Influence of Flaxseed on Some Biochemical Factors, Antioxidant Activity and Expression of ABCG5 and ABCG8 Genes in the Liver of Diabetic Rat

Mohammadi, Abbas; Mohammadi, Naser; Najafi, Nader; Hasanpoor, K; Taheri, Reihane; Oubari, Farhad; Oshaghi, Ebrahim Abbasi

doi:10.9734/bjmmr/2014/8509

Cited by 7 publications

(9 citation statements)

References 24 publications

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“…Protein glycation is involved in the progress of complications such as retinopathy, neuropathy, nephropathy, dermopathy, and atherosclerotic lesions [1, 33, 35–37]. In the chronic state, excess glucose binds to free amino groups in tissue or blood proteins and body fluid and disturbs their functions [38–40].…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, chemical drugs generally have low efficacy over time, are too expensive, and show severe side effects such that some patients cannot tolerate prolonged treatment or taking the high dosages of these drugs. In contrast, herbal medicines are regarded as potential sources for medication due to their useful effects, negligible side effects in clinical trials, and low cost [53–59]. …”

Section: Resultsmentioning

confidence: 99%

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The Role ofAnethum graveolensL. (Dill) in the Management of Diabetes

Goodarzi

Khodadadi

Tavilani

et al. 2016

Journal of Tropical Medicine

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Aim. There is evidence that Anethum graveolens (AG) has been used for centuries in Asian traditional medicine, and its constituents have useful effects on the control and management of diabetes and cardiovascular disorders. AG has many useful effects, including hypolipidemic and hypoglycemic effects, and it has been reported to reduce the incidence of diabetic complications. It acts mainly by affecting antioxidant capacity and change in some genes in glucose and lipid pathways. The aim of the present paper was to summarize pharmacological effects of AG in the management of diabetes. Methods. To prepare this review, a pharmacological and phytochemical literature survey was performed using Scopus, PubMed, and Web of Science. Also, some historical and ethnopharmacological literature sources were used. Results. This review plans to provide readers with an assessment of the pharmacological effects of AG, especially in diabetes. Conclusion. The paper highlights the therapeutic effects of AG which would aid in supporting their safe use in the management of diabetes and cardiovascular diseases.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

The Role ofAnethum graveolensL. (Dill) in the Management of Diabetes

Goodarzi

Khodadadi

Tavilani

et al. 2016

Journal of Tropical Medicine

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“…Liver enzymes, total cholesterol, fasting blood sugar, triglyceride, and HDL-C were measured by colorimetric methods using the commercial available kits (Pars Azmun, Tehran, Iran), whereas LDL-C and VLDL-C were calculated by Friedwald's formula [8, 9]. …”

Section: Methodsmentioning

confidence: 99%

Lipid Lowering Effects of Hydroalcoholic Extract of Anethum graveolens L. and Dill Tablet in High Cholesterol Fed Hamsters

et al. 2015

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Objective. This study was aimed to determine the effect of Anethum graveolens extract and Anethum graveolens (dill) tablet on lipid profile, liver enzymes, and gene expression and enzymatic activity of HMG-CoA reductase in high cholesterol fed hamsters. Materials and Methods. Golden Syrian male hamsters (130 ± 10 g) were randomly divided into 6 groups (n = 6) and received daily the following: group 1 received chow + 2% cholesterol + 0.5% cholic acid (HCD), groups 2 and 3 received HCD diet plus 100 and 200 mg/kg hydroalcoholic extract of dill, respectively, and groups 4 and 5 received HCD diet plus 100 and 200 mg/kg dill tablet, respectively. Group 6 received only chow. After 1 month feeding serum biochemical factors were determined. HMG-CoA reductase mRNA level was measured (real-time PCR) and its activity was determined spectrophotometrically. Results. Compared with hypercholesterolemic group 1, lipid profile, blood glucose, and liver enzymes significantly decreased in all dill tablet or dill extract treated groups (p < 0.05). The changes in HMG-CoA reductase gene expression level and enzyme activity significantly reduced in animals that received 200 mg/kg of extract or tablet. Conclusion. Dill extract and dill tablet showed potential hypocholesterolemic properties in hamsters by inhibition of HMG-CoA reductase activity.

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“…Kidneys of the animals were removed and some parts were used for histopathological examination and the other parts for determination of oxidative stress markers. The malondialdehyde (MDA) level, as an indicator of lipid peroxidation, was determined using the thiobarbituric acid method (21). The results were stated as nmol of MDA/ gram protein.…”

Section: Determination Of Oxidative Stress and Biochemical Markersmentioning

confidence: 99%

“…Hyperglycemia and oxidative stress are known as main factors in diabetic complications (2). In this respect, natural products which are capable of reducing blood glucose and scavenging of free radicals play major role in treatment of diabetes (3)(4)(5)(6).…”

Section: Introductionmentioning

confidence: 99%

Renoprotective Effects of Trigonella foenum and Cinnamon on Type 2 Diabetic Rats

Kassaee

Goodarzi

Oshaghi

2017

Avicenna J Med Biochem

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Background: Herbal medicine is used in all parts of the world mainly for prevention and treatment of various disorders due to better cultural suitability, lower cost and less side effects. Objectives: The aim of this study was to determine the hypoglycemic and kidney-protective effects of the aqueous extract of Trigonella foenum and Cinnamon on diabetic rats. Methods: In this experimental study, rats were randomly divided into 6 groups as follows: Group 1: control group in which animals received chow diet, group 2: diabetic rats, group 3: diabetic rat + 2% T. foenum extract (w/w), group 4: diabetic rat + 8% of Trigonella foenum extract (w/w), group 5: diabetic rat + 2% Cinnamon extract (w/w) and group 6: diabetic rat + 8% of Cinnamon extract (w/w). Aqueous extract of T. foenum leaves and Cinnamon were administered to diabetic rats for 4 weeks. The malondialdehyde (MDA) level and total antioxidant capacity were also measured in kidney of the animals. In addition, morphological changes of the kidney were also analyzed by the light microscope. Results: Trigonella foenum and Cinnamon extract in diabetic animals significantly reduced MDA levels and restored antioxidant capacity (P<.05). T. foenum and Cinnamon also normalized plasma urea and creatinine concentration in diabetic rats (P<.05). Administration of T. foenum and Cinnamon extract especially at the dose of 8 mg/kg normalized histopatholgical changes of kidney in diabetic animal. Conclusions: The findings of this experiment showed that T. foenum extract and Cinnamon restored antioxidant capacity and structural changes of kidney.

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Influence of Flaxseed on Some Biochemical Factors, Antioxidant Activity and Expression of ABCG5 and ABCG8 Genes in the Liver of Diabetic Rat

Cited by 7 publications

References 24 publications

The Role ofAnethum graveolensL. (Dill) in the Management of Diabetes

The Role ofAnethum graveolensL. (Dill) in the Management of Diabetes

Lipid Lowering Effects of Hydroalcoholic Extract of Anethum graveolens L. and Dill Tablet in High Cholesterol Fed Hamsters

Renoprotective Effects of Trigonella foenum and Cinnamon on Type 2 Diabetic Rats

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