective role). Methotrexate is characterized by good efficacy and tolerability in therapy of patients with psoriasis.

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Section: Introductionmentioning

confidence: 99%

The effect of subcutaneous methotrexate on markers of metabolic syndrome in psoriatic patients – preliminary report

Owczarczyk‐Saczonek

Drozdowski

Maciejewska-Radomska

et al. 2018

pdia

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“…Furthermore, a continuous measure of folate concentration has statistically more power to detect differences compared to the categorical approach of folic acid supplementation. A study among young adults suggested that folic acid supplementation in subjects with low dietary content of folic acid was associated with decreased creatinine concentrations and subsequently higher eGFR 29. Another study among 6 to 8 year old children in rural Nepal suggested that maternal folic acid supplementation reduced the risk of microalbuminuria 30.…”

Section: Discussionmentioning

confidence: 99%

“…A study among young adults suggested that folic acid supplementation in subjects with low dietary content of folic acid was associated with decreased creatinine concentrations and subsequently higher eGFR. 29 Another study among 6 to 8 year old children in rural Nepal suggested that maternal folic acid supplementation reduced the risk of microalbuminuria. 30 Folate is important for homocysteine metabolism.…”

Section: Discussionmentioning

confidence: 99%

Maternal and Fetal Folate, Vitamin B 12 , and Homocysteine Concentrations and Childhood Kidney Outcomes

Miliku

Mesu

Franco

et al. 2017

American Journal of Kidney Diseases

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BackgroundFolate, vitamin B12 and homocysteine concentrations during pregnancy are important factors for early development and may persistently influence kidney function in the offspring. We examined the associations of folate, vitamin B12, and homocysteine concentrations during pregnancy with kidney outcomes in school-aged children.Study designPopulation-based prospective cohort study from fetal life onwards.Settings & participantsThis study was performed among 4,226 pregnant women and their children.PredictorsFolate, vitamin B12 and homocysteine blood concentrations measured in early pregnancy (median gestational age 13.2 weeks (25th to 75th percentiles 12.2, 14.8) and at birth (cord blood).Outcomes & measurementsAt the median age of 6.0 years (25th to 75th percentiles 5.9, 6.3) we measured combined kidney volume with ultrasound, estimated glomerular filtration rate based on creatinine (eGFRcreat) and cystatin C (eGFRcystC) concentrations and microalbuminuria.ResultsWe observed that higher maternal folate concentrations were associated with larger childhood combined kidney volume, whereas higher maternal vitamin B12 concentrations were associated with higher childhood eGFRcystC (p-values <0.05). These associations were independent of homocysteine concentrations. Higher maternal homocysteine concentrations were associated with smaller combined kidney volume and lower childhood eGFRcystC (p-values <0.05). The association of maternal homocysteine concentrations with childhood eGFRcystC was largely explained by combined kidney volume. Higher cord blood homocysteine concentrations were associated with larger combined kidney volume and lower eGFRcystC (p-values <0.05). Folate, vitamin B12 or homocysteine concentrations were not associated microalbuminuria.LimitationsObservational study, so causality cannot be established.ConclusionOur findings suggest that folate, vitamin B12 and homocysteine concentrations during fetal life are associated with offspring kidney development. However, the effect sizes are small. Further studies are needed to replicate these findings and assess the causality and consequences for kidney health in later life.

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“…51 However, folic acid supplementation has not shown any influence on the coagulation, inflammatory and lipid parameters in patients with atherosclerosis risk factors. 52 The association between dietary folate and carotid plaque, specifically in SLE, remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Dietary micronutrient intake and atherosclerosis in systemic lupus erythematosus

Lourdudoss

Elkan

Hafström

et al. 2016

Lupus

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Influence of folic acid supplementation on coagulation, inflammatory, lipid, and kidney function parameters in subjects with low and moderate content of folic acid in the diet

Cited by 12 publications

References 29 publications

The effect of subcutaneous methotrexate on markers of metabolic syndrome in psoriatic patients – preliminary report

The effect of subcutaneous methotrexate on markers of metabolic syndrome in psoriatic patients – preliminary report

Maternal and Fetal Folate, Vitamin B 12 , and Homocysteine Concentrations and Childhood Kidney Outcomes

Dietary micronutrient intake and atherosclerosis in systemic lupus erythematosus

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