Influence of flavonoids on mechanism of modulation of insulin secretion

Abstract

Background:The development of alternatives for insulin secretion control in vivo or in vitro represents an important aspect to be investigated. In this direction, natural products have been progressively explored with this aim. In particular, flavonoids are potential candidates to act as insulin secretagogue.Objective:To study the influence of flavonoid on overall modulation mechanisms of insulin secretion.Methods:The research was conducted in the following databases and platforms: PubMed, Scopus, ISI Web of Knowledge, SciELO, LILACS, and ScienceDirect, and the MeSH terms used for the search were flavonoids, flavones, islets of Langerhans, and insulin-secreting cells.Results:Twelve articles were included and represent the basis of discussion on mechanisms of insulin secretion of flavonoids. Papers in ISI Web of Knowledge were in number of 1, Scopus 44, PubMed 264, ScienceDirect 511, and no papers from LILACS and SciELO databases.Conclusion:According to the literature, the majority of flavonoid subclasses can modulate insulin secretion through several pathways, in an indication that corresponding molecule is a potential candidate for active materials to be applied in the treatment of diabetes.SUMMARY The action of natural products on insulin secretion represents an important investigation topic due to their importance in the diabetes controlIn addition to their typical antioxidant properties, flavonoids contribute to the insulin secretionThe modulation of insulin secretion is induced by flavonoids according to different mechanisms. Abbreviations used: KATP channels: ATP-sensitive K+ channels, GLUT4: Glucose transporter 4, ERK1/2: Extracellular signal-regulated protein kinases 1 and 2, L-VDCCs: L-type voltage-dependent Ca+2 channels, GLUT1: Glucose transporter 1, AMPK: Adenosine monophosphate-activated protein kinase, PTP1B: Protein tyrosine phosphatase 1B, GLUT2: Glucose transporter 2, cAMP: Cyclic adenosine monophosphate, PKA: Protein kinase A, PTK: Protein tyrosine kinase, CaMK II: Ca2+/calmodulin-dependent protein kinase II, GSIS: Glucose-stimulated insulin secretion, Insig-1: Insulin-induced gene 1, IRS-2: Insulin receptor substrate 2, PDX-1: Pancreatic and duodenal homeobox 1, SREBP-1c: Sterol regulatory element binding protein-1c, DMC: Dihydroxy-6’-methoxy-3’,5’-dimethylchalcone, GLP-1: Glucagon-like peptide-1, GLP-1R: Glucagon-like peptide 1 receptor.

Cyclohexane extract of walnut leaves improves indices of oxidative stress, total homocysteine and lipids profiles in streptozotocin‐induced diabetic rats

“…It can be proposed that quercetin and kaempferol content of walnut leaf extract, act as an antioxidant and scavenger of free radicals, and have a role in beta cell regeneration and protects pancreatic islets. Their possible mechanisms can be associated with anti-diabetic effect, antioxidant effect (Alkhalidy et al, 2015;Kawser Hossain et al, 2016), impact on hepatic glucokinase (Vessal et al, 2003), inhibition of gastrointestinal absorption of glucose (Kwon et al, 2007), glucosuric effect (Beekmann et al, 2015), and/ or insulin-like external pancreatic mechanisms (Alkhalidy et al, 2015;Soares, Pereira Leal, Silva, Almeida, & Oliveira, 2017). In our study, concentrations of lipid profiles including TC, TG, and LDL-c were significantly higher in diabetic rats compared to the control group.…”

Constituents of Coreopsis lanceolata Flower and Their Dipeptidyl Peptidase IV Inhibitory Effects

“…Compounds 2 – 5 have the chalcone skeleton, which is an α-β-unsaturated ketone with two phenyl rings. There have been several reviews on the biological and pharmacological activities of chancones, including anti-cancer, anti-malarial, anti-microbial, anti-inflammatory, anti-protozoal and anti-HIV activities [ 33 ], as well as its role in diabetes control [ 15 , 34 , 35 ]. In a comprehensive study into modulating the therapeutic targets PPAR-γ, DPP-IV, α-glucosidase, PTP1B, ALR and insulin secretion via anti-diabetic chalcones and their structure–activity relationships [ 15 ], in particular, it was reported that the chalcone structure of which the carbonyl group was replaced with an oxime function exhibited enhanced DPP-IV inhibitory activity.…”

“…In a comprehensive study into modulating the therapeutic targets PPAR-γ, DPP-IV, α-glucosidase, PTP1B, ALR and insulin secretion via anti-diabetic chalcones and their structure–activity relationships [ 15 ], in particular, it was reported that the chalcone structure of which the carbonyl group was replaced with an oxime function exhibited enhanced DPP-IV inhibitory activity. In addition, there have been reports that nitrochalcones and prenylated chalcones increase insulin secretion and glucose uptake, respectively [ 34 ]. Among chalcones isolated in this study, 3 – 5 showed less inhibitory activity than 2 , indicating that chalcones substituted with additional methoxy group and/or sugar are less effective.…”

Ethanolic extract of black grapes (Vitis Vinifera) ameliorates overtraining-induced pancreatic β-cells and muscle damage

“…Furthermore, previous studies reported that besides protecting pancreatic βcells from damage by oxidative stress, it also triggers the proliferation of β-cells within pancreatic islet (Pinent et al, 2008). Flavonoids play a role in controlling blood glucose by increasing insulin secretion through elevating metabolism of Ca 2+ and regenerate pancreatic β-cells (Dias Soares, Pereira Leal, Silva, Almeida, & de Oliveira, 2017;Ghorbani, Rashidi, & Shafiee-Nick, 2019). Through interaction with the ATP-sensitive K channels in the membrane of beta cells causing membrane depolarization and this situation will open Sodium gate channels.…”