Influence of extra- and intra-oral application of CPP-ACP and fluoride on re-hardening of eroded enamel

Wegehaupt, Florian J; Tauböck, Tobias T.; Stillhard, Angela; Schmidlin, Patrick R.; Attin, Thomas

doi:10.3109/00016357.2011.600713

Cited by 53 publications

(62 citation statements)

References 40 publications

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“…While microscopical analyses suggested that CPP-ACP forms aggregates and/or precipitates on the tooth surface 7,8 reducing further enamel erosion, 9 other studies did not show a preventive 10,11 or remineralizing effect. 12,13 The erosion-preventive effect of CPP-ACP was mostly observed when immersion periods of several hours were used.…”

Section: Introductionmentioning

confidence: 99%

Randomised in situ trial on the effect of milk and CPP-ACP on dental erosion

Wiegand

Attin

2014

Journal of Dentistry

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OBJECTIVES This randomised in situ study aimed to analyse the effect of milk (with or without 5ppm F) and CPP-ACP pastes (with or without 900ppm F) on dental erosion. METHODS The study was a seven phase (5 days each) crossover design involving 15 participants wearing intraoral appliances with enamel and dentine specimens. Specimens were extraorally eroded (erosive soft drink, 6×90s/day) and brushed (2×30s/day, 2N) using a non-fluoridated toothpaste (negative control). The test products were milk, milk+5ppm F (twice daily, each 100ml/2min), CPP-ACP paste, CPP-ACP paste+900ppm F (3min/day) or a SnCl2/AmF/NaF mouthrinse (positive control, 30s/day), which were applied immediately after erosion with the appliances in the oral cavity. In an additional group, a fluoridated toothpaste was used without any additional test product. Tissue loss was determined profilometrically after 5 days and statistically analysed by linear mixed models methodologies (p<0.05). RESULTS Compared with the negative control (non-fluoridated toothpaste only, enamel: 2.2±1.3m; dentine: 3.8±2.2m), enamel and dentine loss was significantly reduced by the use of fluoridated toothpaste (enamel: 1.1±1.0m; dentine: 2.4±1.7m) and the SnCl2/AmF/NaF mouthrinse (1.5±1.5m; dentine: 1.8±1.9m). CON-CLUSIONS Milk and CPP-ACP were not effective in reducing enamel and dentine loss significantly, independently of the presence of fluoride. CLINICAL SIGNIFICANCE Enamel and dentine erosion were significantly reduced by the use of a fluoridated toothpaste or a SnCl2/AmF/NaF mouthrinse, but not by milk or CPP-ACP under the conditions of the present study. CLINICAL TRIALS REGISTRATION NCT01566357. Randomized in situ trial on the effect of milk and CPP-ACP on dental erosion AbstractObjectives: This randomized in situ study aimed to analyse the effect of milk (with or without 5 ppm F) and CPP-ACP pastes (with or without 900 ppm F) on dental erosion.Methods: The study was a seven phase (5 days each) crossover design involving 15 participants wearing intraoral appliances with enamel and dentin specimens. Specimens were extraorally eroded (erosive soft drink, 6 x 90s/day) and brushed (2 x 30 s/day, 2 N) using a non-fluoridated toothpaste (negative control). The test products were milk, milk + 5 ppm F (twice daily, each 100 ml/2 min), CPP-ACP paste, CPP-ACP paste + 900 ppm F (3 min/day) or a SnCl 2 /AmF/NaF mouthrinse (positive control, 30 s/day), which were applied immediately after erosion with the appliances in the oral cavity. In an additional group, a fluoridated toothpaste was used without any additional test product. Tissue loss was determined profilometrically after 5 days and statistically analysed by linear mixed models methodologies (p < 0.05).Results: Compared with the negative control (non-fluoridated toothpaste only, enamel:2.2±1.3 µm; dentin: 3.8±2.2 µm), enamel and dentin loss was significantly reduced by the use of fluoridated toothpaste (enamel: 1.1±1.0 µm; dentin: 2.4±1.7 µm) and the SnCl 2 /AmF/NaF mouthrinse (1.5±1.5 µm; dentin: 1.8±1.9 µm)....

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Section: Introductionmentioning

confidence: 99%

Randomised in situ trial on the effect of milk and CPP-ACP on dental erosion

Wiegand

Attin

2014

Journal of Dentistry

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“…The use of topically applied fluoride compounds, such as sodium fluoride [5,6], amine fluoride [7], monofluorophosphate [5] or titanium tetrafluoride [7], results in a strengthening of the chemical resistance of dental hard tissues [2] or rehardening of erosivly softened enamel or dentine [8]. In the recent years, studies testing new products or active ingredients, namely stannous chloride [9], cerium chloride [10] or CPP-ACP containing pastes [11], intended to prevent erosion associated dental hard tissue loss or softening, have been published.…”

Section: Introductionmentioning

confidence: 99%

Durability of the anti-erosive effect of surfaces sealants under erosive abrasive conditions

Wegehaupt

Tauböck

Attin

2013

Acta Odontologica Scandinavica

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OBJECTIVE: To test the durability of sealants applied for prevention of erosive dentine mineral loss under erosive/abrasive conditions. METHODS: Forty-eight bovine dentine samples doped with (32)P were randomly allocated to four groups (1-4). All samples performed a de-and remineralizations precycling (6 × 1 min erosion in HCl: pH 3.0, mean time and overnight immersion in artificial saliva) for 1 day. Sealing was done as follows; (1) unsealed, (2) Seal Protect, (3) K-0184 (experimental sealer) and (4) OptiBond FL. After sealing, samples were immersed in HCl for 3 h (baseline measurement). Then, the following erosive/abrasive and remineralisations cycling was performed for 8 days: 3 h/day erosion with HCl, 600 brushing strokes/day and storage in artificial saliva for the rest of the day. Sealer permeability was evaluated by assignation of (32)P in the acid used for the erosive attacks. RESULTS: At baseline, the significantly highest dentine loss was observed for the unsealed control group, while the mineral loss was not statistically significantly different between the sealed groups 2 and 3. At all days of the erosive/abrasive and remineralizations cycling and cumulatively the significantly highest mineral loss was observed for group 1, while the significantly lowest mineral loss was observed for the samples sealed with Seal Protect (group 2) and K-0184 (group 3). In all groups, no significant increase in the (32)P release was observed. CONCLUSION: Surface sealants are able to reduce the erosive dentine mineral loss and maintain this erosion-preventing efficacy over the whole duration (simulating 8 month in-vivo) of the erosive/abrasive cycling. Abstract:Objective: To test the durability of sealants applied for prevention of erosive dentine mineral loss under erosive/abrasive conditions.Methods: 48 bovine dentine samples doped with 32 P were randomly allocated to four groups(1-4). All samples performed a de-and remineralisations precycling (6 x 1 min erosion in HCl: pH 3.0, mean time and over night immersion in artificial saliva) for one day. Sealing was done as follows; 1: unsealed, 2: Seal&Protect, 3: K-0184 (experimental sealer) and 4:OptiBond FL. After sealing, samples were immersed in HCl for 3 h (baseline measurement).Then, the following erosive/abrasive and remineralisations cycling was performed for 8 days:3 h/day erosion with HCl, 600 brushing strokes/day and storage in artificial saliva for the rest of the day. Sealer permeability was evaluated by assignation of 32 P in the acid used for the erosive attacks.Results: At baseline, the significantly highest dentine loss was observed for the unsealed control group, while the mineral loss was not statistically significantly different between the sealed groups 2-3.At all days of the erosive/abrasive and remineralisations cycling, and cumulative the significantly highest mineral loss was observed for group 1, while the significantly lowest mineral loss was observed for the samples sealed with Seal&Protect (group 2) and K-0184 (group 3). In all group...

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“…Os fosfopeptídeos de caseína (CPP) contêm a sequência de peptídeos -Ser (P) -Ser (P) -Ser (P) -Glu -Glu -que possuem capacidade para estabilizar fosfato de cálcio amorfo (ACP) em solução metaestável sobressaturada 13,34,35 . Assim sendo, o CPP-ACP atua como uma fonte suplementar de cálcio e fosfato biodisponíveis no ambiente bucal 17 , sendo proposto tanto por inibir a perda de minerais 3,5 , como para intensificar sua deposição em lesões desmineralizadas do esmalte dentário, à exemplo das lesões erosivas 30 19,25,27,[43][44][45][46] . No que diz respeito aos seus mecanismos de controle da erosão dentária, o CPP-ACP pode atuar tanto na precipitação mineral 17,39 , como na redução da desmineralização da estrutura dentária 36,39 .…”

Section: Resultados O Erosãounclassified

Utilização de pastas contendo fosfopeptídeo de caseína-fosfato de cálcio amorfo com e sem fluoreto na prevenção da erosão dentária: uma revisão da literatura

Fernandes¹,

Moura²,

Alencar³

et al. 2017

Arch Health Invest

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ResumoIntrodução: A erosão dentária caracteriza-se como uma perda progressiva de estrutura dentária em que ocorre dissolução localizada de minerais da superfície do dente, ocasionada devido a exposição a ácidos de origem não bacteriana. Esse agravo bucal tem ganhado destaque pelo aumento de sua prevalência, que tem ocorrido, principalmente, devido a mudança dos hábitos alimentares e no estilo de vida da sociedade moderna. Objetivo: Apresentar uma síntese da ação das pastas de CPP-ACP no controle da erosão dentária. Material e Método: Foi realizada uma revisão da literatura nas bases de dados eletrônicas: Pubmed, Scopus e Bireme, utilizando os termos Erosão Dentária, Tooth Erosion, Esmalte Dentário, Dental Enamel, Caseínas, Caseins, Fluoreto de Sódio, Sodium Fluoride e os operadores boleanos "AND" e "OR" para realização das buscas, não havendo restrição quanto ao ano ou idioma de publicação. Resultados: Diferentes condutas terapêuticas têm sido avaliadas como potenciais alternativas para o controle da erosão dentária, dentre os quais está o uso da caseína fosfopeptídeo -fosfato de cálcio amorfo (CPP-ACP). As pastas de CPP-ACP parecem ser o tipo de veículo com maior potencial preventivo, além disso, a literatura sugere também, que as abordagens adotadas previamente às exposições ácidas tendem a ser mais bem-sucedidas. Apesar disso, ainda não há um consenso sobre a eficácia desse recurso terapêutico, devido, principalmente a carência de estudos realizados sob protocolos in situ. Conclusão: A ação preventiva das pastas de CPP-ACP, suplementadas ou não pelo fluoreto, permanece incipiente na literatura. Descritores: Erosão Dentária; Esmalte Dentário; Caseínas; Fluoreto de Sódio. AbstractIntroduction: Dental erosion is characterized as a progressive loss of tooth structure in which localized dissolution of minerals from the tooth surface occurs due to exposure to acids of non-bacterial origin. This oral grievance has been highlighted by the increase in its prevalence, which has mainly occurred due to changes in eating habits and in the lifestyle of modern society. Objective: To present a synthesis of the action of CPP-ACP pulps in the control of dental erosion. Material and Methods: A literature review was carried out in the electronic databases: Pubmed, Scopus e Bireme, using the terms Erosion, Tooth Erosion, Dental Enamel, Dental Enamel, Caseins, Caseins, Sodium Fluoride, Sodium Fluoride and the Boolean operators "AND" and "OR" to carry out the searches, without restriction regarding the year or language of publication. Results: Different therapeutic approaches were evaluated as possible alternatives for the control of dental erosion, among them the use of phosphine casein -amorphous calcium phosphate (CPP-ACP). CPP-ACP pulps seem to be the type of vehicle with the greatest preventive potential, and the literature also suggests that approaches adopted prior to acid exposures tend to be more successful. Despite this, there is still no consensus on the efficacy of this therapeutic resource, due mainly to the lack of st...

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Influence of extra- and intra-oral application of CPP-ACP and fluoride on re-hardening of eroded enamel

Abstract: Intra-oral application of CPP-ACP crème or fluoride solution provides no benefit regarding re-hardening of erosively softened enamel.

Cited by 53 publications

References 40 publications

Randomised in situ trial on the effect of milk and CPP-ACP on dental erosion

Randomised in situ trial on the effect of milk and CPP-ACP on dental erosion

Durability of the anti-erosive effect of surfaces sealants under erosive abrasive conditions

Utilização de pastas contendo fosfopeptídeo de caseína-fosfato de cálcio amorfo com e sem fluoreto na prevenção da erosão dentária: uma revisão da literatura

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