Influence of Curcumin (<i>Curcuma Longa</i>) as a Natural Anticoccidial Alternative in Adult Rabbits: First Results

Cervantes-Valencia, María Eugenia; Alcalá-Canto, Yazmín; Salem, Abdelfattah Z.M.; Kholif, Ahmed E.; Ducoing-Watty, Adriana Margarita; Bernad‐Bernad, María Josefa; Gutiérrez-Olvera, Carlos

doi:10.4081/ijas.2015.3838

Cited by 20 publications

(23 citation statements)

References 22 publications

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“…Curcumin is a polyphenol from C. longa rhizome with antioxidant and antiparasitic effects. As such, Eimeria- infected animals showed diminished oocysts shedding and less lesions after curcumin treatment (19, 27, 40, 41). More importantly, daily weight gains revealed two-fold higher in curcumin-treated farm animals compared to non-treated controls (28).…”

Section: Discussionmentioning

confidence: 90%

“…Therefore, in vitro anti-protozoan effects of curcumin against numerous species have recently been described, i.e., Eimeria tenella, E. bovis, Giardia intestinalis, Plasmodium falciparum, P. berghei, Leishmania spp., Trypanosoma cruzi, T. evansi, Cryptosporidium parvum, Neospora caninum , and Toxoplasma gondii (19–26). In addition, in vivo effects of curcumin treatments were also documented in rabbit and sheep coccidiosis (27, 28). Overall, the molecular mechanism of curcumin action is not known so far, but interference with intracellular organelles and cytoskeleton or with cellular metabolism is postulated (29), which might impact on protozoan parasites.…”

Section: Introductionmentioning

confidence: 99%

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Antiparasitic Efficacy of Curcumin Against Besnoitia besnoiti Tachyzoites in vitro

et al. 2019

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Besnoitia besnoiti is the causative agent of bovine besnoitiosis. B. besnoiti infections lead to reduced fertility and productivity in cattle causing high economic losses, not only in Europe, but also in Asia and Africa. Mild to severe clinical signs, such as anasarca, oedema, orchitis, hyperkeratosis, and characteristic skin and mucosal cysts, are due to B. besnoiti tachyzoite and bradyzoite replication in intermediate host tissues. So far, there are no commercially available effective drugs against this parasite. Curcumin, a polyphenolic compound from Curcuma longa rhizome is well-known for its antioxidant, anti-inflammatory, immunomodulatory and also anti-protozoan effects. Hence, the objective of this study was to evaluate the effects of curcumin on viability, motility, invasive capacity, and proliferation of B. besnoiti tachyzoites replicating in primary bovine umbilical vein endothelial cells (BUVEC) in vitro. Functional inhibition assays revealed that curcumin treatments reduce tachyzoite viability and induce lethal effects in up to 57% of tachyzoites (IC50 in 5.93 μM). Referring to general motility, significant dose-dependent effects of curcumin treatments were observed. Interestingly, curcumin treatments only dampened helical gliding and twirling activities whilst longitudinal gliding motility was not significantly affected. In addition, curcumin pretreatments of tachyzoites resulted in a dose-dependent reduction of host cell invasion as detected by infections rates at 1 day p. i. These findings demonstrate feeding cattle with Curcuma longa rhizomes may represent a new strategy for besnoitiosis treatment.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Antiparasitic Efficacy of Curcumin Against Besnoitia besnoiti Tachyzoites in vitro

et al. 2019

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“…Curcumin secara luas telah dipakai sebagai anti oksidan, anti radang dan secara in vitro berkasiat sebagai anti tumor (Hatcher et al, 2008), anti coccidia (Cervantes-Valencia et al, 2015), meningkatkan performa ayam petelur (Frita et al, 2016), mastitis, luka dan bengkak pada leher, pendarahan pada tanduk (Phondani et al, 2010 ). Herbal ke dua yang banyak dipakai (15 peternak) adalah pinang sebagai obat cacing.…”

Section: Hasil Dan Pembahasanunclassified

Survey Pemanfaatan Medicinal Herbs untuk Peningkatan Produktivitas dan Kesehatan Ternak Ruminansia di Bengkulu

Suteky

Dwatmadji

Edi

2020

Jurnal Sain Peternakan Indonesia

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Penelitian ini bertujuan untuk mendokumentasikan tanaman obat lokal yang dipergunakan untuk peningkatan produktivitas dan kesehatan ternak ruminansia di Bengkulu. Data diperoleh melalui wawancara terhadap 75 petani di Bengkulu, semi stuktur quisioner dipergunakan sebagai pedoman untuk bertanya seperti nama tanaman yang dipergunakan, bagian yang dimanfaatkan, cara penggunaannya, dan termasuk bahan lain yang ditambahkan. Setiap tumbuhan yang disebut oleh responden dicatat nama lokal untuk identifikasi nama ilmiahnya. Pada penelitian ini studi literatur dipergunakan untuk mengetahui nama ilmiah/latin dan untuk mengetahui kandungan fitokimianya. Data dianalisis secara deskripstif. Hasil penelitian menunjukkan tercatat ada 33 medicinal herbs yang dipakai oleh petani peternak, tanaman tersebut masuk dalam 16 genus dan 14 famili. Medicinal herbs dari famili Zingiberaceae yang terdiri dari 7 species merupakan tanaman yang paling banyak dimanfaatkan, sedangkan 13 famili yang lain diwakili 1 species setiap familinya. Curcuma longa Linn dan Curcuma domestica merupakan medicinal herbs yang paling banyak dipergunakan untuk meningkatkan nafsu makan, mencegah penyakit, bloat, infestasi parasit internal, dan luka. Pemberian tanaman obat secara per oral merupakan metode yang paling banyak dipergunakan diikuti dengan cara topikal. Nama ilmiah dan komponen fitokimia dipelajari berdasarkan studi literatur. Medicinal herbs yang dipergunakan oleh petani peternak kebanyakan merupakan kitchen herbs dengan demikian tanaman ini relatif aman untuk ternak ruminansia.

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“…Moreover, chemical treatments are costly when used regularly to prevent helminth parasites in livestock (Jabbar et al 2006). Consequently, there is an increasing interest in screening phytogenic extracts and medicinal plants as alternatives to the expensive traditional drugs (Olmedo-Juárez et al 2014;Cedillo et al 2015;Cervantes-Valencia et al 2015). It has been reported that medicinal plants not only possess anthelmintic activity, but also have antibacterial and insecticidal properties (Mejía-Hernández et al 2014).…”

Section: Introductionmentioning

confidence: 99%

“…It has been reported that medicinal plants not only possess anthelmintic activity, but also have antibacterial and insecticidal properties (Mejía-Hernández et al 2014). The use of naturally produced plants with anthelmintic properties can also reduce the cost of importing drugs and therefore boost the economic self-reliance in developing countries (Mejía-Hernández et al 2014;Cedillo et al 2015;Cervantes-Valencia et al 2015).…”

Section: Introductionmentioning

confidence: 99%

Tree leaves of Salix babylonica extract as a natural anthelmintic for small-ruminant farms in a semiarid region in Mexico

et al. 2016

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Influence of Curcumin (Curcuma Longa) as a Natural Anticoccidial Alternative in Adult Rabbits: First Results

Cited by 20 publications

References 22 publications

Antiparasitic Efficacy of Curcumin Against Besnoitia besnoiti Tachyzoites in vitro

Antiparasitic Efficacy of Curcumin Against Besnoitia besnoiti Tachyzoites in vitro

Survey Pemanfaatan Medicinal Herbs untuk Peningkatan Produktivitas dan Kesehatan Ternak Ruminansia di Bengkulu

Tree leaves of Salix babylonica extract as a natural anthelmintic for small-ruminant farms in a semiarid region in Mexico

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