Influence of chemical peeling on the skin stress response system

Kimura, Ayako; Kanazawa, Nobuo; Li, Hong-Jin; Yonei, Nozomi; Yamamoto, Yuki; Furukawa, Fukumi

doi:10.1111/j.1600-0625.2012.01495.x

Cited by 14 publications

(12 citation statements)

References 26 publications

(31 reference statements)

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“…The inappropriate choice of trichloroacetic acid concentration or its action time, relative to the area treated, can lead to significant side effects [5]. The complications incidence is directly proportional to the depth at which the procedure is performed, which in turn, is directly influenced by the concentration of the product used [4,6]. Identifying ideal candidates for this type of procedure plays a defining role in obtaining optimum results [7].…”

Section: Resultsmentioning

confidence: 99%

“…Thus for patients with closed phototypes, Fitzpatrik III-VI, who present an additional risk of pathological scarring or developing dyschromic phenomena, low concentrations (10-25%) shall always be used [2,4,6].…”

Section: Resultsmentioning

confidence: 99%

“…The post-procedural results within the range of chemical peels vary in direct proportion to the level of the depth at which they are carried out and the degree of experience of the medical procedure provider [2,6].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Use of Trichloroacetic Acid in Treating Facial Hyperpigmentation

Jecan¹,

Nicolau²,

Florescu³

et al. 2017

Mat.Plast.

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This paper aims to present the benefits and results of using TCA of high concentration of 50%, in conjunction with the presentation of adverse reactions and complications. The study was conducted in Arestetic Clinic Galai during the period 10 Dec. 2015-1 Nov. 2016, on a group of 12 patients, of which 10 women and 2 men. The product used was Easy TCA 50% manufactured by SkinTech laboratories. Three coats of TCA were applied at intervals of 4 minutes each. The end result was assessed at 21 days, when the entire surface of the skin was peeled and re-epithelized. Patients were asked to assess the degree of satisfaction on a scale of 1 to 10, with 1 being the least satisfactory and 10 being the most satisfactory. As a result of this assessment, 10 patients rated the degree of satisfaction with 10 (83%) and 2 patients rated the degree of satisfaction with 9 (17%), with an average degree of satisfaction of 9.83. At 21 days, dyschromias and hyperpigmentations completely disappeared in 9 patients, while a female patient and 2 male patients still presented with barely noticeable spots. These three persons were subjected to the second peeling after 2 months, this time in two layers, and these hyperpigmentations disappeared at the end.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Use of Trichloroacetic Acid in Treating Facial Hyperpigmentation

Jecan¹,

Nicolau²,

Florescu³

et al. 2017

Mat.Plast.

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“…The mechanism underlying TCA induced hyperpigmentation may be related to the skin stress response system. A recent study suggests that TCA activates the skin stress response system by directly inducing pro-opiomelanocortin and melanocortin-1 receptor production by keratinocytes (Kimura et al, 2012). Persistent erythema is erythema lasting longer than expected for an individual peel (Monheit, 2004).…”

Section: Discussionmentioning

confidence: 98%

Chemical burn following 50% trichloroacetic acid for acne: Presentation of a case and a focused review

Liu

Khachemoune

Rashid³

2016

Journal of Dermatology & Dermatologic Surgery

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Background: Chemical peels are widely used minimally invasive procedures with both cosmetic and medical indications. Although known for their general safety and efficacy, peels can rarely result in significant complications.Objective: Here we report the first case in the peer-reviewed literature of chemical burn from erroneous home use of 50% trichloroacetic acid.Methods: A focused literature review was performed of complications relating to chemical peels. Results: Chemical burns from trichloroacetic acid peels are rare. To our knowledge, this is the first such case reported with supporting histopathological data.Conclusions: Physicians must be aware of the potential complications of chemical peels, prevention strategies, and treatment modalities. Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http:// creativecommons.org/licenses/by-nc-nd/4.0/).

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“…TCA is usually used as a superficial peeling agent; however, higher TCA concentrations will penetrate to the mid-reticular dermis [ 10 ]. TCA peeling induces the skin stress response system resulting in reconstitution of the epidermis and dermis through wound healing processes [ 11 ]. This ability makes the TCA peeling a potential therapeutic option for cutaneous leishmaniasis [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

A Comparison between the Effects of Glucantime, Topical Trichloroacetic Acid 50% plus Glucantime, and Fractional Carbon Dioxide Laser plus Glucantime on Cutaneous Leishmaniasis Lesions

Jaffary

Nilforoushzadeh

Siadat

et al. 2016

Dermatology Research and Practice

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Background. Cutaneous leishmaniasis is an endemic disease in Iran. Pentavalent antimonial drugs have been the first line of therapy in cutaneous leishmaniasis for many years. However, the cure rate of these agents is still not favorable. This study was carried out to compare the efficacies of intralesional glucantime with topical trichloroacetic acid 50% (TCA 50%) + glucantime and fractional carbon dioxide laser + glucantime in the treatment of cutaneous leishmaniasis. Methods. A total of 90 patients were randomly divided into three groups of 30 to be treated with intralesional injection of glucantime, a combination of topical TCA 50% and glucantime, or a combination of fractional laser and glucantime. The overall clinical improvement and changes in sizes of lesions and scars were assessed and compared among three groups. Results. The mean duration of treatment was 6.1 ± 2.1 weeks in all patients (range: 2–12 weeks) and 6.8 ± 1.7, 5.2 ± 1.0, and 6.3 ± 3.0 weeks in glucantime, topical TCA plus glucantime, and fractional laser plus glucantime groups, respectively (P = 0.011). Complete improvement was observed in 10 (38.5%), 27 (90%), and 20 (87%) patients of glucantime, glucantime + TCA, and glucantime + laser groups, respectively (P < 0.001). Conclusion. Compared to glucantime alone, the combination of intralesional glucantime and TCA 50% or fractional CO2 laser had significantly higher and faster cure rate in patients with cutaneous leishmaniasis.

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Influence of chemical peeling on the skin stress response system

Cited by 14 publications

References 26 publications

Use of Trichloroacetic Acid in Treating Facial Hyperpigmentation

Use of Trichloroacetic Acid in Treating Facial Hyperpigmentation

Chemical burn following 50% trichloroacetic acid for acne: Presentation of a case and a focused review

A Comparison between the Effects of Glucantime, Topical Trichloroacetic Acid 50% plus Glucantime, and Fractional Carbon Dioxide Laser plus Glucantime on Cutaneous Leishmaniasis Lesions

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