Influence of exposure in hyperbaric chambers on selected parameters of oxidative stress in professional divers

Kozakiewicz, Mariusz; Kędziora–Kornatowska, Kornelia; Kaczerska, Dorota; Siermontowski, Piotr; Olszański, Romuald; Krefft, Karolina

doi:10.22462/01.02.2018.7

Cited by 3 publications

(3 citation statements)

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“…According to these results; it is possible to deal with oxidative stress that may occur as a result of high oxygen pressure applied during HBOT, but it can be considered that HDL-related antioxidant molecules are reduced due to higher consumption of PON1/ARE enzymes. The fact that we have similar findings with a study in the literature supports this idea [9].…”

Section: Discussionsupporting

confidence: 93%

“…Firstly, this study shows that long term HBOT were also might associated with changes in HDL metabolism. Because it is known that the imbalance of free radical formation or intensive consumption of antioxidant molecules leads to relatively decreased of biological macromolecules such as serum PON1 levels [9]. A balance shifting towards increased oxidative stress in SSNHL has been recently reported [2].…”

Section: Discussionmentioning

confidence: 99%

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Compensatory Paraoxonase and Arylesterase Levels in Hyperbaric Oxygen Treatment of Sudden Sensorineural Hearing Loss

Eren

Yılmaz

Yıldırım³

et al. 2020

Polish Hyperbaric Research

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Objective: Paraoxonase1 (PON1) and Arylesterase (ARE) levels are associated with reduced risk of atherosclerosis. The functional status of high density lipoprotein (HDL) is closely related to the PON1/ARE enzyme activity. Functional changes in treatment of sudden sensorineural hearing loss (SSNHL) may be achieved by post-translational modification of lipid metabolism induced by hyperbaric oxygen therapy (HBOT).Methods: Men patients with SSNHL who met the research criteria were included in the study. HBOT was performed on average 30 sessions. Laboratory measurements were made at the beginning and end of HBOT for the same patients. Serum levels of PON1/ARE and routine lipid laboratory parameters were measured to determine possible changes in SSNHL after HBOT.Results: In this study, a reducing effect on PON1 enzyme amount of long-term HBOT was detected. The serum PON1 amount of patients with SSNHL was 19.7 ± 2.7 ng / mL (mean ± SD) before HBOT, and the serum PON1 decreased to 17.0 ± 2.1 ng / mL (mean ± SD) after 30 sessions of HBOT. This decrease in PON1 levels was statistically significant (p =0.035). There was also a statistically significant decrease in the enzyme activity of ARE in the SSNHL patients (p=0.024).Conclusion: This preliminary study showed a significant decrease in serum PON1/ARE enzyme content in SSNLH patients with HBOT. In fact, it can be assumed that HBOT has no adverse effect on HDL functionality. However, the decrease in PON1 level by HBOT with 30 or more sessions may be important for the antioxidant function of HDL.It may possibly cause post-translational changes in antioxidant defense mechanisms due to increased oxidative stress with HBOT. In conclusion, larger clinical studies are needed to determine the possible effects of HBOT on HDL-related PON1/ARE functionality in SSNHL.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Compensatory Paraoxonase and Arylesterase Levels in Hyperbaric Oxygen Treatment of Sudden Sensorineural Hearing Loss

Eren

Yılmaz

Yıldırım³

et al. 2020

Polish Hyperbaric Research

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“…Protein carbonyls [93] Carbonyl group [56] Protein carbonyl derivates [55] Plasma carbonyl proteins [83] [82] DNA/RNA damage 8-hydroxydeoxyguanosine [83] [82] Tail moment [38,94-96] [76,97,98] Sister chromatid exchange [14] Gene expression Nuclear factor erythroid 2related factor 2 [45] Other residues of oxidative stress…”

Section: Associated Markers Stimulating Effect No Effect Inhibiting Effectmentioning

confidence: 99%

The Effects of Hyperbaric Oxygenation on Oxidative Stress, Inflammation and Angiogenesis

et al. 2021

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Hyperbaric oxygen therapy (HBOT) is commonly used as treatment in several diseases, such as non-healing chronic wounds, late radiation injuries and carbon monoxide poisoning. Ongoing research into HBOT has shown that preconditioning for surgery is a potential new treatment application, which may reduce complication rates and hospital stay. In this review, the effect of HBOT on oxidative stress, inflammation and angiogenesis is investigated to better understand the potential mechanisms underlying preconditioning for surgery using HBOT. A systematic search was conducted to retrieve studies measuring markers of oxidative stress, inflammation, or angiogenesis in humans. Analysis of the included studies showed that HBOT-induced oxidative stress reduces the concentrations of pro-inflammatory acute phase proteins, interleukins and cytokines and increases growth factors and other pro-angiogenesis cytokines. Several articles only noted this surge after the first HBOT session or for a short duration after each session. The anti-inflammatory status following HBOT may be mediated by hyperoxia interfering with NF-κB and IκBα. Further research into the effect of HBOT on inflammation and angiogenesis is needed to determine the implications of these findings for clinical practice.

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Impact of Hyperbaric Stress on Lipid Composition of Blood Plasma and Physiological-Biochemical Characteristics of Erythrocytes in Divers: Prevention of Violations by Vegetable Polyphenols

Кушнерова

Rakhmanin

Momot

et al. 2019

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There was studied lipid composition of blood plasma and erythrocyte membranes, physiological characteristics of erythrocytes in divers, exposed to extreme factors of the hyperbaric environment in the process of the occupational activity. There was observed a group of 10 male divers from 25 to 30 years of age, whose work is associated with the systematic implementation of submarine dives at medium and large depths (20-60 m) using compressed air for breathing. The influence of hyperbaric stress was shown to be accompanied by the change in a ratio of fatty acids in the total lipids of blood plasma and erythrocyte membranes. In total lipids of blood plasma and erythrocyte membranes the number of all kinds of saturated fatty acids (myristic acid, palmitic acid, stearic acid), the monounsaturated fatty acids (palmitoleic acid) was increased and an amount of polyunsaturated fatty acids of n-6 family (arachidonic acid) and n-3 (eicosapentaenoic acid) was reduced, which caused a change in physicochemical properties of erythrocytes, permeability, and lability. The increase in the amount of cholesterol in the erythrocyte membranes correlates with its elevation in blood plasma. There was an increase in the volume of erythrocytes by 5% and diameter by 13%, due to the inclusion of cholesterol in the membrane. It was recorded a shift in the threshold of hemolysis start at 0.50 ± 0.02% NaCl and its completion at 0.40 ± 0.01% NaCI. Preventive administration of the Kalifen food supplement for two months before the dive would help to remove metabolic disorders caused by the hyperbaric factors.

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Influence of exposure in hyperbaric chambers on selected parameters of oxidative stress in professional divers

Cited by 3 publications

References 0 publications

Compensatory Paraoxonase and Arylesterase Levels in Hyperbaric Oxygen Treatment of Sudden Sensorineural Hearing Loss

Compensatory Paraoxonase and Arylesterase Levels in Hyperbaric Oxygen Treatment of Sudden Sensorineural Hearing Loss

The Effects of Hyperbaric Oxygenation on Oxidative Stress, Inflammation and Angiogenesis

Impact of Hyperbaric Stress on Lipid Composition of Blood Plasma and Physiological-Biochemical Characteristics of Erythrocytes in Divers: Prevention of Violations by Vegetable Polyphenols

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