Influence of depression in mild Parkinson's disease on longitudinal motor and cognitive function

Precuneal Thickness and Depression in Parkinson Disease

“…Depression represents the most common psychiatric feature of PD [1] affecting from 17 to 22% of patients from the premotor until the advanced phases [2,3,4], leading to a worse quality of life [2]. In addition, depression in the early stages of PD may represent a risk factor for a more pronounced motor and cognitive decline [5]. …”

The effects of lifelong cognitive lifestyle on executive function in older people with Parkinson's disease

“…Executive function particularly relates to efficiency of fronto‐parietal‐striatal (Gawrys et al, ) degeneration, which may in part be a function of age (Mufson et al, ). In PD, executive function may also be affected by deterioration in cholinergic subcortical white matter (Shin et al, ), the severity of motor function and depression and by the L‐dopa dosage (Ng et al, ) (Tables ).…”

Prevalence of depression and receipt of antidepressant pharmacotherapy among patients with Parkinson’s disease: a national assessment of US office-based physician visits

“…3 This finding suggests that depression may be detected in less than one-half of symptomatic patients. 3 Untreated and undertreated depression in PD can lead to worsening motor function, 8,9 hastened cognitive decline, 8,10 decreased quality of life, 11 and increased mortality. 12 In addition, nonmotor features of PD, such as depression, may lead to significant disability despite improvement in motor symptoms.…”

“…13 Thus, it is essential that symptoms of depression be promptly recognized and adequately addressed to prevent an expedited course of PD deterioration, in an effort to improve quality of life of patients and caregivers. 8,11 Depression in patients with PD is often treated with antidepressants, usually selective serotonin reuptake inhibitors (SSRIs) because of their favorable side effect profile in the elderly.…”