Influence of dicephalic ionic surfactant interactions with oppositely charged polyelectrolyte upon the in vitro dye release from oil core nanocapsules

Microfluidic platform for photodynamic therapy cytotoxicity analysis of nanoencapsulated indocyanine-type photosensitizers

“…Surfactant: N,N-bis[3,3 0 (trimethylammonio)-propyl]dodecanamide dimethylsulfate (C 12 (TAPAMS) 2 ) was synthesized according to the method described in previously. 35 Water used for all experiments was distilled and purified by using of a Millipore (Bedford, MA) Milli-Q purification system.…”

“…The surface charge was determined by f-potential measurements and as it has been proved in our previous studies, the stable nanostructures were obtained when the zeta potential of nanocarriers with the adsorbed PE layer was close to the zeta potential of the same polycation or polyanion in solution. 34,35 Consequently, the volumes of polyelectrolyte solution used to form each layer of nanocapsules shell were determined experimentally by the evaluation of the results of simultaneous zeta potential measurements. The results of f-potential measurements during the LbL deposition are typical zigzag dependence used as evidence for the formation of consecutive layers and stability of the obtained nanocapsules.…”

“…It also allows improving drug's efficacy, its stability, and better intracellular penetration, owing to their enhanced permeation, specific cell targeting, and long circulation in blood stream. [31][32][33][34][35] We have selected a NIR heptamethine indocyanine dye (i.e., IR-780 iodide) as a model hydrophobic photosensitizer basing mainly upon its excellent optical properties and good photosensitizing attributes. IR-780 indocyanine due to its characteristic excitation (k exc.…”

Relationship between Partition Coefficients of Carboxylic Acids and Changes in Osmotic Resistance in Rat Erythrocytes In vitro

“…The concentrations of each substance required to permeate the lipid layer induce solubilization of the membrane is defined as the critical micellar concentration (CMC) and is measured by various physicochemical methods [9][10][11]. Hemolysis induced by solubilization of membrane usually occurs above the CMC, and surfactants with a low CMC are more hemolytic [12][13][14][15].…”

Synthesis, surface activity and antielectrostatic properties of new soft dichain cationic surfactants

“…Studies on interfacial properties of cationic surfactants are very important for many practical applications related to their solubilization ability, adsorption and aggregation properties, improvement of wetting and antimicrobial activity against bacteria, yeasts and molds [2,7,9,[11][12][13][14]. Nowadays, functionalized cationic surfactants are also used as protective materials on the surfaces of solids, lubricants, antistatic agents and fabric softeners because they adsorb onto textiles due to their negative-charged surfaces in water [10,11].A c c e p t e d M a n u s c r i p t As a continuation of our studies on new functionalized cationic surfactants and their properties [15][16][17][18], herein we describe synthetic methodology, surface activity and antielectrostatic properties, regarding the structure-performance relationships, of two homologous series of new soft cationic surfactants, diesterquat-type N, N-dimethyl-N,N-bis[2-(alkyloxycarbonyl)ethyl]ammonium bromides (2xC n E-Br, n = 10, 12) and diamidequat-type N, N-dimethyl-N,N-bis[2-(N-alkylcarbamoyl)ethyl]ammonium bromides (2xC n A-Br, n = 8, 10, 12) surfactants (all structures and the applied synthetic route are shown in Scheme 1).Common characteristics of obtained series of compounds is the presence of labile linkers -ester -COOR or amide -CONHR moieties -between the alkyl tails and the hydrophilic quaternary ammonium group. Both groups are vulnerable to hydrolytic degradation in acidic and basic aqueous media.…”