“…Chitosan is poorly soluble in water at physiologic pH values, but it forms salts with inorganic or organic acids, such as hydrochloride and glutamic acid, that are soluble in water and possess better characteristics than chitosan itself, such as mucoadhesiveness and the ability to enhance the penetration of neuroactive agents into the CNS (Dalpiaz et al, 2008;Gavini et al, 2011;Maestrelli et al, 2004). Chitosan is also characterized by the ability to reversibly open tight junctions, which is associated with a potential increase in the transcellular transport of drugs across the olfactory mucosa (Durhia et al, 2010).…”