Influence of cigarette smoking on the level of mRNA of somatostatin receptor 3 (SSTR3) in the gastric mucosa of patients with functional dyspepsia

Stec−Michalska, Krystyna; Pęczek, Łukasz; Michalski, Błażej; Adamczyk, Marcin; Chojnacki, Jan; Nawrot, Barbara

doi:10.2478/v10039-010-0026-3

Cited by 3 publications

(2 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results are in concert with the previous workers who have examined the effect of smoking in the promotion of H. pylori infection [16][17][18][19][20][21] .…”

Section: Discussionsupporting

confidence: 78%

Association of smoking, alcohol and NSAIDs use with expression of cag A and cag T genes of Helicobacter pylori in salivary samples of asymptomatic subjects

Ghosh

Bodhankar

2012

Asian Pacific Journal of Tropical Biomedicine

View full text Add to dashboard Cite

“…Our results are in concert with the previous workers who have examined the effect of smoking in the promotion of H. pylori infection [16][17][18][19][20][21] .…”

Section: Discussionsupporting

confidence: 78%

Association of smoking, alcohol and NSAIDs use with expression of cag A and cag T genes of Helicobacter pylori in salivary samples of asymptomatic subjects

Ghosh

Bodhankar

2012

Asian Pacific Journal of Tropical Biomedicine

View full text Add to dashboard Cite

“…Moreover, smoking leads to decreasing the somatostatin receptor 3 mRNA level in gastric mucosa. Somatostatin is a regulatory peptide produced by neuroendocrine cells that has inhibitory action on the secretion of gastric acid [62]. …”

Section: Discussionmentioning

confidence: 99%

Smoking Status and Prevalence of Upper Gastrointestinal Disorders

Esmaillzadeh¹,

Keshteli

Tabesh³

et al. 2014

Digestion

View full text Add to dashboard Cite

Background: Lifestyle and environmental factors affecting upper gastrointestinal (GI) disorders are different in developing countries than those in developed nations. Objective: This study aimed to examine the association between smoking status and upper GI disorders among a large group of the Iranian adult population. Methods: This cross-sectional study was conducted among 1,933 adult men in Isfahan, Iran. Smoking status was assessed by a self-administered questionnaire. Required information on GI health was collected through the use of the validated ROME III questionnaire. Individuals who reported having heartburn sometimes, often, or always in the last 3 months were considered as having epidemiologic gastroesophageal reflux disease (GERD), and those who reported having heartburn often or always were considered as having clinical GERD. Subjects who reported having functional dyspepsia (FD) symptoms (based on the ROME III criteria) sometimes, often, or always in the last 3 months were considered as having epidemiologic FD, and those who reported having these disorders often or always were considered as having clinical FD. Results: Smoking was prevalent among 7.8% of the study population. FD and GERD was prevalent among 12.6% (n = 244) and 22.3% (n = 432), respectively. Smoking was not associated with GERD by either the epidemiologic or clinical definition. Although the association between smoking and FD (epidemiologic definition) was not statistically significant, smokers had an 83% higher risk of suffering from clinical FD compared with nonsmokers after taking potential confounders into account [odds ratio (OR) = 1.83, 95% CI: 1.12-3.00; p = 0.01]. Smokers had a 57% higher risk for epidemiologic postprandial fullness (OR = 1.57, 95% CI: 1.05-2.33; p = 0.02) and a 92% higher risk for clinical epigastric pain compared with nonsmokers (OR = 1.92, 95% CI: 1.02-3.62; p = 0.04). We found no significant association between smoking and severity of upper GI disorders. Conclusion: This large population-based study indicated that smoking was not associated with GERD and epidemiologic FD. However, smoking was significantly associated with clinical FD, postprandial fullness, and epigastric pain.

show abstract

Overlap of functional dyspepsia and GERD—diagnostic and treatment implications

Quigley

Lacy

2013

Nat Rev Gastroenterol Hepatol

View full text Add to dashboard Cite

GERD and functional dyspepsia are the two most prevalent upper gastrointestinal disorders. Gastro-oesophageal reflux is most commonly diagnosed using the cardinal symptoms of heartburn and regurgitation. Patients might also be diagnosed using a questionnaire, after empiric treatment with an acid suppressant, after upper endoscopy or by pH testing. Functional dyspepsia is best diagnosed using symptoms outlined by the Rome committee in conjunction with a normal upper endoscopy. Theoretically, distinguishing these two populations should be easy for all health-care providers. In reality, however, carefully separating out these two populations can be quite difficult, as substantial overlap exists epidemiologically, symptomatically and even diagnostically. This overlap renders precise diagnosis a challenge; given the limited treatment options, the primary goal is to identify those patients who will respond to acid suppressive therapy. Despite the frequency with which functional dyspepsia and GERD overlap, remarkably few studies have investigated this overlap. Most recommendations are based on data derived from separate studies of functional dyspepsia and GERD. A further limitation of existing studies is their failure to differentiate between the various diagnostic categories into which the individual presenting with heartburn might belong.

show abstract

Influence of cigarette smoking on the level of mRNA of somatostatin receptor 3 (SSTR3) in the gastric mucosa of patients with functional dyspepsia

Cited by 3 publications

References 22 publications

Association of smoking, alcohol and NSAIDs use with expression of cag A and cag T genes of Helicobacter pylori in salivary samples of asymptomatic subjects

Association of smoking, alcohol and NSAIDs use with expression of cag A and cag T genes of Helicobacter pylori in salivary samples of asymptomatic subjects

Smoking Status and Prevalence of Upper Gastrointestinal Disorders

Overlap of functional dyspepsia and GERD—diagnostic and treatment implications

Contact Info

Product

Resources

About