Influence of elevated alkalinity and natural organic matter (NOM) on tissue-specific metal accumulation and reproductive performance in fathead minnows during chronic, multi-trophic exposures to a metal mine effluent

Ouellet, Jacob D.; Dubé, Monique G.; Niyogi, Som

doi:10.1016/j.ecoenv.2013.05.027

Cited by 11 publications

(4 citation statements)

References 46 publications

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“…The free radicals was accumulated to a certain level and exceed the elimination limit in the body, oxidative stress will be exerted on the fish body leading to oxidative damage. Salinity has mainly effect on body immunity, body penetration regulation, and tissue structure of fish [10]. For the salinized fish, the body can still maintain good growth performance and immune function within a controlled certain range of salinity, but when the salinity exceeds the tolerance limit of the aquatic animal, it will affect the metabolism of aquatic animal resulting to the serious toxic effect, even death.…”

Section: Discussionmentioning

confidence: 99%

“…The adjustment of osmotic pressure requires a large amount of energy causing the energy used for growth is relatively reduced, which leads to slow metabolism, decreased physique, and decreased immunity of fish [8,9]. When fish are raised in alkalinity water, a large quantity of mucus is produced, and even mortality [10]. In spite of the aquaculture skillfulness of salinealkaline waters has attained tremendous advance, a mass of saline-alkali water assets still not achieve economical fish agriculture and make the best of them [11,12].…”

Section: F I G U R Ementioning

confidence: 99%

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High‐throughput metabolomics method based on liquid chromatography‐mass spectrometry: Insights into the underlying mechanisms of salinity–alkalinity exposure‐induced metabolites changes in Barbus capito

Sun

Han

Yao

et al. 2020

J of Separation Science

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It is critical to investigate the adaptive development and the physiological mechanism of fish in external stimulation. In this study, the response of Barbus capito to salinity–alkalinity exposure was explored by high‐throughput nontargeted and liquid chromatography–mass spectrometry‐based metabolomics to investigate metabolic biomarker and pathway changes. Meanwhile, the biochemical indexes of Barbus capito were measured to discover the chronic impairment response to salinity–alkalinity exposures. A total of 29 tissue metabolites were determined to deciphering the endogenous metabolic changes of fishes during the different concentration salinity–alkalinity exposures environment, which were mainly involved in the key metabolism including the phenylalanine, tyrosine, and tryptophan biosynthesis, arachidonic acid metabolism, pyruvate metabolism, citrate cycle, and glycerophospholipid metabolism. Finally, we found the amino acid metabolism as key target was associated with the endogenous metabolites and metabolic pathways of Barbus capito to salinity–alkalinity exposures. In conclusion, metabolomics is a potentially powerful tool to reveal the mechanism information of fish in various exposure environments.

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Section: Discussionmentioning

confidence: 99%

Section: F I G U R Ementioning

confidence: 99%

High‐throughput metabolomics method based on liquid chromatography‐mass spectrometry: Insights into the underlying mechanisms of salinity–alkalinity exposure‐induced metabolites changes in Barbus capito

Sun

Han

Yao

et al. 2020

J of Separation Science

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“…Through an experiment of sodium bicarbonate alkalinity stress, the gill filament of L. waleckii became fuller, the gill lamella became longer as well as the interval between lamellae became larger (Shan et al, 2020). When fish are exposed to water with high alkalinity, the surface of fish would secrete a lot of mucus, resulting in hemorrhoids bleeding and even death occur (Tiffany et al, 2009;Ouellet et al, 2013). Sun et al (2020) reported that carbonate alkalinity can change the normal metabolism of crucian in terms of changing the osmotic pressure regulation capacity, antioxidant capacity, ammonia metabolism at low concentrations, and as the concentration of alkalinity increases, various metabolic processes are inhibited, causing chronic damage to the body (Sun et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Comparative Transcriptomic and Proteomic Analysis of Exopalaemon carinicauda in Response to Alkalinity Stress

Qin

Wang

et al. 2021

Front. Mar. Sci.

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Saline-alkaline waters are stressful environments where most aquatic animals can’t survive normally, and alkalinity is one of the key limited environmental factors. Due to strong adaptability to environment, the ridgetail white prawn Exopalaemon carinicauda is a potential good species suitable for large-scale culture in saline-alkaline waters. Exploring its alkaline adaptability mechanism will help to guide more marine crustaceans to saline-alkaline culture. In this study, an integrative analysis of the gill-specific transcriptome and proteome at 0, 12, and 36 h after alkalinity stress was performed to identify important regulators and pathways involved in alkalinity adaption of E. carinicauda. A total of 3,157 differentially expressed genes (DEGs) and 443 differentially expressed proteins (DEPs) were identified at 12 and 36 h compared with 0 h. Base on the transcriptome analysis, the Gene Ontology (GO) enriched terms were mainly related to ion transport, including “calcium-transporting ATPase activity,” “ATPase coupled ion transmembrane transporter activity,” “divalent inorganic cation transmembrane transporter activity,” etc., and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways mainly refer to the processes of endocrine system at both 12, and 36 h. Based on the proteomic analysis, KEGG pathways related to lipolysis and amino acids metabolism were significantly enriched at 12 h, and carbohydrate metabolism and immune response were significantly enriched at 36 h. There were significantly up-regulated expressions of ion transport related genes including aquaporin, carbonic anhydrase, ammonium transporter Rh type A-like, Na+/H+-exchanger, etc., as well as ion transport proteins including V-type proton ATPase 116 kDa subunit a-like isoform X1, sodium-potassium ATPase beta, vesicle associated membrane protein, etc. after alkalinity exposure, which indicating their important roles in response to alkalinity stress. The results of integrated analysis between proteome and transcriptome showed that up-regulated DEG/DEP (aldehyde dehydrogenase) was significantly enriched at 12 h and the up-regulated DEG/DEP (peptidylglycine alpha) was significantly enriched at 36 h, suggesting the two molecules may be critical in response to alkalinity change. This study reveals the first time-course, gill-specific, combined transcriptomic and proteomic profiling associated with alkalinity adaption of E. carinicauda and provides new insights into the mechanisms underlying the molecular response to alkalinity stress in shrimp.

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“…When sh are exposed to water with excessive alkalinity, a large amount of mucus is secreted on the surface of the sh; bleeding hemorrhoids and even death occur. 8,9 Carbonate salts are the most abundant kind of salt in freshwater; these include bicarbonates and carbonates. Since carbonate salts have low solubility in water, water is mainly bicarbonate.…”

Section: Introductionmentioning

confidence: 99%

Exploring the metabolic biomarkers and pathway changes in crucian under carbonate alkalinity exposure using high-throughput metabolomics analysis based on UPLC-ESI-QTOF-MS

et al. 2020

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Influence of elevated alkalinity and natural organic matter (NOM) on tissue-specific metal accumulation and reproductive performance in fathead minnows during chronic, multi-trophic exposures to a metal mine effluent

Cited by 11 publications

References 46 publications

High‐throughput metabolomics method based on liquid chromatography‐mass spectrometry: Insights into the underlying mechanisms of salinity–alkalinity exposure‐induced metabolites changes in Barbus capito

High‐throughput metabolomics method based on liquid chromatography‐mass spectrometry: Insights into the underlying mechanisms of salinity–alkalinity exposure‐induced metabolites changes in Barbus capito

Comparative Transcriptomic and Proteomic Analysis of Exopalaemon carinicauda in Response to Alkalinity Stress

Exploring the metabolic biomarkers and pathway changes in crucian under carbonate alkalinity exposure using high-throughput metabolomics analysis based on UPLC-ESI-QTOF-MS

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