Influence of epicardial adipose tissue and adipocytokine levels on cardiac abnormalities in visceral obesity

Malavazos, Alexis Elias; Ermetici, Federica; Coman, C; Corsi, Massimiliano M.; Morricone, Lelio; Ambrosi, Bruno

doi:10.1016/j.ijcard.2006.08.061

Cited by 74 publications

(61 citation statements)

References 15 publications

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“…In this study, we used the echocardiographic epicardial fat as marker of visceral adiposity, as previous studies from our group (7,12,14,20) and also from other authors (8,21) showed.…”

confidence: 99%

Substantial Changes in Epicardial Fat Thickness After Weight Loss in Severely Obese Subjects

Iacobellis

Singh

Wharton

et al. 2008

Obesity

203

164

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We sought to evaluate the effect of weight loss on echocardiographic epicardial fat thickness, as index of visceral adiposity, and whether epicardial fat change after the weight loss can be proportionally different from overall body weight changes and related to cardiac parameters changes in severely obese subjects. This was an interventional study in 20 severely obese subjects (12 women, 8 men, BMI 45 ± 5 kg/m 2 , 35 ± 10 years) who underwent 6-month very low calorie diet weight loss program. Baseline and after 6-month weight loss anthropometrics, echocardiographic epicardial fat thickness, left ventricular mass (LVM), and diastolic function parameters were assessed. Subjects lost 20% of original body weight, BMI reduced by 19% of original BMI, waist circumference decreased by 23% of initial waist circumference. Epicardial fat thickness decreased from 12.3 ± 1.8 to 8.3 ± 1 mm P < 0.001 after the 6-month very low calorie diet, as −32% of baseline epicardial fat thickness. LVM and diastolic function changes were better correlated with epicardial fat changes. We showed that significant weight loss can be associated with significant reduction in the epicardial fat thickness, marker of visceral adiposity in severely obese subjects. Epicardial fat decrease, therefore visceral fat decrease, can be proportionally higher than overall adiposity decrease. Epicardial fat changes are significantly associated with obesity-related cardiac morphological and functional changes during weight loss. Measurement of echocardiographic epicardial fat thickness may provide an additional tool in understanding the metabolic risk associated with variation in fat distribution.

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“…In this study, we used the echocardiographic epicardial fat as marker of visceral adiposity, as previous studies from our group (7,12,14,20) and also from other authors (8,21) showed.…”

confidence: 99%

Substantial Changes in Epicardial Fat Thickness After Weight Loss in Severely Obese Subjects

Iacobellis

Singh

Wharton

et al. 2008

Obesity

203

164

View full text Add to dashboard Cite

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“…La grasa epicárdica es una fuente importante de mediadores inflamatorios y adipocitoquinas, que pueden producir directamente remodelado eléctrico y estructural de la aurícula 37 . Malavazos et al, demostraron que los niveles de proteína quimiotáctica de los monocitos 1 y del complejo IL-6/receptor soluble de IL-6 se correlacionan estrechamente con el espesor de la grasa epicárdica 38 y Kremen et al, detectaron altas concentraciones de citokinas inflamatorias en la grasa epicárdica de pacientes sometidos a cirugía cardíaca 39 . Dado que la grasa epicárdica está en contacto directo con la AI y las venas pulmonares, su rol puede ser clave en la iniciación de la FA.…”

Section: Discussionunclassified

Strain y Strain rate auricular izquierdo evaluado por speckle tracking está relacionado a PCR ultrasensible en adolescentes obesos

et al. 2011

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Resumen: Introducción:La obesidad y el síndrome metabólico están asociados a un tamaño auricular izquierdo (AI) aumentado y mayor riesgo cardiovascular. El strain y strain rate longitudinal determinado por speckle tracking son herramientas novedosas en la evaluación de la función AI.Objetivo: evaluar el strain y strain rate AI en adolescentes obesos y su relación con biomarcadores de riesgo cardiovascular.Métodos: se incluyeron adolescentes consecutivos con un z-índice de masa corporal (z-IMC) > 1 en ritmo sinusal sin otra comorbilidad y un grupo control pareado por edad y sexo. Se registraron las caracterís-ticas clínicas y ecocardiográficas con evaluación del strain AI: onda s (LASs), onda a (LASa) y strain rate AI: onda s (LASRs), onda a (LASRa) por speckle tracking. Se midió adiponectina y PCR ultrasensible.Se utilizó t-Student, chi-cuadrado y correlación de Pearson.Resultados: Se incluyeron 15 sujetos por grupo de edad promedio de 13 años, 47% hombres sin diferencia entre ambos grupos. Los pacientes con sobrepeso presentaron significativamente mayores niveles de PCR us respecto del grupo control, 0,5 ± 0,1 mg/L vs 1,4 ± 0,3, p = 0,04 y menores de LASs (44 ± 1,8 vs 32 ± 1,1%;p<0,01), LASa ( -1,7 ± 0,3 vs -0,7 ± 0,3 1/s; p<0,01), LASRs ( 1,7 ± 0,07 vs 1,3 ± 0,03%; p<0,01), LASRa (-1,8 ± 0,1 vs -1,2 ± 0,08 1/s;p<0,01). En el grupo con sobrepeso se encontró una correlación negativa significativa entre LASs, LASRs y PCR ultrasensible (R: -0,62; p < 0,01 y R: -0,58: p = 0,02 respectivamente). Conclusiones:El strain y strain rate AI se encuentran reducidos en adolescentes obesos y estos paráme-tros de función AI se correlacionan con un estado inflamatorio aumentado. La importancia clínica de estos hallazgos requieren mayor investigación.

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“…Furthermore, it has been reported that adiponectin may play a role in the phosphorylation of eNOS [24] and reduced adiponectin, which is often recognized in MS patients, may lead to endothelial dysfunction. In addition, it has been reported that pericardial fat tissue, which is increased in MS patients, discharges several cytokines systemically and locally [25,26] , indicating the possibility that impairment of coronary endothelial function may be caused by pericardial fat tissue. These mechanisms may solely and/or multifactorially contr ibute to coronary endothelial dysfunction in MS patients.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have revealed that MS is a factor that may be responsible for future cardiovascular events, independent of racial differences [26] . Studies have also indicated the presence of endothel ial dysfunction assessed using several modalities, such as positron emission tomography, flowmediated dilation in the brachial artery, and venous occlusion plethysmography, in MS patients [713] .…”

Section: Introductionmentioning

confidence: 99%

Impaired coronary microvascular endothelial function in men with metabolic syndrome

Teragawa

Matsumoto²,

Nishioka³

et al. 2010

WJC

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AIM:To assess coronary endothelial function of conduit and resistance vessels in patients with metabolic syndrome (MS). METHODS:Seventy-eight men (mean age, 57 years) with chest pain and angiographically normal coronary arteries were included in the study. Patients with coronary spastic angina were excluded. Changes in coronary artery diameter and coronary blood flow (CBF) in response to acetylcholine (ACh) were determined using quantitative coronary angiography and Doppler velocity measurements. Coronary flow reserve was calculated as the ratio of coronary blood velocity after adenosine triphosphate infusion relative to baseline values. Patients were divided into two groups based on the presence or absence of MS. RESULTS: There were 24 patients in the MS group (31%).The increase in CBF in response to ACh infusion was impaired in the MS group (P < 0.0001) compared to the non-MS group, whereas changes in coronary artery diameter in response to ACh infusion did not differ between the two groups. Multivariate regression analysis revealed that MS was a significant factor associated with the lesser change in CBF induced by ACh infusion at 30 μg/min (P < 0.0001, r 2 = 0.46). CONCLUSION:Coronary endothelial dysfunction was present at the level of resistance vessels but not conduit vessels in the MS patients included in our study.

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Influence of epicardial adipose tissue and adipocytokine levels on cardiac abnormalities in visceral obesity

Cited by 74 publications

References 15 publications

Substantial Changes in Epicardial Fat Thickness After Weight Loss in Severely Obese Subjects

Substantial Changes in Epicardial Fat Thickness After Weight Loss in Severely Obese Subjects

Strain y Strain rate auricular izquierdo evaluado por speckle tracking está relacionado a PCR ultrasensible en adolescentes obesos

Impaired coronary microvascular endothelial function in men with metabolic syndrome

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