Influence of Estrogen and Osteopenia/Osteoporosis on Clinical Periodontitis in Postmenopausal Women

Reinhardt, Richard; Payne, Jeffrey B.; Maze, Connie A.; Patil, Kashinath D.; Gallagher, Steven J.; Mattson, John S.

doi:10.1902/jop.1999.70.8.823

Cited by 161 publications

(162 citation statements)

References 20 publications

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“…It was concluded that estrogen supplementation may lower gingival inflammation and rate of clinical attachment loss in osteopenic/osteoporotic population. 39 Weyant et al studied a cross-section of a large sample of osteoporotic women in the postmenopausal age. The average age of participants was 70.7 years and BMD was measured using single photon absorptiometry at the hip, spine, radius and calcaneus regions.…”

Section: Calcitoninmentioning

confidence: 99%

“…49 Again, a study by Richard A etal concluded that estrogen supplementation may lower gingival inflammation and rate of clinical attachment loss in osteopenic/osteoporotic population. 39 Future research: Currently marketed osteoporosis therapies including bisphosphonates and selective estrogen modulators are efficacious but inconvenient for the patients because of the need for frequent administration and the risk of adverse effects. The active immunization strategy against TRANCE/RANKL using C-TRANCE-VLPs may offer a safe, efficient and cost-effective new therapeutic option for the treatment of osteoporosis.…”

Section: Mechanismmentioning

confidence: 99%

See 1 more Smart Citation

Osteoporosis and Periodontal Disease: Association and Mechanisms: An in-Depth Review

Bodduru¹,

Deshmukh²,

Chintawa³

et al. 2016

IJTA

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Section: Calcitoninmentioning

confidence: 99%

Section: Mechanismmentioning

confidence: 99%

Osteoporosis and Periodontal Disease: Association and Mechanisms: An in-Depth Review

Bodduru¹,

Deshmukh²,

Chintawa³

et al. 2016

IJTA

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“…A number of studies have suggested that the risk of postmenopausal tooth loss is reduced by oestrogen replacement (43). Furthermore, lower oestrogen levels have been linked to gingival inflammation (44) and reduced clinical attachment levels (45).…”

Section: Sex Steroid Hormonesmentioning

confidence: 99%

The Effects of Menopause on Periodontal Tissue

Yi̇ldi̇ri̇m

Kaya

2011

Int Dent Res

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Periodontitis and gingivitis, a prevalent oral diseases, have been connected to several systemic health changes. The aim of this investigation was to review the effects of menopause on periodontal tissue. Epidemiologic studies have identified a number of risk factors and risk indicators for periodontal attachment loss, including demographic, socioeconomic, behavioural, genetic, and systemic factors. Menopause has also been associated with destructive periodontal disease in older women. The homeostasis of the periodontium involves complex multifactorial relationships. Oestrogen and progesterone are responsible for physiological changes in women at specific phases of their life. Menopause is associated with significant adverse changes in the orofacial complex.

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“…No entanto, analisando os grupos de mulheres estrógeno suficientes e deficientes, os parâmetros periodontais não mostraram tal associação, como apresentado em estudos semelhantes 13,16,21 . Estes estudos concluíram que a osteopenia na pós-menopausa constitui fator de risco para a doença periodontal.…”

Section: Densitometria óSsea Mineralunclassified

Menopausa: fator de risco para doença periodontal?

Pallos

Ceschin²,

Victor

et al. 2006

Rev. Bras. Ginecol. Obstet.

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Objetivo: verificar se existe relação entre os parâmetros periodontais e os níveis de estrógeno e densitometria óssea mineral (DOM). Métodos: foram avaliadas 46 mulheres na pós-menopausa entre 44 e 68 anos de idade (52,2±4,8) e 15 mulheres como grupo controle entre 35 e 54 anos de idade (44,7±7,5). Parâmetros periodontais como profundidade à sondagem (PS), perda de inserção clínica (PIC) e dentes ausentes (DA) foram comparados com os níveis de estrógeno (suficiente e deficiente) e DOM em normais, osteopênicas e osteoporóticas. Os dados foram comparados pela diferença das médias entre os grupos e analisados pelo teste de Aspin-Welch. Resultados: as médias dos parâmetros de PS, PIC e DA, quando associados ao grau da DOM em normais (2,1±0,5; 2,9±1,4 e 10,6±5,0), osteopênicas (2,3±0,7; 3,0±1,1 e 12,8±5,1) e osteoporóticas (2,4±0,6; 2,7±0,9 e 14,3±5,7), não mostraram diferenças significativas (p>0,05). Foi encontrada diferença significante entre o grupo controle e nas mulheres menopausadas para PIC e DA. Quando comparados com os níveis de estrógeno os resultados demonstraram igualdade para os parâmetros periodontais. Conclusões: apesar de alguns estudos demonstrarem correlação positiva da doença periodontal com osteoporose e com os níveis de estrogênio, na população de mulheres menopausadas estes dados não foram confirmados neste estudo. PALAVRAS-CHAVE:Periodontite; Menopausa; Densitometria; Estrógeno ABSTRACT Purpose: to verify if there is a relationship between the clinical periodontal parameters and estrogen levels and bone mineral density (BMD). Methods: forty-six post-menopausal women aged 44 to 68 years (52.2±4.8) and 15 women aged 35 to 54 years (44.7±7.5) were evaluated. Periodontal parameters like probing depth (PD), clinical attachment loss (CAL), and missing teeth (MT) were compared with estrogen levels (sufficient and insufficient) and BMD (normal, osteopenic and osteoporotic). Data of the mean difference between the groups were compared by the Aspin-Welch test. Results: the means of PD, CAL and MT, when associated with the normal (2.1±0.5; 2.9±1.4 and 10.6±5.0), osteopenic (2.3±0.7; 3.0±1.1 and 12.8±5.1) and osteoporotic BMD (2.4±0.6; 2.7±0.9 and 14.3±5.7), did not show statistical difference (p>0.05). A significant difference was found between the control group and postmenopausal women for CAL and MT. When compared with the estrogen levels the results did not show a difference regarding the periodontal parameters. Conclusion: although some studies showed a positive correlation with osteoporosis and estrogen level, in this population of menopausal women these findings were not confirmed.

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Influence of Estrogen and Osteopenia/Osteoporosis on Clinical Periodontitis in Postmenopausal Women

Abstract: These data suggest that E2 supplementation (serum E2>40 pg/ml) is associated with reduced gingival inflammation and a reduced frequency of clinical attachment loss in osteopenic/osteoporotic women in early menopause.

Cited by 161 publications

References 20 publications

Osteoporosis and Periodontal Disease: Association and Mechanisms: An in-Depth Review

Osteoporosis and Periodontal Disease: Association and Mechanisms: An in-Depth Review

The Effects of Menopause on Periodontal Tissue

Menopausa: fator de risco para doença periodontal?

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