Dietary micronutrient intake and atherosclerosis in systemic lupus erythematosus

Lourdudoss, Cecilia; Elkan, Ann‐Charlotte; Hafström, Ingiäld; Jogestrand, Tomas; Gustafsson, Thomas; Vollenhoven, R. van; Frostegård, Johan

doi:10.1177/0961203316655211

Cited by 12 publications

(7 citation statements)

References 46 publications

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“…To this aim, biomarkers can be a superior method to determine Se nutritional status. 20 Our data show that jSLE patients had highly variable cumulative doses of corticosteroids; half of included patients were on corticosteroids upon enrollment. The excessive use of corticosteroids leads to an increase in gluconeogenesis and impairs insulin sensitivity, leading to abnormalities in carbohydrate metabolism.…”

Section: Discussionmentioning

confidence: 69%

Selenium nutritional status and its association with SLEDAI-2K, HOMA-IR and lipid profile in Juvenile Systemic Lupus Erythematosus patients

Prado

Aires

Souza

et al. 2022

Lupus

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Objectives To assess nutritional status regarding selenium in adolescents with Juvenile Systemic Lupus Erythematosus (jSLE) and analyze possible associations with disease activity, insulin resistance and lipid profile. Methods This was an observational, cross-sectional study of 31 female adolescents with jSLE and 31 healthy female volunteers as a comparison group. We obtained demographic, anthropometric (weight, stature, waist, and neck circumferences), and clinical data (disease activity measured by SLEDAI-2K) from both groups; laboratory data including: lipid profile, plasma selenium, erythrocyte glutathione peroxidase activity (GPx), plasma malondialdehyde (MDA), ultrasensitive C-reactive protein (usCRP), insulin levels, and glycemia (Homeostasis Model Assessment for Insulin Resistance—HOMA-IR). Results Mean age at diagnosis of jSLE group was 15.9±1.7 years, with mean disease duration of 3.6±2.6 years. 48% of patients and controls had below-reference Se levels (≤46mcg/L). GPx was more frequently below reference levels (<4.171U/L) in the jSLE group, compared to controls. A ROC curve was used to assess the power of the variables to discriminate between both groups; insulin (AUC = 0.712; CI 95% 0.584–0.840), waist-to-height ratio (AUC = 0.704; CI 95% 0.572–0.837), and HOMA-IR (AUC = 0.689; CI 95% 0.556–0.822) were the variables with the greatest discriminatory power. Linear regression showed an independent inverse association between Se levels and c-LDL; no such correlation was found for GPx activity. SLEDAI-2 K and HOMA-IR showed no association with levels of Se and GPx activity. Conclusions Approximately, 50% of jSLE adolescents had below reference Se levels. The frequency of inadequate GPx values was higher in patients, compared to controls. There was an independent inverse association between Se and c-LDL levels in both groups; this was not the case for HOMA-IR and SLEDAI-2K. The data show the importance of assessing Se nutritional status in jSLE patients.

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Section: Discussionmentioning

confidence: 69%

Selenium nutritional status and its association with SLEDAI-2K, HOMA-IR and lipid profile in Juvenile Systemic Lupus Erythematosus patients

Prado

Aires

Souza

et al. 2022

Lupus

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“…To date, there are no studies in the literature in the SLE population reporting similar results, possibly owing to the diversity of methodologies, although a study demonstrated that a dietary folic acid deficiency in SLE may be associated with atherosclerosis 19 , which in the present study was associated with MR. High micronutrient intake was reported as protective against excess weight in the Mexican SLE population 14 .…”

Section: Discussionmentioning

confidence: 54%

“…In another study, low fruit and vegetable consumption and insufficient dietary calcium and iron intake were observed 15 . The literature reports low micronutrient intake in patients with SLE and its possible association with atherosclerosis in this population 19 . The present study found an association of insufficient intake of some micronutrients with MR; i.e., an insufficient intake of folic acid (vitamin B9), choline, and sulfur was associated with the grouping of anthropometric indicators for obesity.…”

Section: Discussionmentioning

confidence: 80%

Nutritional aspects and cardiovascular risk in systemic lupus erythematosus

Calzza

Muza

Gasparin

et al. 2021

Rev. Assoc. Med. Bras.

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OBJECTIVE:Patients with systemic lupus erythematosus present with a higher number of classic risk factors for coronary diseases and a higher prevalence of metabolic syndrome resulting from the disease itself. To evaluate the nutritional indicators of the cardiovascular risk of patients with systemic lupus erythematosus by analyzing eating habits, anthropometry, laboratory data, and disease activity and to describe the prevalence of patients fulfilling the criteria for metabolic syndrome.METHODS: Anthropometric measurements including waist circumference, food recall, and laboratory tests. RESULTS:The population presented an insufficient daily intake of micronutrients. Anthropometry revealed that 37.5% of the patients were classified with degree II obesity by body mass index and 76.8% by abdominal obesity. Regarding metabolic syndrome, 18 patients (16%) fulfilled the diagnostic criteria.CONCLUSIONS: Individuals with systemic lupus erythematosus presented with increased risk factors, as determined using anthropometric measurements and laboratory tests, for cardiovascular disease, indicating the need for nutritional guidance in this population to reduce cardiovascular risk, increase the quality of life, and increase survival of these patients.

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“…With the inclusion of walnuts in the diets of our participants, the dietary intake of carbohydrate, sugar, fiber, potassium, sodium, riboflavin, niacin, vitamin B 6 , folic acid, vitamin B 12 , vitamin A, and cholesterol did not show any meaningful changes. According to previous studies, [34][35][36][37][38][39] increased dietary intake of potassium, fiber, riboflavin, niacin, vitamin B 6 , folic acid, vitamin B 12 , and vitamin A has been associated with reduced cardiometabolic risk factors. The increased dietary intake of carbohydrate, sugar, sodium, and cholesterol has been associated with increased cardiometabolic risk factors.…”

Section: Discussionmentioning

confidence: 99%

The Resulting Variation in Nutrient Intake With the Inclusion of Walnuts in the Diets of Adults at Risk for Type 2 Diabetes: A Randomized, Controlled, Crossover Trial

et al. 2018

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Dietary micronutrient intake and atherosclerosis in systemic lupus erythematosus

Cited by 12 publications

References 46 publications

Selenium nutritional status and its association with SLEDAI-2K, HOMA-IR and lipid profile in Juvenile Systemic Lupus Erythematosus patients

Selenium nutritional status and its association with SLEDAI-2K, HOMA-IR and lipid profile in Juvenile Systemic Lupus Erythematosus patients

Nutritional aspects and cardiovascular risk in systemic lupus erythematosus

The Resulting Variation in Nutrient Intake With the Inclusion of Walnuts in the Diets of Adults at Risk for Type 2 Diabetes: A Randomized, Controlled, Crossover Trial

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