Influence of exercise on serum brain-derived neurotrophic factor concentrations in healthy human subjects

Brain derived neurotrophic factor, cardiopulmonary fitness and cognition in patients with coronary artery disease

“…This is consistent with reports that physical activity can increase peripheral blood BDNF concentrations in medically healthy subjects (Seifert et al, 2010;Tang et al, 2008). However, since this effect has not been consistent in younger medically healthy and physically active subjects, the present study focused on an older and largely sedentary patient population (Goekint et al, 2010).…”

Serum Brain-Derived Neurotrophic Factor, Depression, and Antidepressant Medications: Meta-Analyses and Implications

“…This suggests that the measure may be used to screen for novel antidepressant agents or possibly even predict an individual's response to an antidepressant treatment at an early time point after treatment initiation if a relationship can be established between the change in BDNF levels and clinical response. However, it is important to recognize that plasma and serum BDNF levels have also been shown to correlate with other events and activities such as food intake (37), stress (38), and exercise (39), that are likely to complicate the interpretation of the findings and possibly limit the true utility of the measure. On the other hand, it is worthy of note that some of these conditions are known to either exacerbate or precipitate depression (e.g., stress), or produce an antidepressant response (5).…”

短跑运动员血浆中脑源性神经营养因子水平较普通人群显著升高

“…Although it is well-known that exercise increases BDNF transcription in the brain [8] , recent findings have reported that physical exercise, mostly aerobic endurance exercise, enhances circulating BDNF levels in healthy humans [9][10][11][12][13][14][15][16] . Interestingly, neither high-intensity strength exercise [17] nor general strength training [25] induces any significant changes in BDNF levels.…”