Influence of cross-linking in loading/release applications of polyelectrolyte multilayer assemblies. A review

Ghiorghiță, Claudiu-Augustin; Bucătariu, Florin; Drăgan, Ecaterina Stela

doi:10.1016/j.msec.2019.110050

Cited by 46 publications

(38 citation statements)

References 180 publications

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“…Several reports on strong PE capsules to date show their wide use in many practical applications ranging from the loading and controlled release of therapeutic agents upon minor variations in the environmental characteristics, surface modification and suppression of inter-chain interaction to the degradation/rearrangement of LbL films under the action of physical factors [19,20]. In spite of the fact that weak PE systems can also offer many such advantages, only a few works have been reported.…”

Section: Review Introductionmentioning

confidence: 99%

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

Sharma¹,

Sundaramurthy²

2020

Beilstein J. Nanotechnol.

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Multilayer capsules have been of great interest for scientists and medical communities in multidisciplinary fields of research, such as drug delivery, sensing, biomedicine, theranostics and gene therapy. The most essential attributes of a drug delivery system are considered to be multi-functionality and stimuli responsiveness against a range of external and internal stimuli. Apart from the highly explored strong polyelectrolytes, weak polyelectrolytes offer great versatility with a highly controllable architecture, unique stimuli responsiveness and easy tuning of the properties for intracellular delivery of cargo. This review describes the progress in the preparation, functionalization and applications of capsules made of weak polyelectrolytes or their combination with biopolymers. The selection of a sacrificial template for capsule formation, the driving forces involved, the encapsulation of a variety of cargo and release based on different internal and external stimuli have also been addressed. We describe recent perspectives and obstacles of weak polyelectrolyte/biopolymer systems in applications such as therapeutics, biosensing, bioimaging, bioreactors, vaccination, tissue engineering and gene delivery. This review gives an emerging outlook on the advantages and unique responsiveness of weak polyelectrolyte based systems that can enable their widespread use in potential applications.

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Section: Review Introductionmentioning

confidence: 99%

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

Sharma¹,

Sundaramurthy²

2020

Beilstein J. Nanotechnol.

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“…44 There is some promise in multilayer meshes, but current research has not shown release of antipseudomonal drugs (especially ciprofloxacin) for time periods greater than 4 days. 45,46 A second potential method has been through the use of nanoparticle-loaded hydrogels. Numerous polymeric hydrogels have been developed that are loaded with polyester, polylactic-co-glycolic acid (PLGA) nanoparticles that release over a variety of time frames.…”

Section: Potential Nonstent Topical Therapiesmentioning

confidence: 99%

Antibiotic eluting sinus stents

Thompson

Lim

Banks

et al. 2020

Laryngoscope Investig Oto

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Objectives Chronic rhinosinusitis (CRS) is a multifactorial disease affecting up to 16% of the United States population and disproportionately affecting the cystic fibrosis (CF) patient population. Despite treating the underlying infection, the use of systemic antibiotics has shown little efficacy in alleviation of symptom burden. This review seeks to discuss recent research on novel antibiotic eluting stent therapy in vitro and within animal models as well as the factors that contribute to its efficacy. Data Sources PubMed literature review. Review Methods A review of all published literature related to antibiotic eluting sinus stents was conducted to integrate and summarize this innovative approach to chronic sinus infections. Results Placement of the ciprofloxacin sinus stent (CSS) and ciprofloxacin‐ivacaftor sinus stent (CISS) exhibited improvement in endoscopic and radiographic findings in rabbit CRS models. While the CSS showed an overall trend toward improvement in microscopic findings and a reduction in biofilm mass, there remained a significant quantity of planktonic bacteria due to antibiotic depletion from an initial burst release in the first 48 hours of stent placement. The CISS and ciprofloxacin‐azithromycin sinus stents (CASSs) exhibited controlled antibiotic release over the study period leading to greatly reduced planktonic bacterial load and biofilm mass. In vitro studies indicate that CASS may be just as efficacious at reducing biofilm mass. Conclusion Antibiotic eluting sinus stents show significant promise as a novel therapeutic strategy for CRS. The CISS may have particular promise for the CF patient population by addressing both the infectious and genetic components of disease. Animal studies demonstrate significant promise for translation into human studies. Human clinical trials are warranted to determine the efficacy of antibiotic sinus stents in human patients. Level of Evidence NA

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“…[17][18][19] LbL assembly applied to microparticles was first reported by 20 by the sequential addition of layers of alternatively charged polymers of approximately 2-3 nm in thickness 21 on a template core. These microcapsules are ideally suited to the delivery of macromolecules that can be trapped within the structure of the capsule whereas small molecule drugs readily diffuse out unless they have affinity for a capsule component, 22 layers are crosslinked to improve retention 23 or high drug loading is achieved by use of crystalline drug as the capsule core. 24 One of their interesting attributes is their potential for functionalisation through incorporation nanocomponents which can permit responsiveness to physical stimuli.…”

Section: Introductionmentioning

confidence: 99%

Magnetically responsive layer-by-layer microcapsules can be retained in cells and under flow conditions to promote local drug release without triggering ROS production

et al. 2020

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Influence of cross-linking in loading/release applications of polyelectrolyte multilayer assemblies. A review

Cited by 46 publications

References 180 publications

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

Multilayer capsules made of weak polyelectrolytes: a review on the preparation, functionalization and applications in drug delivery

Antibiotic eluting sinus stents

Magnetically responsive layer-by-layer microcapsules can be retained in cells and under flow conditions to promote local drug release without triggering ROS production

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