Influence of Deflufenican Herbicide on the Chemical Composition of Essential Oil Elsholtzia Ciliata (Thunb.) Hyl

Байбеков, Р Ф; Dmitrieva, V.L.; Белопухов, С Л; Dmitriev, L. B.; Suchkova, L.O

doi:10.29296/25877313-2020-04-01

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The composition of this essential oil was similar to that reported by other groups [ 6 , 7 , 8 ], with the main component dehydroelsholtsia ketone, which was first isolated from this source in 1997, and for which a structure of 3-methyl-2-(3-methylbut-2-enoyl)furan was suggested [ 9 ]. Chemical composition of E. ciliata herb could vary because of environmental factors and different growing places [ 10 ]. Furthermore, an anticancer activity of the E. ciliata on human glioblastoma (U87), pancreatic cancer (Panc-1) and triple negative breast cancer (MDA-MB231) cell lines has been demonstrated in vitro [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Antiarrhythmic Properties of Elsholtzia ciliata Essential Oil on Electrical Activity of the Isolated Rabbit Heart and Preferential Inhibition of Sodium Conductance

et al. 2020

View full text Add to dashboard Cite

Elsholtzia ciliata essential oil (E. ciliata) has been developed in Lithuania and internationally patented as exerting antiarrhythmic properties. Here we demonstrate the pharmacological effects of this herbal preparation on cardiac electrical activity. We used cardiac surface ECG and a combination of microelectrode and optical mapping techniques to track the action potentials (APs) in the Langendorff-perfused rabbit heart model during atrial/endo-/epi-cardial pacing. Activation time, conduction velocity and AP duration (APD) maps were constructed. E. ciliata increased the QRS duration and shortened QT interval of ECG at concentrations of 0.01–0.1 μL/mL, whereas 0.3 μL/mL (0.03%) concentration resulted in marked strengthening of changes. In addition, the E. ciliata in a concentration dependent manner reduced the AP upstroke dV/dtmax and AP amplitude as well as APD. A marked attenuation of the AP dV/dtmax and a slowing spread of electrical signals suggest the impaired functioning of Na+-channels, and the effect was use-dependent. Importantly, all these changes were at least partially reversible. Our results indicate that E. ciliata modulates cardiac electrical activity preferentially inhibiting Na+ conductance, which may contribute to its effects as a natural antiarrhythmic medicine.

show abstract