Influence of Cyclandelate on In Vitro Red Blood Cell Deformability

Hall, Daniel; Hoven, W. E. van den

doi:10.2165/00003495-198700332-00008

Cited by 5 publications

(1 citation statement)

References 13 publications

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“…Acetyl L‐carnitine has shown some benefit in a single blind trial[212]. Cyclandelate, which can alter some rheological abnormalities[213], did not lead to an improvement in pain in a small subset of patients with symptomatic neuropathy[214]. Anecdotal reports suggested that pentoxifylline, which could also potentially alter microvascular perfusion, may help in pain reduction[215].…”

Section: Other Trialsmentioning

confidence: 99%

Painful diabetic neuropathy

1999

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Summary Chronic painful diabetic neuropathy causes symptoms that can last for many years and severely impair the quality of life of affected patients. This review describes the epidemiology, pathophysiology and treatment of chronic neuropathic pain. Particular emphasis is placed on a comprehensive review of the management of painful symptoms through a detailed review of the published literature using a variety of databases particularly Medline and EMBASE.

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Section: Other Trialsmentioning

confidence: 99%

Painful diabetic neuropathy

1999

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Wirkungen von Cyclandelat auf das ZNS — Eine doppelblinde, placebo-kontrollierte Studie an gesunden Probanden

et al. 1991

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The effect of cyclandelate (Natil) on the CNS was tested in a double-blind, placebo-controlled pilot study on 48 healthy males using a single oral dosage of 1200 mg. The EEG was evaluated quantitatively by spectral analysis before and one hour as well as two and a half hours after drug or placebo administration under resting conditions and while performing a test of mental arithmetic. Under resting conditions the power in the alpha 2 frequency band of the signals from the frontal and central recordings was increased in the cyclandelate group in comparison to the placebo group. This effect was still observed two and a half hours after drug intake. Under the condition of mental arithmetic no drug related effect was observed in the EEG. The cyclandelate induced increase of spectral power in the alpha 2 frequency band under resting conditions demonstrates a general effect of cyclandelate on the CNS. The results are discussed with respect to the known age related decrease of spectral power in the alpha frequency band. The established effect of cyclandelate in young healthy subjects calls for a study with chronic treatment in elderly subjects or patients with cognitive deficits.

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