Influence of donor–recipient gender mismatch on graft function and survival following lung transplantation†

Abstract

Donor-recipient gender mismatch does not have a negative impact on early graft function and mortality following lung transplantation. There is a trend towards a survival benefit for female recipients, irrespective of the donor gender.

Gender differences in long‐term survival post‐transplant: A single‐institution analysis in the lung allocation score era

“…In female recipients of a heart transplant or a lung transplant, a survival advantage over male recipients has been noted (although that advantage is largely accounted for by the negative influence of female‐to‐male mismatches) . In the field of lung transplantation, several, but not all, authors have observed a survival advantage for female recipients . As noted above, Gries and colleagues—in their review of a large ISHLT registry of 18 072 patients, mostly in the pre‐LAS era—found no overall gender differences in survival .…”

Lung transplantation and gender effects on survival of recipients with cystic fibrosis

“…In fact, lack of significant effect of donor-recipient gender mismatch has also been observed in several other studies. [14,24,25] However, these studies did not limit the analysis to CF patients nor do a sub-analysis of those with CF. In general, in most of these studies, CF patients constituted approximately 15% of the study population.…”

Donor–Recipient Size Matching and Survival after Lung Transplantation. A Cohort Study

“…However, sex affects lung size independent of height (4,5,7). Furthermore, in a study in which donor lungs were allocated for transplantation via a mechanism of acceptable pTLC ratios rather than acceptable height ranges, sex did not predict survival (31,32). Worse survival in the setting of a female donor-to-male recipient sex mismatch has been reported in several studies (2,3).…”