Influence of fluorapatite minor additions on behavior of hydroxyapatite ceramics

Abstract

Fluorinated hydroxyapatite is known to be less soluble by body fluids, resulting in enhanced resistance to biodegradation in vivo conditions, as compared to the pure hydroxyapatite ceramics. The present work was aimed at the investigation of the effect of minor additions of ultrafine fluorapatite (up to 10 wt%) on the sintering behavior and mechanical properties of hydroxyapatite ceramics. In vitro testing for the osteoblast-like cells viability and proliferation was performed with the samples of varying fluorapatite content. It was found that the fluorapatite addition hinders the sintering shrinkage and lowers the strength, but does not generally affect negatively the viability of the cells.

The comprehensive in vitro evaluation of eight different calcium phosphates: Significant parameters for cell behavior

“…Fluorinated hydroxyapatite is generally considered to be a highly biocompatible material with beneficial effects on the adhesion, growth and osteogenic differentiation of osteoblasts, including osteoblast‐like MG‐63 cells . The addition of ultrafine fluorinated hydroxyapatite (up to 10 wt.%) to hydroxyapatite did not negatively affect the viability and proliferation of MG‐63 cells in cultures on these substrates . However, when the fluorinated compounds (ie, solvents for the preparation of polymeric scaffolds for bone tissue engineering purposes) were soluble, they were able to leach from the materials and penetrate into cells they behaved cytotoxically .…”

Calcium Orthophosphates in Nature, Biology and Medicine

“…Due to the lowest solubility, good chemical stability and toxicity of high amounts of fluorides, chemically pure FA is rarely used as a bone substituting material [323]. However, due to the ability to form FHA and/or HFA, minor amounts of fluorides might be intentionally added to calcium orthophosphate biomaterials [324,325,326,327,328,329,330]. The effect of fluoride contents in FHA on both osteoblast behavior [331] and leukemia cells proliferation [332] has been described.…”

Influence of fluorine substitution on the morphology and structure of hydroxyapatite nanocrystals prepared by hydrothermal method

“…Along with pristine HAp, HAp with the addition of other inorganic elements such as fluorine [4,5], strontium [6e8], europium [9], yttrium [10] etc., has been used for some specific application such as drug delivery [7,9] and light emitting [5] and luminescence applications [2,8]. Fluor-hydroxyapatite [FHAp; Ca 10 (PO 4 ) 6 (OH,F) 2 ] its fluoridated form, has gained its importance in the area of dental restoration because of its specific biological benefits including the resistance of apatite to resorption by body fluids [11]. Incorporation of fluorine is known to protect the teeth from caries formation [4].…”