Influence of flavonoids on long-term bonding stability on caries-affected dentin

Dávila-Sánchez, Andrés; Gutiérrez, Mário Felipe; Bermudez, J.; Méndez-Bauer, Luján; Hilgemberg, Bruna; Sauro, Salvatore; Loguércio, Alessandro Dourado; Arrais, César Augusto Galvão

doi:10.1016/j.dental.2020.05.007

Cited by 20 publications

(23 citation statements)

References 42 publications

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“…They are a large family of over 5000 hydroxylated polyphenolic compounds that perform important functions in plants, including combating environmental stresses, such as microbial infection, and regulating cell growth [13]. Several flavonoids were used to improve dentin bonding stability [12,[14][15][16]. Hesperidin, a flavonoid extracted from citrus fruits, improves the mechanical properties of resin-dentin interfaces, and increases the immediate bonding strength of a self-etching adhesive [12].…”

Section: Introductionmentioning

confidence: 99%

“…Hesperidin, a flavonoid extracted from citrus fruits, improves the mechanical properties of resin-dentin interfaces, and increases the immediate bonding strength of a self-etching adhesive [12]. Quercetin, rutin, and naringin were proven to be effective for improving the long-term stability of dentin bonding [16]. However, there is a lack of studies on the effects of various types of flavonoids in dentin bonding.…”

Section: Introductionmentioning

confidence: 99%

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Dentin Biomodification with Flavonoids and Calcium Phosphate Ion Clusters to Improve Dentin Bonding Stability

et al. 2022

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The purpose of this study was to evaluate the effects of flavonoids and calcium phosphate ion clusters (CPIC) on dentin bonding stability. Seven experimental solutions were synthesized using icaritin (ICT), fisetin (FIS), silibinin (SIB), CPIC, and combinations of one of three flavonoids and CPIC (ICT + C, FIS + C, SIB + C). The experimental solutions were applied to demineralized dentin prior to the application of a universal adhesive. A group without any experimental solution served as a control. Dentin specimens pretreated with the experimental solutions were assayed using Fourier transform infrared (FTIR) spectroscopy. The microtensile bond strength (µTBS) and nanoleakage were evaluated at 24 h and after 10,000 thermocycles. FIS and ICT + C showed significantly higher µTBS than the control group at 24 h. CPIC, ICT + C, FIS + C, and SIB + C showed significantly higher µTBS than the control group after thermocycling. After thermocycling, silver infiltration into the hybrid layer and interfacial gaps was more noticeable in the control group than in the other groups. The FTIR spectra revealed the formation of apatitic minerals in the demineralized dentin in the flavonoid and CPIC combination groups. The pretreatment of demineralized dentin with flavonoids and CPIC improved dentin bonding stability. The flavonoid and CPIC combinations preserved dentin bond strength.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dentin Biomodification with Flavonoids and Calcium Phosphate Ion Clusters to Improve Dentin Bonding Stability

et al. 2022

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“…Modern restorative dentistry is mainly focused on preserving tooth structure during cavity preparation and applying nonaggressive methods in treating carious lesions [1]. Carious dentin is composed of two discrete layers: (1) the caries-infected layer which contains irreversible denatured collagen fibrils and is physiologically unremineralizable and (2) the caries-affected dentin (CAD) which is uninfected, partially demineralized, and physiologically remineralizable [2,3]. Hence, selective caries removal techniques discard the caries-infected layer and maintain the CAD due to its remineralization ability [1,4,5].…”

Section: Introductionmentioning

confidence: 99%

Microshear Bond Strength of Nanoparticle-Incorporated Conventional and Resin-Modified Glass Ionomer to Caries-Affected Dentin

Fattah

Jowkar

Rezaeian

2021

International Journal of Dentistry

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The purpose of this study was to assess the influence of three different types of nanoparticles (silver (SNPs), titanium dioxide (TNPs), and zinc oxide (ZNPs)) on the microshear bond strength of conventional glass ionomer cement (CGIC) and resin-modified glass ionomer cement based on whether CGIC or RMGIC is used with four subgroups (based on the incorporation of SNPs, ZNPs, and TNPs in addition to a control subgroup) (n = 12) as follows: CGIC, CGIC + TNP, CGIC + ZNP, CGIC + SNP, RMGIC, RMGIC + TNP, RMGIC + ZNP, and RMGIC + SNP. After 24 hours, the μSBS of specimens was tested and the obtained data were analyzed using two-way ANOVA and Tukey’s HSD test. The obtained results showed that the incorporation of TNPs in two glass ionomers was not statistically significant compared with the control subgroups ( p > 0.05). In the first group, the highest and lowest mean μSBS were, respectively, observed in the CGIC + SNP subgroup and CGIC + ZNP subgroup. In the second group, RMGIC + ZNP and RMGIC + SNP, respectively, showed the highest and lowest mean μSBS compared to the other subgroups. According to the results, it can be concluded that TNPs can be incorporated into both CGIC and RMGIC without compromising the bond strength of glass ionomers. SNPs and ZNPs can be, respectively, added to CGICs and RMGICs to improve the bond strength of the restoration.

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“…Collagen cross-linkers have also been used to enhance the mechanical properties of the demineralized collagen network as well as bond durability in coronal [11,[30][31][32][33] and radicular dentin [34]. Because cross-linking of the collagen matrix is a naturally-occurring phenomenon in dentin, scientists have resorted to the use of chemical substances with cross-linking properties to render the dentin collagen matrix less susceptible to proteolytic attack [4,35]. Among the cross-linking reagents, 1-ethyl-3-(3dimethylaminopropyl)carbodiimide (EDC), has demonstrated promising results in the preservation of the integrity of hybrid layers over time.…”

Section: Introductionmentioning

confidence: 99%

“…Among the cross-linking reagents, 1-ethyl-3-(3dimethylaminopropyl)carbodiimide (EDC), has demonstrated promising results in the preservation of the integrity of hybrid layers over time. This feature was attributed to the ability of EDC to cross-link peptides without introducing additional linkage groups [11,32,36]. N,N'-dicyclohexylcarbodiimide (DCC) is a crosslinker belonging to the same family as EDC, but with a different solubility behavior.…”

Section: Introductionmentioning

confidence: 99%

Effect of an ethanol cross-linker on universal adhesive

et al. 2020

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Objective. To evaluate the effects of N,N'-dicyclohexylcarbodiimide (DCC), an ethanol-based dentin cross-linker, on the immediate and long-term microtensile bond strength (TBS) and nanoleakage expression of a universal adhesive employed in self-etch mode (SE) or etchand-rinse mode (ER). The effect of DCC on the dentinal MMP activity was also investigated by means of in-situ zymography.Methods. Eighty freshly extracted human molars were sectioned to expose mid-coronal dentin surfaces. The teeth were assigned to one of the following groups, according to the dentin surface priming/adhesive approach: (G1): DCC pre-treatment and Scotchbond Universal (SBU) in ER mode; (G2): SBU in ER mode; (G3): DCC pretreatment and SBU in SE mode;(G4): SBU in SE mode. TBS test was performed immediately (T 0 ) or after 1-year aging (T 12 ) in artificial saliva. Ten additional teeth per group were prepared for nanoleakage evaluation (N = 5) and for in-situ zymography (N = 5).Results. Three-factor analysis of variance revealed significant difference for the variables DCC pretreatment, application mode and aging (p < 0.05) for both microtensile bond strength testing and in-situ zymography. Nanoleakage analysis revealed reduced marginal infiltration of DCC experimental groups both at T 0 and T 12 .

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Influence of flavonoids on long-term bonding stability on caries-affected dentin

Cited by 20 publications

References 42 publications

Dentin Biomodification with Flavonoids and Calcium Phosphate Ion Clusters to Improve Dentin Bonding Stability

Dentin Biomodification with Flavonoids and Calcium Phosphate Ion Clusters to Improve Dentin Bonding Stability

Microshear Bond Strength of Nanoparticle-Incorporated Conventional and Resin-Modified Glass Ionomer to Caries-Affected Dentin

Effect of an ethanol cross-linker on universal adhesive

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