Influence of cholesterol status on blood lipid and lipoprotein enzyme responses to aerobic exercise

Abstract

To compare postexercise changes in plasma lipids and lipoprotein enzymes in 13 hypercholesterolemic (HC) and 12 normocholesterolemic men [total cholesterol (TC) 252 +/- 5 vs. 179 +/- 5 mg/dl], fasting blood samples were obtained 24 h before, immediately, 24, and 48 h after a single bout of treadmill walking (70% peak O(2) consumption, 500 kcal expenditure). Significant findings (P < 0.05 for all) for plasma volume-adjusted lipid and enzyme variables were that TC, low-density-lipoprotein cholesterol, and cholesterol ester transfer protein activity were higher in the HC group but did not influence the lipid responses to exercise. Across groups, TC was transiently reduced immediately after exercise but returned to baseline levels by 24 h postexercise. Decreases in triglyceride and increases in high-density-lipoprotein cholesterol (HDL-C) and HDL(3)-C were observed 24 h after exercise and lasted through 48 h. Lipoprotein lipase activity was elevated by 24 h and remained elevated 48 h after exercise. HDL(2)-C, cholesterol ester transfer protein activity, hepatic triglyceride lipase, and lecithin: cholesterol acyltransferase activities did not change after exercise. These data indicate that the exercise-induced changes in HDL-C and triglyceride are similar in HC and normocholesterolemic men and may be mediated, at least in part, by an increase in lipoprotein lipase activity.

Is weight loss the optimal target for obesity-related cardiovascular disease risk reduction?

“…The augmented insulin sensitivity is apparent immediately after exercise (36) and persists for 20 h to 48 h thereafter (35,37,38). It is also well established that a single bout of aerobic exercise results in 10% to 25% reductions in triglycerides (TGs) and 7% to 15% increases in high-density lipoprotein (HDL) cholesterol levels (11,(41)(42)(43). These lipid changes become apparent between 24 h and 48 h after exercise in both untrained (41,42) and trained subjects (43) in response to caloric expenditures of 350 kcal to 500 kcal and 1000 kcal, respectively.…”

“…It is also well established that a single bout of aerobic exercise results in 10% to 25% reductions in triglycerides (TGs) and 7% to 15% increases in high-density lipoprotein (HDL) cholesterol levels (11,(41)(42)(43). These lipid changes become apparent between 24 h and 48 h after exercise in both untrained (41,42) and trained subjects (43) in response to caloric expenditures of 350 kcal to 500 kcal and 1000 kcal, respectively. Additionally, the blood pressure-lowering effect of acute aerobic exercise has been long established (44).…”

Comparison of Three Protocols: Dietary Therapy and Physical Activity, Acupuncture, or Laser Acupuncture in Management of Obese Females

“…Bounds et al [25] revealed that exercise resulted in an increase in HDL-c (10.7%) and a concomitant fall in triglyceride (-25%) and total cholesterol (-3.5%), which may be mediated; at least in part; by an increase in lipoprotein lipase activity [26]. These results came against current ones.…”

Influence of Heat Exposure on Serum Lipid and Lipoprotein Cholesterol in Young Male Subjects.

“…These physiological reactions may also occur when exposed to heat while keeping the body at rest. Physical exercise has been reported to cause acute reduction in serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and triglyceride (TG) while it increases high-density lipoprotein cholesterol (HDL-C) and free fatty acid (FFA) [1][2][3][4][5] . Due to the scarcity of reports it is not known exactly whether the rising body temperature caused by wholly heat exposure accounts for the changes in serum lipids.…”