Influence of crystallinity and fiber orientation on hydrophobicity and biological response of poly(l-lactide) electrospun mats

Abstract

Royal Society of ChemistryAreias, A.; Ribeiro, C.; Sencadas, V.; Garcia Giralt, N.; Diez Perez, A.; Gómez Ribelles, JL.; Lanceros Mendez, S. (2012). Influence of crystallinity and fiber orientation on hydrophobicity and biological response of poly(L-lactide) electrospun mats. Soft Matter. 8 (21) AbstractPoly(L-lactide) electrospun mates have been produced with random and aligned fiber orientation and degrees of crystallinity from 0 up to nearly 50%. These two factors, fiber alignment and degree of crystallinity strongly affect the hydrophobicity of the samples, being this larger for the aligned fiber mats and for the fibers with higher degree of crystallinity. Whereas the first effect can be associated to a decrease in the degree of porosity the second should be related to variations in the fiber roughness at nanometric scale and an increase in fiber stiffness. Proliferation of human chondrocytes cultured in monolayer on these substrates is similar in both aligned and non-aligned amorphous mats. Crystallization of the aligned mats, on the other hand, nearly suppresses proliferation and the cells produce higher amounts of aggrecan, characteristic of the extracellular matrix of hyaline cartilage.

Effect of filler content on morphology and physical–chemical characteristics of poly(vinylidene fluoride)/NaY zeolite-filled membranes

“…Finally, oriented samples without and with 16 %wt NaY content revealed an increase of the water contact angle up to 133 ± 5º and 137± 6º, respectively, which is slightly higher than the one found for the randomly oriented fibers. These results support the idea that the increase of the hydrophobic behavior of the electrospun samples is mainly related to the changes in membrane overall roughness [29]. The same is shown by the PVDF films (PF), which hydrophilicity increases with increasing zeolite content, but the contact angle values are still much lower than for the fiber composites.…”

“…One of the most efficient ways to increase the surface area of composites consists on the production of microfibers by electrospinning [22], in which the modification of the processing parameters lead to variations in electrospun fiber morphology, orientation and diameter [23]. In this way, electrospinning can produce fibers and membranes that are able to mimic extracellular matrix (ECM) of biological tissues [24], being increasingly important in the development of scaffolds for a variety of biomedical applications [25,26] by allowing tailoring cell functions, adhesion and proliferation [27] through modulation of surface electrostatic charge [28], wettability [29], mechanical properties [30] and topography. The introduction of fillers in fibers can also contribute to modify bioactivity and even biocompatibility suppression can occur.…”

Greener Synthesis of Nano Hydroxyapatite using Fatty acids template for the application of Tissue Engineering Nano Hydroxyapatite: Fatty acids Synthesis and Characterizations

“…For all the XRD patterns, the representative diffraction peaks of hexagonal Ca10(PO 4 )6(OH) 2 were distinguished, which can be indicated conforming to the standard data of JCPDS No. 09-0432 [21,22]. The corresponding characteristic peaks at 26,32,33,40 attributed to (002), (211), (300), and (310) planes respectively shown in Figure 2c.…”

Electrospinning of Nylon11: Effect of processing parameters on morphology and microstructure

“…MTT assay study shows that cell proliferation rate was higher in Nylon11 electrospun mat, when compared to Nylon11 melt pressed film. We expect that Nylon11 electrospun mat responded better because of 3-D porous structure and higher surface area [55,56]. …”