Influence of expression of UCP3, PLIN1 and PPARG2 on the oxidation of substrates after hypocaloric dietary intervention

Oliveira, Cristiana Cortes de; Nicoletti, Carolina Ferreira; Pinhel, Marcela Augusta de Souza; Oliveira, Bruno Affonso Parenti de; Quinhoneiro, Driele Cristina Gomes; Noronha, Natália Yumi; Fassini, Priscila Giácomo; Marchini, Júlio Sérgio; Júnior, Wilson Araújo da Silva; Júnior, Wilson Salgado; Nonino, Carla Barbosa

doi:10.1016/j.clnu.2017.06.012

Cited by 4 publications

(3 citation statements)

References 43 publications

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“…It was therefore able to lead lipolysis in combination with ATGL (which almost did not change in phosphorylation level after weight loss) (see Figure 9). The increase in total PLIN1 expression after weight loss that we observed in our cohort was in accordance with previous observations in SAT obtained from adults (64,(66)(67)(68).…”

Section: All Follow-up Patients (N = 9)supporting

confidence: 93%

The omentum of obese girls harbors small adipocytes and browning transcripts

Tarabra¹,

Nouws²,

Vash‐Margita³

et al. 2020

JCI Insight

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Section: All Follow-up Patients (N = 9)supporting

confidence: 93%

The omentum of obese girls harbors small adipocytes and browning transcripts

Tarabra¹,

Nouws²,

Vash‐Margita³

et al. 2020

JCI Insight

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“…In addition, UCP3 in muscle did not influence the accumulation of intracellular lipid and mitochondrial function [61]. However, in human studies, dietary interventions aimed at reducing calorie intake for obese patients revealed a positive correlation between carbohydrate oxidation and UCP3 expression [62]. Overexpression of UCP3 in primary cultures using human muscle increased glucose and fatty acid oxidation [63].…”

Section: Discussionmentioning

confidence: 99%

Potential Role of Pig UCP3 in Modulating Adipocyte Browning via the Beta-Adrenergic Receptor Signaling Pathway

Kim,

Yazawa,

Koide

et al. 2024

Biology

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Adipose tissue plays an important role in regulating body temperature and metabolism, with white adipocytes serving as storage units for energy. Recent research focused on the browning of white adipocytes (beige adipocytes), causing thermogenesis and lipolysis. The process of browning is linked to the activation of uncoupling protein (UCP) expression, which can be mediated by the β3 adrenergic receptor pathway. Transcriptional factors, such as peroxisome proliferator activated receptor γ (PPARγ) and PPARγ coactivator 1 alpha, play vital roles in cell fate determination for fat cells. Beige adipocytes have metabolic therapeutic potential to combat diseases such as obesity, diabetes mellitus, and dyslipidemia, owing to their significant impact on metabolic functions. However, the molecular mechanisms that cause the induction of browning are unclear. Therefore, research using animal models and primary culture is essential to provide an understanding of browning for further application in human metabolic studies. Pigs have physiological similarities to humans; hence, they are valuable models for research on adipose tissue. This study demonstrates the browning potential of pig white adipocytes through primary culture experiments. The results show that upregulation of UCP3 gene expression and fragmentation of lipid droplets into smaller particles occur due to isoproterenol stimulation, which activates beta-adrenergic receptor signaling. Furthermore, PPARγ and PGC-1α were found to activate the UCP3 promoter region, similar to that of UCP1. These findings suggest that pigs undergo metabolic changes that induce browning in white adipocytes, providing a promising approach for metabolic research with potential implications for human health. This study offers valuable insights into the mechanism of adipocyte browning using pig primary culture that can enhance our understanding of human metabolism, leading to cures for commonly occurring diseases.

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“…This science also examines how a nutritional strategy affects gene expression and uses the gene expression pattern as a tool to predict responsiveness to nutritional treatments [ 56 , 77 ]. Dietary caloric restriction is sufficient to alter the expression of different genes related to resting energy expenditure and lipid metabolism and contributes to the development of strategies for obesity and weight control [ 78 , 79 , 80 ].…”

Section: Bariatric Surgery and Gene Expression Profilementioning

confidence: 99%

Bariatric Surgery and Precision Nutrition

et al. 2017

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This review provides a literature overview of new findings relating nutritional genomics and bariatric surgery. It also describes the importance of nutritional genomics concepts in personalized bariatric management. It includes a discussion of the potential role bariatric surgery plays in altering the three pillars of nutritional genomics: nutrigenetics, nutrigenomics, and epigenetics. We present studies that show the effect of each patient’s genetic and epigenetic variables on the response to surgical weight loss treatment. We include investigations that demonstrate the association of single nucleotide polymorphisms with obesity phenotypes and their influence on weight loss after bariatric surgery. We also present reports on how significant weight loss induced by bariatric surgery impacts telomere length, and we discuss studies on the existence of an epigenetic signature associated with surgery outcomes and specific gene methylation profile, which may help to predict weight loss after a surgical procedure. Finally, we show articles which evidence that bariatric surgery may affect expression of numerous genes involved in different metabolic pathways and consequently induce functional and taxonomic changes in gut microbial communities. The role nutritional genomics plays in responses to weight loss after bariatric surgery is evident. Better understanding of the molecular pathways involved in this process is necessary for successful weight management and maintenance.

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Influence of expression of UCP3, PLIN1 and PPARG2 on the oxidation of substrates after hypocaloric dietary intervention

Cited by 4 publications

References 43 publications

The omentum of obese girls harbors small adipocytes and browning transcripts

The omentum of obese girls harbors small adipocytes and browning transcripts

Potential Role of Pig UCP3 in Modulating Adipocyte Browning via the Beta-Adrenergic Receptor Signaling Pathway

Bariatric Surgery and Precision Nutrition

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