The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

An investigation was undertaken to determine the effects of water deprivation during meals in rats. Food intake, gastrointestinal solids water content, rate of digestion and tissue water content were studied. Rats fed without water ate less food than rats fed with water. The gastric contents of all animals fed with or without water was approximately 49% water and indicates close regulation of water in the gastric contents. When fed without water, rats regulate their food intake so that it matches the amount of water that they can mobilize from their own tissues thereby maintaining the proper water:food ratio in the gastric contents. How this is reflected in the mechanisms that control food intake is unknown. The water found in the gastrointestinal contents of rats fed without water is furnished by selected tissues, especially the skin, probably the adipose tissues and perhaps other tissues. The contents of the intestinal lumen contains about 76% of water in all the rats irrespective of the availability of water with meals. The total solids in the intestinal lumen of the rats eating without water averaged 0.39 gm and 0.52 gm for the rats eating with water. The regulation of both water and solids in the intestinal lumen indicates that it acts as though it were a part of the internal environment. Withholding of water during meals does not appear to interfere with digestion but it definitely decreases appetite and effects a reduction of food intake.

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NICOTINIC ACID TREATMENT IN PELLAGRA 405jections with vitaminized or non-vitaminized horse serum. In all cases stimulation of precipitin-production was noted, the contrast being practically identical with those recorded in Fig. 1.In other groups the method of injection was varied by injecting the horse serum and ascorbic acid separately, such as at different times in the same ear vein, or in different veins, or by giving horse serum intravenously and vitamin C intraiibdominally. Stimulation of specific-precipitin production was noted by all of these technics, confirming the conclusions of Burky' and of Swift and Schultz' in their studies of the immuno-"synergic"$ effects of staphylococcal toxin. The antibody-stimulation, however, was less pronounced in these separate injections than those previously obtained by mixing the horse serum and ascorbic acid before injection.The relative efficiency of ascorbic acid and its sodium salt was also compared in small groups of animals. Sodium ascorbate prepared by Sollmann's technic' was found to be but about half as effective as unneutralized ascorbic acid. Sodium ascorbate, however, is apparently unstable, a commercial preparation tested on a small group of rabbits being without demonstrable antibody-stimulating effect.Pellagrins can be cured while on a maize diet by the oral administration of a filtrate of liver which contains the so-called "filtrate factor" but which is free from riboflavin and rat antidermatitis factor.'