A review is presented of the materials used to control or eliminate foam in industrial processes and how these materials function. These materials are classified by their chemical type. The main active liquid‐phase components are hydrocarbon oils, polyethers, and silicone fluids; the main solid‐phase components are waxy hydrocarbons and hydrophobic silica. Formulating the antifoam active into a suitable delivery system is essential to ensure optimal performance in terms of activity, physical and chemical stability, cost, ease of use and for preventing negative side, and downstream effects. Examples of formulations for antifoams delivery in dispersions, emulsions, or powders are described. The mechanisms of foaming and defoaming are outlined with an emphasis on surface behavior such as entering, spreading, bridging, stretching, and dewetting phenomena. The importance of entry barrier on the rapidity of antifoaming action, the role of dispersed hydrophobic solids, and the mechanism of antifoam deactivation are highlighted. Applications in various areas are briefly reviewed, including pulp and paper, fermentation, paints, coatings and inks, oil and petrochemicals, cleaning compounds, wastewater treatment, metal working, polymerization, construction, textiles, fertilizers, food and beverages, leather, adhesives and sealants, chemical processing, and, medical and pharmaceuticals. Economic and health and safety factors are considered. Test methods, such as pneumatic, dynamic, shaking, pouring, stirring, and blending methods, are also briefly reviewed.