Influence of Disease Severity and Gender on HLA-C Methylation in COVID-19 Patients

Sharif-zak, Mohsen; Abbasi-Jorjandi, Mojtaba; Asadikaram, Gholamreza; Ghoreshi, Zohreh-al-sadat; Rezazadeh-Jabalbarzi, Mitra; Rashidinejad, Hamidreza

doi:10.1007/s40995-022-01334-1

Cited by 2 publications

(1 citation statement)

References 52 publications

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“…For example, differential expression of methylation-sensitive genes, such as type I interferon genes, angiotensin-converting enzyme 2 (ACE2), and IL6, predisposes patients' antiviral responses to be exaggerated [71,72]. A higher rate of HLA-C methylation in severe COVID-19 patients was identified compared to moderately ill patients, corroborating the GWAS described above [73]. Additionally, epigenetic alterations in hypoxia-inducible factor 1 (HIF-1) signaling, Toll-like receptor signaling (TLR), fatty acid oxidation/degradation, autophagy, retinoic acid-inducible gene I (RIG-I) signaling, and demethylation of IL17 signaling genes may predispose certain patients to fatal outcomes [74].…”

Section: Host Epigenomicssupporting

confidence: 70%

COVID-19-Omics Report: From Individual Omics Approaches to Precision Medicine

Vlasova-St. Louis,

Fang,

Amer

et al. 2023

Reports

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During the COVID-19 pandemic, it became apparent that precision medicine relies heavily on biological multi-omics discoveries. High throughput omics technologies, such as host genomics, transcriptomics, proteomics, epigenomics, metabolomics/lipidomics, and microbiomics, have become an integral part of precision diagnostics. The large number of data generated by omics technologies allows for the identification of vulnerable demographic populations that are susceptible to poor disease outcomes. Additionally, these data help to pinpoint the omics-based biomarkers that are currently driving advancements in precision and preventive medicine, such as early diagnosis and disease prognosis, individualized treatments, and vaccination. This report summarizes COVID-19-omic studies, highlights the results of completed and ongoing omics investigations in individuals who have experienced severe disease outcomes, and examines the impact that repurposed/novel antiviral drugs, targeted immunotherapeutics, and vaccines have had on individual and public health.

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Section: Host Epigenomicssupporting

confidence: 70%

COVID-19-Omics Report: From Individual Omics Approaches to Precision Medicine

Vlasova-St. Louis,

Fang,

Amer

et al. 2023

Reports

View full text Add to dashboard Cite

show abstract

The immunogenetics of COVID-19

Hollenbach

Srivastava

2022

Immunogenetics

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The worldwide coronavirus disease 2019 pandemic was sparked by the severe acute respiratory syndrome caused by coronavirus 2 (SARS-CoV-2) that first surfaced in December 2019 (COVID-19). The effects of COVID-19 differ substantially not just between patients individually but also between populations with different ancestries. In humans, the human leukocyte antigen (HLA) system coordinates immune regulation. Since HLA molecules are a major component of antigen-presenting pathway, they play an important role in determining susceptibility to infectious disease. It is likely that differential susceptibility to SARS-CoV-2 infection and/or disease course in COVID-19 in different individuals could be influenced by the variations in the HLA genes which are associated with various immune responses to SARS-CoV-2. A growing number of studies have identified a connection between HLA variation and diverse COVID-19 outcomes. Here, we review research investigating the impact of HLA on individual responses to SARS-CoV-2 infection and/or progression, also discussing the significance of MHC-related immunological patterns and its use in vaccine design.

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Influence of Disease Severity and Gender on HLA-C Methylation in COVID-19 Patients

Cited by 2 publications

References 52 publications

COVID-19-Omics Report: From Individual Omics Approaches to Precision Medicine

COVID-19-Omics Report: From Individual Omics Approaches to Precision Medicine

The immunogenetics of COVID-19

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