Influence of Crude Trypsin Inhibitor on Utilization of Hydrolyzed Protein

Westfall, R. J.; Bosshardt, D. K.; Barnes, Richard H.

doi:10.3181/00379727-68-16531

Cited by 32 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This hypothesis was supported by the observation of an increased faecal nitrogen excretion after feeding raw soybeans. However, that inhibition of proteolysis per se could not adequately account for these observations was shown by Klose, Hill, Greaves, and Fevold (1948) and Westfall, Bosshardt, and Barnes (1948) who demonstrated inhibition of growth in animals fed trypsin inhibitor with predigested protein.…”

mentioning

confidence: 99%

A further physiological role for naturally occurring trypsin inhibitors: the evidence for a trophic stimulant of the pancreatic acinar cell

Melmed¹,

Bouchier²

1969

Gut

View full text Add to dashboard Cite

SUMMARY The oral ingestion of naturally occurring purified trypsin inhibitors from soybean, ovomucoid, and bovine pancreas has been demonstrated to be a potent stimulus to pancreatic digestive enzyme synthesis. This effect may be so marked as to lead to impairment of growth in the rat and chicken through the faecal loss of essential amino acids. This is thought to be due to the markedly potentiated secretion of pancreatic digestive enzyme protein overwhelming the normal digestive capacity of the gastrointestinal tract and resulting in a pancreatogenous protein-losing enteropathy.Experimental evidence is presented to suggest that this response to the trypsin inhibitors requires the mediation of the gastrointestinal tract and is independent of vagal innervation to the pancreas. The most satisfactory hypothesis would favour the release of a trophic stimulus from the intestinal mucosa (possibly pancreozymin-cholecystokinin) to the acinar cell of the pancreas in response to the presence of the trypsin inhibitor in the bowel lumen.

show abstract

mentioning

confidence: 99%

A further physiological role for naturally occurring trypsin inhibitors: the evidence for a trophic stimulant of the pancreatic acinar cell

Melmed¹,

Bouchier²

1969

Gut

View full text Add to dashboard Cite

show abstract

“…Doubt was cast upon this logical interpretation when it was shown that a concentrate of the trypsin inhibitor depressed growth when it was added to diets containing predigested proteins (Klose, Greaves & Fevold, 1948;Westfall, Bosshardt & Barnes, 1948).…”

mentioning

confidence: 99%

Trypsin inhibitor and the nutritional value of soya beans

1971

View full text Add to dashboard Cite

1. One reason, based on indirect evidence, advanced in explanation of the low nutritional value of raw soya bean (RS) is that it stimulates the pancreas to secrete massive amounts of protein which are ultimately lost in the faeces. This theory has been investigated directly.2. The expected outpouring of pancreatic protein did not occur when the secretion of enzymes and protein in pancreatic juice from chickens and rats given successively heated soya bean (HS) and RS diets was measured directly.3. It is suggested that RS, acting upon intestinal proteins, forms trypsin inhibitor-protein complexes which, in spite of adequate proteolytic activity, escape digestion and are lost with the faeces, thus decreasing the nutritional value of the diet.

show abstract

Chemoprevention by Nonnutrient Components of Vegetables and Fruits

Birt

Bresnick

1991

Cancer and Nutrition

View full text Add to dashboard Cite

Influence of Crude Trypsin Inhibitor on Utilization of Hydrolyzed Protein

Cited by 32 publications

References 0 publications

A further physiological role for naturally occurring trypsin inhibitors: the evidence for a trophic stimulant of the pancreatic acinar cell

A further physiological role for naturally occurring trypsin inhibitors: the evidence for a trophic stimulant of the pancreatic acinar cell

Trypsin inhibitor and the nutritional value of soya beans

Chemoprevention by Nonnutrient Components of Vegetables and Fruits

Contact Info

Product

Resources

About