Influence of engineered titania nanotubular surfaces on bone cells

Popat, Ketul C.; Leoni, Lara; Grimes, Craig A.; Desai, Tejal A.

doi:10.1016/j.biomaterials.2007.03.020

Cited by 556 publications

(480 citation statements)

References 31 publications

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“…Bone tissue injury initiates a cascade of events leading to the migration of neutrophils, macrophages, and fibroblasts, which subsequently express and secrete a variety of cytokines and transcriptional factors which direct MSC migration, protein adsorption, cell adhesion, neovascularization, fibrosis, and remodeling/healing. [102][103][104][105][106] Bone dimensional hierarchy…”

Section: Chemical Cues In Bonementioning

confidence: 99%

“…Examples of successful 2D and 3D nanofabrication techniques include electrospinning, [195][196][197][198][199] nanotemplating, 179,200 electrostatic spray deposition, 201,202 RF plasma spray/deposition, 203 molecular self assembly, [204][205][206] and metal oxide anodization. 104,182,[207][208][209] Of the fabrication techniques listed above, electrospinning has emerged as a very promising strategy for fabricating bone-mimetic nanofiber scaffolds. The popularity of electrospinning is likely due to the simplicity of the experimental setup, the ability to incorporate bioactive molecules, and the versatility is provides.…”

Section: Physical Effectors In Synthetic Bone Scaffoldsmentioning

confidence: 99%

“…195,214,215 Templating is another fabrication technique which is capable of developing multidimensional structures. 104,182,200,213 Other techniques such as modified rapid prototyping, 216 electrochemical anodization, template synthesis, and polymer-mineral emulsion have also demonstrated the ability to construct multiscale synthetic scaffolds.…”

Section: Physical Effectors In Synthetic Bone Scaffoldsmentioning

confidence: 99%

See 2 more Smart Citations

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Porter

Ruckh

Popat

2009

Biotechnology Progress

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674

499

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Critical‐sized defects in bone, whether induced by primary tumor resection, trauma, or selective surgery have in many cases presented insurmountable challenges to the current gold standard treatment for bone repair. The primary purpose of a tissue‐engineered scaffold is to use engineering principles to incite and promote the natural healing process of bone which does not occur in critical‐sized defects. A synthetic bone scaffold must be biocompatible, biodegradable to allow native tissue integration, and mimic the multidimensional hierarchical structure of native bone. In addition to being physically and chemically biomimetic, an ideal scaffold is capable of eluting bioactive molecules (e.g., BMPs, TGF‐βs, etc., to accelerate extracellular matrix production and tissue integration) or drugs (e.g., antibiotics, cisplatin, etc., to prevent undesired biological response such as sepsis or cancer recurrence) in a temporally and spatially controlled manner. Various biomaterials including ceramics, metals, polymers, and composites have been investigated for their potential as bone scaffold materials. However, due to their tunable physiochemical properties, biocompatibility, and controllable biodegradability, polymers have emerged as the principal material in bone tissue engineering. This article briefly reviews the physiological and anatomical characteristics of native bone, describes key technologies in mimicking the physical and chemical environment of bone using synthetic materials, and provides an overview of local drug delivery as it pertains to bone tissue engineering is included. © 2009 American Institute of Chemical Engineers Biotechnol. Prog., 2009

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Section: Chemical Cues In Bonementioning

confidence: 99%

Section: Physical Effectors In Synthetic Bone Scaffoldsmentioning

confidence: 99%

Section: Physical Effectors In Synthetic Bone Scaffoldsmentioning

confidence: 99%

See 1 more Smart Citation

Bone tissue engineering: A review in bone biomimetics and drug delivery strategies

Porter

Ruckh

Popat

2009

Biotechnology Progress

Self Cite

674

499

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“…3.). Several in vitro studies have demonstrated that cells cultured on these nanotubular surfaces showed higher adhesion, proliferation, ALP activity and bone matrix deposition (Oh et al, 2006;Popat et al, 2007a). These increased in vitro cellular activities for titania nanotubes also translated to in vivo bone bonding.…”

Section: Nanotopographical Modification Of Titanium Surfacesmentioning

confidence: 99%

Osseointegration and Bioscience of Implant Surfaces - Current Concepts at Bone-Implant Interface

Ramazanoğlu¹,

Oshida²

2011

Implant Dentistry - A Rapidly Evolving Practice

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“…Research on biomedical applications of both porous alumina, and along the same lines nanotubular titania (TiO 2 ) [12][13][14][15][16][17][18], has increased tremendously in the past few years. It is well known that titania nanotube surfaces elicit favorable properties for bone cell growth and mineralization in vitro [16,18], osseointegration (bone/implant interface bonding) in vivo [19], enhance differentiation of mesenchymal stem cells toward osteogenic maturation [17], as well as elicit long term drug release [15].…”

Section: Introductionmentioning

confidence: 99%