Influence of dorzolamide on corneal thickness, endothelial cell count and corneal sensibility

Kaminski, S.; Hommer, Anton; Koyuncu, Didem; Biowski, Robert; Barisani, T.; Baumgartner, Isabella

doi:10.1034/j.1600-0420.1998.760114.x

Cited by 59 publications

(44 citation statements)

References 7 publications

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“…In light of the extensive clinical experience with these medications, our findings are not surprising. Previous studies of various glaucoma drops in humans also have not found a deleterious effect on endothelial cell density, 9,[20][21][22] corneal deswelling rates, 12,21 or fluorescein permeability. 23 In contrast, some animal studies have suggested that the ultrastructure of the endothelium changes after chronic use of glaucoma medications.…”

Section: Discussionmentioning

confidence: 81%

Effects of Glaucoma Medications on Corneal Endothelium, Keratocytes, and Subbasal Nerves Among Participants in the Ocular Hypertension Treatment Study

Baratz

Nau

Winter

et al. 2006

Cornea

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Purpose: To compare subbasal corneal nerve and keratocyte density and endothelial characteristics of ocular hypertensive patients treated with medications or observation. Methods: Participants in the Ocular Hypertensive Treatment Study(OHTS) randomized at Mayo Clinic to medication or observation were evaluated with specular microscopy annually for 6 years. Confocal microscopy was performed 78 to 108 months after enrollment. Subbasal nerve density was calculated by manual tracing and digital image analysis. Keratocyte density was determined by manual counting methods. Data were compared using a t test and a rank sum test.Results: After 6 years, corneal endothelial cell density, percent hexagonal cells, and coefficient of variation of cell area for the observation (n = 21) and medication groups (n = 26) were similar (2415 6 300 vs. 2331 6 239 cells/mm 2 ; 63% 6 11% vs. 65% 6 10%; and 0.32 6 0.07 vs. 0.30 6 0.06, respectively). Of 38 participants undergoing confocal examination, the medication group (n = 19) had fewer nerves (3.8 6 2.1 vs. 5.9 6 2.0 nerves/frame; P = 0.02) and a lower nerve density (5643 6 2861 vs. 9314 6 3743 mm/mm 2 ; P = 0.007) than the observation patients (n = 10). An additional 9 patients in the observation group, who began medication before confocal scanning, had intermediate nerve densities. Fullthickness keratocyte density was similar, with 22,257 6 2419 and 23,430 6 3285 cell/mm 3 in the observation and medication groups, respectively.Conclusions: Chronic administration of glaucoma medications causes a decrease in the number and density of corneal subbasal nerve fiber bundles but does not affect keratocyte density or corneal endothelial characteristics.

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Section: Discussionmentioning

confidence: 81%

Effects of Glaucoma Medications on Corneal Endothelium, Keratocytes, and Subbasal Nerves Among Participants in the Ocular Hypertension Treatment Study

Baratz

Nau

Winter

et al. 2006

Cornea

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“…Nos grupos com glaucoma primário de ângulo aberto e glaucoma primário de fechamento angular, a maioria dos pacientes usava de um a três colírios hipotensores oculares, no momento da paquimetria. No entanto, de acordo com a literatura pesquisada, não consideramos que este fato possa ter influenciado no resultado final (23,(25)(26) .…”

Section: Discussionunclassified

Correlação entre a espessura corneana central e o comprimento axial ocular nos portadores de glaucoma e em olhos normais

Mello¹,

Meirelles²,

Júnior³

2009

Arq. Bras. Oftalmol.

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“…Both histological changes of collagen (due to an upregulation of matrix metalloproteinases) and modification of the corneal endothelial pump function have been reported after the administration of topical antiglaucoma therapy. 37,38 Drug-induced changes of corneal structural properties, such as hydration and rigidity, could explain the different ability of DCT compared to GAT to measure IOP in glaucomatous compared to healthy eyes. This observation requires further confirmation in healthy eyes subjected to manometry.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Goldmann applanation tonometry and dynamic contour tonometry in healthy and glaucomatous eyes

Ceruti

Morbio

Marraffa

et al. 2008

Eye

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Purpose To compare the measurements of intraocular pressure (IOP) with dynamic contour tonometry (DCT) and Goldmann applanation tonometry (GAT) in healthy and glaucomatous eyes and to evaluate the influence of corneal thickness (CCT), corneal curvature (CC), axial length (AL), and age on these tonometric alternatives. Methods Three hundred eyes of 100 healthy subjects, 100 patients with primary open angle glaucoma, and 100 patients with primary angle-closure glaucoma underwent IOP evaluation with DCT and GAT, and measurements of CCT, CC, and AL. Bland-Altman plots were used to evaluate the agreement between tonometers. Regression analysis was used to evaluate the influence of ocular structural factors on IOP measurements obtained with both tonometers. Results Bland-Altman plots indicated that the 95% limits of agreement between tonometers were À1.4 to 6.6 mmHg. DCT values measured 2.6 ± 1.9 mmHg higher than GAT readings (Po0.001). The mean IOP difference between DCT and GAT (DIOP) was higher in healthy than in glaucomatous eyes and the magnitude of difference increased with increasing CCT. A significant reduction of DIOP with an increase in both CCT (Po0.001) and IOP values (Po0.001) was found. Regression analysis showed no effect of CC, AL, and age on both DCT and GAT readings. In contrast to GAT (Po0.001), DCT measurements were not influenced by CCT (P ¼ 0.43).Conclusions IOP readings obtained by DCT were higher and less affected by CCT than those by GAT. The DIOP was higher in healthy than in glaucomatous eyes and decreased in relation to increased CCT and IOP values.

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Influence of dorzolamide on corneal thickness, endothelial cell count and corneal sensibility

Abstract: ABSTRACT. Purpose: Dorzolamide (Trusopt

Cited by 59 publications

References 7 publications

Effects of Glaucoma Medications on Corneal Endothelium, Keratocytes, and Subbasal Nerves Among Participants in the Ocular Hypertension Treatment Study

Effects of Glaucoma Medications on Corneal Endothelium, Keratocytes, and Subbasal Nerves Among Participants in the Ocular Hypertension Treatment Study

Correlação entre a espessura corneana central e o comprimento axial ocular nos portadores de glaucoma e em olhos normais

Comparison of Goldmann applanation tonometry and dynamic contour tonometry in healthy and glaucomatous eyes

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