Influence of drug-related problems on length of hospital stay of women with a history of preeclampsia: A multicenter study

Góes, Aline Santana; Oliveira, Alex Santana; Andrade, Tâmara Natasha Gonzaga de; Alves, Bárbara Manuella Cardoso Sodré; Neves, Sabrina Joany Felizardo; Dias, Júlia Maria Gonçalves; Júnior, Divaldo Pereira de Lyra; Filho, Alfredo Dias de Oliveira

doi:10.1016/j.preghy.2021.11.005

Cited by 2 publications

(4 citation statements)

References 31 publications

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“…The risk of prolonged maternal hospitalization was significantly higher among women with preeclampsia/eclampsia. According to Goes et al, the latter results have been associated with the incorrect use of antihypertensive drugs during pregnancy 21 .…”

Section: Discussionmentioning

confidence: 99%

Maternal-fetal outcomes of women with hypertensive disorders of pregnancy

Xavier,

Simões,

Oliveira

et al. 2023

Rev. Assoc. Med. Bras.

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SUMMARY OBJECTIVE: The objective of this study was to determine adverse maternal and perinatal outcomes in pregnant women with hypertensive disorders of pregnancy. METHODS: An analytical cross-sectional study was conducted on women admitted with hypertensive disorders of pregnancies to a university maternity hospital from August 2020 to August 2022. Data were collected using a pretested structured questionnaire. Variables associated with adverse maternal and perinatal outcomes were compared using multivariable binomial regression. RESULTS: Of 501 women with pregnancies, 2, 35, 14, and 49% had eclampsia, preeclampsia, chronic hypertension, and gestational hypertension, respectively. Women with preeclampsia/eclampsia had significantly higher risks of cesarean section (79.4 vs. 65%; adjusted RR, 2,139; 95%CI, 1,386–3,302; p=0.001) and preterm delivery at <34 weeks’ gestation (20.5 vs. 6%; adjusted RR, 2.5; 95%CI, 1.19–5.25; p=0.01) than those of women with chronic/gestational hypertension. Risks of prolonged maternal hospitalization (43.9 vs. 27.1%), neonatal intensive care unit admission (30.7 vs. 19.8%), and perinatal mortality (23.5 vs. 11.2%) were higher among women with preeclampsia/eclampsia. CONCLUSIONS: Women with preeclampsia/eclampsia had a higher risk of adverse maternal and neonatal outcomes than those with chronic or gestational hypertension. This major maternity care center requires strategies for preventing and managing preeclampsia/eclampsia to improve pregnancy outcomes.

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Section: Discussionmentioning

confidence: 99%

Maternal-fetal outcomes of women with hypertensive disorders of pregnancy

Xavier,

Simões,

Oliveira

et al. 2023

Rev. Assoc. Med. Bras.

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“…Additionally, longer hospitalization, greater number of prescribed medications and history of drug allergy presented an increased risk for the occurrence of DRPs. Other authors have also identified longer hospital stays and greater use of medications as risk factors for the occurrence of DRPs in pregnant and postpartum women [8,10]. This is justified by the higher exposure to medications which is also observed in general hospitals [32].…”

Section: Plos Onementioning

confidence: 99%

“…In two Norwegian maternity hospitals, Smedberg et al [9], investigated the occurrence of DRPs (PCNE classification) in pregnant women (at least one DRP in 42% of pregnant women), but reported on the drugs used at home only. A Brazilian cross-sectional study conducted in two maternity hospitals with 600 women, detected the main DRPs (PCNE classification) were related to medication not being administered, untreated problems and therapeutic ineffectiveness, however, only puerperal women were evaluated [10].…”

Section: Plos Onementioning

confidence: 99%

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Drug-related problems in hypertension and gestational diabetes mellitus: A hospital cohort

et al. 2023

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Objective To characterize the drug-related problems (DRPs) in high-risk pregnant women with hypertension and gestational diabetes mellitus according to frequency, type, cause, and factors associated with their occurrence in the hospital setting. Methodology This is an observational, longitudinal, prospective study that included 571 hospitalized pregnant women with hypertension and gestational diabetes mellitus using at least one medication. DRPs were classified according to the Classification for Drug-Related Problems (PCNE V9.00). In addition to descriptive statistics, a univariate and multivariate logistic regression model was employed to determine the factors associated with the DRPs. Results A total of 873 DRPs were identified. The most frequent DRPs were related to therapeutic ineffectiveness (72.2%) and occurrence of adverse events (27.0%) and the main drugs involved were insulins and methyldopa. These were followed in the first five days of treatment by: the ineffectiveness of insulin (24.6%), associated with underdosage (12.9%) or insufficient frequency of administration (9.5%) and methyldopa associated with the occurrence of adverse reactions (40.2%) in the first 48h. Lower maternal age (OR 0.966, 95% CI 0.938–0.995, p = 0.022), lower gestational age (OR 0.966, 95% CI 0.938–0.996, p = 0.026), report of drug hypersensitivity (OR 2.295, 95% CI 1.220–4.317, p = 0.010), longer treatment time (OR 1.237, 95% CI: 1.147–1.333, p = 0.001) and number of prescribed medications (OR 1.211, 95% CI: 0.240–5.476, p = 0.001) were risk factors for occurrence of DRPs. Conclusion DRPs are frequent in pregnant women with hypertension and gestational diabetes mellitus, and they are mainly related to therapeutic ineffectiveness and the occurrence of adverse events.

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Influence of drug-related problems on length of hospital stay of women with a history of preeclampsia: A multicenter study

Cited by 2 publications

References 31 publications

Maternal-fetal outcomes of women with hypertensive disorders of pregnancy

Maternal-fetal outcomes of women with hypertensive disorders of pregnancy

Drug-related problems in hypertension and gestational diabetes mellitus: A hospital cohort

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