Influence of Dietary Polyphenols on Carbohydrate Metabolism

Tan, Benny Kwong Huat; Ong, Khang Wei

doi:10.1016/b978-0-12-398456-2.00009-8

Cited by 10 publications

(8 citation statements)

References 203 publications

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“…One of the primary targets for the management of early stage T2DM is to maintain steady blood glucose levels and prevent the postprandial surge of glucose, and an effective way of achieving this is by inhibiting α-amylase or α-glucosidase [ 7 ]. In our study, α-amylase and α-glucosidase inhibitory potential of liquid nutritional supplements were compared with a positive control (acarbose).…”

Section: Resultsmentioning

confidence: 99%

“…Salivary and pancreatic α-amylase and intestinal α-glucosidase are responsible for the digestion and absorption of glucose from the diet. By inhibiting either of these enzymes the amount of glucose absorbed into the blood following a meal can be reduced, thus preventing the postprandial surge in glucose and maintaining glucose homeostasis [ 6 , 7 ]. Acarbose, a synthetic drug and a known α-glucosidase and α-amylase inhibitor, is currently prescribed to type 2 diabetic patients.…”

Section: Introductionmentioning

confidence: 99%

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Nutritional supplements modulate fluorescent protein-bound advanced glycation endproducts and digestive enzymes related to type 2 diabetes mellitus

Koch

Deo

2016

BMC Complement Altern Med

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BackgroundChronic hyperglycemia enhances the formation of advanced glycation endproducts (AGEs) and reactive oxygen species (ROS), contributing to diabetic complications. Thus, controlling blood glucose levels, inhibiting the formation of AGEs and reducing ROS are key therapeutic targets in early stage type 2 diabetes.MethodsThe inhibitory effects of seven commercial liquid nutritional supplements against carbohydrate hydrolysing enzymes, α-amylase and α-glucosidase, was determined by dinitrosalicylic (DNS) reagent and p-nitrophenyl-α-D-glucopyranoside solution, respectively. Antiglycation activity was determined using the formation of fluorescent protein-bound AGEs. Total phenolic and flavonoid content and antioxidant properties (1,1-diphenyl-2-picrylhydrazyl antioxidant activity (DPPH) and ferric reducing antioxidant power (FRAP)) were determined for correlation among these components and inhibitory activities.ResultsSamoan noni juice showed the greatest inhibitory effects against α-amylase, whereas chlorophyll extracts showed the greatest inhibitory effect against α-glucosidase. Inhibition of α-glucosidase correlated with TFC (r2 = 0.766; p < 0.01) and FRAP (r2 = 0.750; p < 0.01) whereas no correlation was observed for α-amylase inhibition. All supplements inhibited fluorescent protein-bound AGEs, with the greatest effect exerted by Olive Leaf Extract, Blood Sugar Support (IC50 = 0.5 mg/ml). The IC50 values negatively correlated with TPC (r2 = −0.707; p < 0.001) and DPPH scavenging activities (r2 = 0.515; p < 0.05).ConclusionThe findings of this study highlight the potential of liquid nutritional supplements in managing and treating type 2 diabetes mellitus.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Nutritional supplements modulate fluorescent protein-bound advanced glycation endproducts and digestive enzymes related to type 2 diabetes mellitus

Koch

Deo

2016

BMC Complement Altern Med

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“…Salah satu mekanisme fenol dan flavonoid dalam menurunkan kadar GDP adalah dengan menghambat α-amilase dan α-glukosidase (Tan & Ong, 2014;Unnikrishnan et al, 2014). Enzim αamilase saliva dan pankreas yang akan berfungsi untuk menghidrolisis pati menjadi disakarida, kemudian disakarida akan dihidrolisis oleh α-glukosidase menjadi glukosa agar dapat diabsorpsi oleh mukosa usus halus (Tan & Ong, 2014). Kandungan antioksidan lainnya yang terdapat pada TTU adalah antosianin.…”

Section: Kadar Glukosa Darah Puasaunclassified

Potensi Antidiabetik Tepung Terung Ungu (Solanum Melongena L.) pada Tikus Hiperglikemia

Fajriana

2022

JKM

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Diabetes Mellitus (DM) is a group of metabolic diseases characterized and identified with hyperglycemia due to impaired insulin secretion, insulin action, or both, and the presence of impaired metabolism of carbohydrates, fats, and proteins. IDF data shows the prevalence is increasing from year to year, namely 9.3% (2020) and 10.5% (2021). Treatment of DM was needed a combination of pharmacological and non-pharmacological treatment by utilizing local foods in the diet. Purple eggplant (Solanum melongena L.) is one of the potential plants in Indonesia that is very rich in antioxidants and believed to decrease fasting blood glucose (FBG) levels. The study aimed to determine the effect of purple eggplant flour (TTU) on the weight and fasting blood glucose levels of hyperglycemia rats. This true experimental study design used a pre-post test with a control group design. Thirty-six male Sprague Dawley rats were divided randomly into five groups: KN group (7 rats), KD (8 rats), P1 (7 rats), P2 (7 rats), and P3 (7 rats). The rats used were 10-12 weeks, weighing 207.25±26.76 grams. The hyperglycemia rat model was made by induced NA (230 mg/kg body weight)-STZ (65 mg/kg body weight) intraperitoneally. Intervention in the form of TTU modified feed (standard feed is substituted with TTU according to the dose) was given for 28 days with dose variations of 2.36 grams, 4.71 grams, and 7.07 grams. Body weight and FBG level were measured before and after the intervention. Data were analyzed statistically using One Way Anova test, Bonferroni test, and uji paired t-test. The body weight of DM rats was significantly lower, and FBG levels were significantly higher than normal rats (KN). Orally administration of TTU for 28 days significantly increased body weight (6.59%-19.54%) and reduced levels of FBG (33.04-54.61%). The changes in FBG levels were in line with the increasing doses of intervention. Purple eggplant flour was able to maintain body weight and reduce the levels of FGB hyperglycemia in rats induced by NA-STZ.

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“…Insulin and glucagon have a major regulatory role in the activity of these processes. In the periods when the nutrients do not enter the body, all the glucose coming into the circulation is delivered by the liver [129]. Upon food intake, increased glucose levels stimulate secretion of insulin, which has an inhibitory effect on hepatic mechanisms delivering free glucose.…”

Section: Effects On Glucose Homeostasis In the Livermentioning

confidence: 99%

Antidiabetic Potential of Plants Used in Bulgarian Folk Medicine and Traditional Diet

Nashar¹,

Kiselova-Kaneva²,

Ivanova³

2019

Nutrition in Health and Disease - Our Challenges Now and Forthcoming Time

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The idea of this chapter is that currently available antidiabetic drugs specifically target several points of the T2D pathophysiology but they do not cover all aspects of the disease. In addition, many adverse effects of synthetic antidiabetic agents have been reported. The suggested manuscript is an overview of the available scientific literature focused on antiobesity and antidiabetic potential of selected 42 medicinal and edible plants of the Bulgarian flora. Most of the reports reveal the effect of extracts or their active components on specific biochemical mechanisms. Mechanistic data about hypoglycemic and hypolipidemic action are presented for some of the plants. An essential part of this review is dedicated to the target mechanisms behind the effects of the selected plant species. The authors hope that this review will serve as a starting point for future investigations with a contribution to the prevention and therapy of diabetes.

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Influence of Dietary Polyphenols on Carbohydrate Metabolism

Cited by 10 publications

References 203 publications

Nutritional supplements modulate fluorescent protein-bound advanced glycation endproducts and digestive enzymes related to type 2 diabetes mellitus

Nutritional supplements modulate fluorescent protein-bound advanced glycation endproducts and digestive enzymes related to type 2 diabetes mellitus

Potensi Antidiabetik Tepung Terung Ungu (Solanum Melongena L.) pada Tikus Hiperglikemia

Antidiabetic Potential of Plants Used in Bulgarian Folk Medicine and Traditional Diet

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