Influence of CRP, IL6, and TNFA Gene Polymorphisms on Circulating Levels of C-Reactive Protein in Mexican Adolescents

Mendoza-Carrera, Francisco; Ramírez-López, Guadalupe; Ayala-Martínez, Norma Angélica; Garcı́a-Zapién, Alejandra Guadalupe; Flores-Martínez, Silvia Esperanza; Sánchez‐Corona, José

doi:10.1016/j.arcmed.2010.08.015

Cited by 26 publications

(19 citation statements)

References 34 publications

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“…The genotype frequencies of SNPs rs1130864 and rs3093062 revealed in this study did not differ significantly from those reported in other studies (Kim et al, 2008;Kolz et al, 2008;Almeida et al, 2009;Grammer et al, 2009;Schumacher et al, 2009;Mendoza-Carrera et al, 2010). Differences did arise, however, in the frequencies of SNP rs1130864 found in this study and those from a study conducted in Africa (Israelsson et al, 2009), which may be due to genetic differences between subjects.…”

Section: Discussioncontrasting

confidence: 56%

“…Only one study has reported an association of the polymorphism rs1130864 in the CRP gene with increased serum levels of CRP in adolescents of western Mexico (Guadalajara, Jalisco) with Spanish high genetic component (INAFED, 2005;Mendoza-Carrera et al, 2010). However, these results may vary owing to the genetic diversity of the Mexican population.…”

Section: Introductionmentioning

confidence: 79%

“…This trend was not observed with the rs2794521 SNP. The effects of the SNPs on the variation in CRP levels have been reported in various populations around the world (Kolz et al, 2008;Almeida et al, 2009;Grammer et al, 2009;Schumacher et al, 2009;Teng et al, 2009;Mendoza-Carrera et al, 2010), demonstrating that the effect of CRP SNPs on CRP occurs independent of ethnicity.…”

Section: Discussionmentioning

confidence: 99%

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Common variants in the CRP gene are associated with serum C-reactive protein levels and body mass index in healthy individuals in Mexico

et al. 2012

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ABSTRACT.Variants in the C-reactive protein (CRP) gene have been found to be associated with various phenotypic traits. We evaluated the effect of four SNPs in the CRP gene on serum levels of protein and body mass index (BMI) in 150 unrelated Mexican subjects from 18 to 25 years old, without hypertension, non-overweight, and without inflammatory diseases, non-smoking and non-consumers of alcohol. Subjects were measured for BMI, waist circumference, blood pressure, and serum glucose and triglycerides. The identification of SNPs was ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 11 (3): 2258-2267 (2012) SNPs in the CRP gene associated with CRP levels and BMI 2259performed by PCR-RFLP. Three of the four SNPs were associated with variation in serum levels of CRP, increased in TT (rs1130864) and GG (rs2794521) genotypes, and decreased in the AA genotype of rs1205.The TT genotype was associated with a significant increase in BMI (β = 1.1 kg/m 2 , P = 0.04). Two haplotypes were significantly associated with increased serum levels of CRP, but not with BMI. We conclude that variation in the CRP gene affects serum protein levels.

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Section: Discussioncontrasting

confidence: 56%

Section: Introductionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

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Common variants in the CRP gene are associated with serum C-reactive protein levels and body mass index in healthy individuals in Mexico

et al. 2012

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“…The hsCRP is known to be regulated only in part by TNFa and, therefore, may not be reflective of the inflammatory effects of TNFa, which acts predominately in a paracrine manner. 38,39 Human studies have also shown that TNFa expression is regulated by dietary fatty acids, [40][41][42] and previous studies on the TNFA -308 G4A polymorphism have shown that the relationship between this polymorphism and obesity risk differed depending on dietary fat intake. 1,3 In agreement with this, and to our best knowledge, we are the first to show that with increasing dietary fat intake, irrespective of the type and quality, select measures (weight, BMI, body fat %, fat mass and waist) of body composition increased in black women with the TNFA -238 GA genotype and decreased or did not change in those with the GG genotype ( Figure 1).…”

Section: Discussionmentioning

confidence: 99%

The tumor necrosis factor-α gene -238 G>A polymorphism, dietary fat intake, obesity risk and serum lipid concentrations in black and white South African women

et al. 2012

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BACKGROUND/OBJECTIVES: This study explored interactions between dietary fat intake and the tumor necrosis factor-a gene (TNFA) -238 G4A polymorphism (rs361525) on adiposity and serum lipid concentrations in apparently healthy premenopausal black and white South African (SA) women. SUBJECTS/METHODS: Normal-weight (N ¼ 107) and obese (N ¼ 120) black, and normal-weight (N ¼ 89) and obese (N ¼ 62) white SA women underwent measurements of body composition, fasting lipids and dietary intake, and were genotyped for the -238 G4A polymorphism. RESULTS: Black women had a higher -238 GA genotype frequency than white women (Po0.001), but there were no differences between body mass index groups. Black women with the -238 A allele had a greater body fat % than those with the GG genotype (Po0.001). Further, in black women, with increasing polyunsaturated:saturated fat ratio and omega-6 (n-6):omega-3 (n-3) ratio, high-density lipoprotein-cholesterol (HDL-C) concentrations decreased, and total cholesterol (T-C):HDL-C ratio increased in those with the GA genotype but not the GG genotype. In addition, with increasing n-3 polyunsaturated fatty acid intake (percentage of total energy intake, %E), T-C:HDL-C ratio decreased in those with the GA genotype, but not in those with the GG genotype. In white SA women, with increasing eicosapentaenoic acid (%E) intake, low-density lipoprotein-cholesterol concentrations decreased in those with the GG genotype but not the GA genotype. CONCLUSIONS: The -238 G4A polymorphism was associated with body fatness in black women. Interactions between -238 G4A genotypes and dietary fat intake on serum lipids and adiposity differed depending on dietary fat intake, but those for serum lipids were not the same in black and white SA women.

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“…The presence of high concentrations of IL-6 is related to inflammation, whereas polymorphisms such as rs1800795 and rs2069845 are associated with obesity and other diseases such as insulin resistance, metabolic syndrome and type 2 diabetes mellitus (Mendoza-Carrera et al 2010, Corpeleijn et al 2010, Steemburgo et al 2009, Tabassum et al 2012. In a study carried out in India with children and adolescents aged 11 to 17 years, the IL-6 polymorphism rs2069845 had its risk allele associated with overweight/obesity, whereas in this same study IL-6 polymorphism rs1800795 was not associated with overweight/obesity (Tabassum et al 2012).…”

Section: Discussionmentioning

confidence: 99%

Association of IL-6 and CRP gene polymorphisms with obesity and metabolic disorders in children and adolescents

Todendi

Klinger

Ferreira

et al. 2015

An. Acad. Bras. Ciênc.

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Activation of adipose tissue inflammation is associated with obesity caused by lipid accumulation in adipocytes. Through this activation, proinflammatory cytokines, such as Interleukin-6 (IL-6) and C-reactive protein (CRP) seem to influence metabolic disorders. The present study evaluated whether polymorphisms in the CRP (rs1205) and IL-6 (rs1800795, rs2069845) genes are associated with the development of metabolic disorders in children and adolescents. A cross-sectional study was performed, consisting of 470 students from the municipality of Santa Cruz do Sul, Brazil, aged 7-17 years. Body mass index (BMI) was classified according to overweight and obesity. Genotyping was performed by real-time Polymerase Chain Reaction (PCR). Anthropometric characteristics, biochemical markers, immunological markers and blood pressure were assessed. Descriptive statistics, chi-square and logistic regression were used for the analyses. No association was detected between the rs1800795 polymorphism and the assessed variables. Individuals with the risk genotype in the rs1205 gene were associated with the risk of developing hypercholesterolemia (OR 2.79; CI 1.40, 5.57; p = 0.003). Carriers of the risk genotype in the rs2069845 gene are associated with the risk of developing obesity (OR 3.07; CI 1.08, 8.72; p = 0.03). The polymorphism rs2069845 was associated with obesity and rs1205 was associated with the risk of developing hypercholesterolemia in Brazilian schoolchildren.

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Influence of CRP, IL6, and TNFA Gene Polymorphisms on Circulating Levels of C-Reactive Protein in Mexican Adolescents

Cited by 26 publications

References 34 publications

Common variants in the CRP gene are associated with serum C-reactive protein levels and body mass index in healthy individuals in Mexico

Common variants in the CRP gene are associated with serum C-reactive protein levels and body mass index in healthy individuals in Mexico

The tumor necrosis factor-α gene -238 G>A polymorphism, dietary fat intake, obesity risk and serum lipid concentrations in black and white South African women

Association of IL-6 and CRP gene polymorphisms with obesity and metabolic disorders in children and adolescents

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