Influence of enrichment on behavioral and neurogenic effects of antidepressants in Wistar rats submitted to repeated forced swim test

Possamai, Fernanda; Santos, Juliano dos; Walber, Thais; Marcon, Juliana C.; Santos, Tiago Souza dos; Oliveira, Cilene Lino de

doi:10.1016/j.pnpbp.2014.10.017

Cited by 28 publications

(26 citation statements)

References 35 publications

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“…For instance, many studies show that SSRI administration reduces depression-like behavior, 5, 6 enhances neurogenesis, 7 increases brain-derived neurotrophic factor (BDNF) levels, 5, 8 reduces hypothalamic–pituitary–adrenal (HPA) axis activity 9, 10 and heightens long-term potentiation (LTP). 11 However, many others reported no or opposite effects concerning the same endpoints: behavior, 12, 13, 14, 15 neurogenesis, 16, 17, 18, 19, 20 BDNF levels, 21, 22, 23, 24, 25, 26 HPA axis activity 27, 28 and LTP. 29, 30 …”

Section: Introductionmentioning

confidence: 99%

Fluoxetine effects on molecular, cellular and behavioral endophenotypes of depression are driven by the living environment

et al. 2015

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Selective serotonin reuptake inhibitors (SSRIs) represent the most common treatment for major depression. However, their efficacy is variable and incomplete. In order to elucidate the cause of such incomplete efficacy, we explored the hypothesis positing that SSRIs may not affect mood per se but, by enhancing neural plasticity, render the individual more susceptible to the influence of the environment. Consequently, SSRI administration in a favorable environment promotes a reduction of symptoms, whereas in a stressful environment leads to a worse prognosis. To test such hypothesis, we exposed C57BL/6 mice to chronic stress in order to induce a depression-like phenotype and, subsequently, to fluoxetine treatment (21 days), while being exposed to either an enriched or a stressful condition. We measured the most commonly investigated molecular, cellular and behavioral endophenotypes of depression and SSRI outcome, including depression-like behavior, neurogenesis, brain-derived neurotrophic factor levels, hypothalamic–pituitary–adrenal axis activity and long-term potentiation. Results showed that, in line with our hypothesis, the endophenotypes investigated were affected by the treatment according to the quality of the living environment. In particular, mice treated with fluoxetine in an enriched condition overall improved their depression-like phenotype compared with controls, whereas those treated in a stressful condition showed a distinct worsening. Our findings suggest that the effects of SSRI on the depression- like phenotype is not determined by the drug per se but is induced by the drug and driven by the environment. These findings may be helpful to explain variable effects of SSRI found in clinical practice and to device strategies aimed at enhancing their efficacy by means of controlling environmental conditions.

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Section: Introductionmentioning

confidence: 99%

Fluoxetine effects on molecular, cellular and behavioral endophenotypes of depression are driven by the living environment

et al. 2015

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“…In particular, imipramine and fluoxetine reverted the decrease in cell proliferation in both the SGZ and SVZ in several stress models of depression (Keilhoff et al, 2006;Hitoshi et al, 2007;Diniz et al, 2013;Fenton et al, 2015;Possamai et al, 2015). Atypical antipsychotic drugs, such as olanzapine and clozapine, which have been clinically used in combination with antidepressants for the treatment of refractory depression, have been also reported to stimulate cell proliferation in both neurogenic areas, i.e., SVZ and SGZ (Kodama et al, 2004;Halim et al, 2004;Wakade et al, 2002).…”

Section: Discussionmentioning

confidence: 97%

Influence of single and repeated cannabidiol administration on emotional behavior and markers of cell proliferation and neurogenesis in non-stressed mice

Schiavon

Bonato

Milani

et al. 2016

Progress in Neuro-Psychopharmacology and Biological Psychiatry

112

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“…In contrast, the antidepressive effects of enrichment remain controversial. While there are reports that even a short 7-day period of environmental enrichment reduces forced-swim test (FST) immobility time in rats (Zanca et al, 2015), other evidence in rats and mice suggest that EE does not alter latency to immobility and total immobility time in the FST (Leger et al, 2015;Possamai et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Paternal environmental enrichment transgenerationally alters affective behavioral and neuroendocrine phenotypes

Yeshurun

Short

Bredy

et al. 2017

Psychoneuroendocrinology

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1016/j.psyneuen.2016.11.013 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractRecent studies have demonstrated that paternal stress in rodents can result in modification of offspring behavior. Environmental enrichment, which enhances cognitive stimulation and physical activity, modifies various behaviors and reduces stress responses in adult rodents. We investigated the transgenerational influence of paternal environmental enrichment on offspring behavior and physiological stress response. Adult C57BL/6J male mice (F0) were exposed to either environmental enrichment or standard housing for four weeks and then pair-mated with naïve females. The F2 generation was generated using F1 male offspring. Male and female F1 and F2 offspring were tested for anxiety using the elevated-plus maze and large open field at 8 weeks of age. Depression-related behavior was assessed using the forced-swim test. Hypothalamic-pituitary-adrenal (HPA) axis function was determined by quantification of serum corticosterone and adrenocorticotropic hormone (ACTH) levels at baseline and after forced-swim stress. Paternal environmental enrichment was associated with increased body weights of male F1 and F2 offspring. There was no significant effect on F1 offspring anxiety and depression-related behaviors. There were no changes in anxietyrelated behaviors in the F2 offspring, however these mice displayed a reduced latency to immobility in the forced-swim test. Furthermore, F2 females had significantly higher serum corticosterone levels post-stress, but not ACTH. These results show that paternal environmental enrichment exerts a sex-specific transgenerational impact on the behavioral and physiological response to stress. Our findings have implications for the modelling of psychiatric disorders in rodents.

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Influence of enrichment on behavioral and neurogenic effects of antidepressants in Wistar rats submitted to repeated forced swim test

Cited by 28 publications

References 35 publications

Fluoxetine effects on molecular, cellular and behavioral endophenotypes of depression are driven by the living environment

Fluoxetine effects on molecular, cellular and behavioral endophenotypes of depression are driven by the living environment

Influence of single and repeated cannabidiol administration on emotional behavior and markers of cell proliferation and neurogenesis in non-stressed mice

Paternal environmental enrichment transgenerationally alters affective behavioral and neuroendocrine phenotypes

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