Ceftaroline fosamil achieved high clinical cure and microbiological success rates, was efficacious for cSSSIs caused by MRSA and other common cSSSI pathogens and was generally well tolerated. Ceftaroline fosamil has the potential to provide a monotherapy alternative for treatment of cSSSIs.
Tigecycline is safe and effective in hospitalized patients with serious infection caused by MRSA. There were too few cases of VRE to draw any conclusions.
Breast reconstruction involves two major conditions: to be oncologically safe and to respect the aesthetic of the reconstructed breast. Moreover, every healthcare system in the world manifests a keen tendency to cut back on medical costs, which influences our surgical techniques and breast reconstruction procedures. The use of biological matrices like the acellular dermal matrix has become an acknowledged alternative in implant-based breast reconstruction, in spite of the many impediments and controversies that surround it. However, these matrices are costly and less attainable as compared to synthetic meshes that are conservative with resources and unyielding to the formation of biofilm bacteria. Accordingly, we decided to research the impact of synthetic meshes in implant-based breast reconstruction.
RezumatReconstrucţia de sân implică două decizii majore: alegerea momentului optim şi a tehnicii adecvate de reconstrucţie pentru fiecare pacientă, luând în considerare complicaţiile şi riscurile care pot rezulta în urma acestor decizii. Prin selectarea atentă a pacientelor şi individualizarea reconstrucţiei de sân, riscurile şi complicaţiile acestei proceduri pot fi minimizate, cu rezultat estetic bun şi satisfacţie ridicată în rândul pacientelor. Reconstrucţia de sân poate fi realizată prin 3 modalităţi distincte: reconstrucţia imediată -la momentul mastectomiei, reconstrucţia secundară -la finalizarea tratamentului adjuvant şi reconstrucţia imediat-întârziată care utilizează ambele metode precedente -include expansiunea tisulară la momentul mastectomiei şi reconstrucţia definitivă la finalizarea tratamentului adjuvant. Strategiile perfecţionate timp de decenii în chirurgia reconstructivă a sânului au făcut posibilă reconstrucţia imediată a sânului oferind pacientelor şansa de a se recupera după o intervenţie de mastectomie cu un nou sân reconstruit. Deşi nu toate pacientele aleg reconstrucţia sânului, procentele celor care optează pentru reconstrucţie sunt în continuă creştere, iar tehnici noi şi îmbunătăţite se dezvoltă rapid.Cuvinte cheie: cancer de sân, mastectomie, reconstrucţie de sân, conservarea ţesutului cutanat, implant mamar
Botulinum neurotoxins (BoNTs) are responsible for botulism in humans and vertebrates, being one of the six most catastrophic potential bioterrorism agents. This are ~150 kDa proteins, assembled as a ~50 kDa light chain (LC) and a ~100 kDa heavy chain (HC). The LC acts like a zinc metalloproteinase that cleaves three proteins in neurons, members of the SNARE (Soluble N-ethylmaleimide sensitive fusion attachment protein receptors) family: VAMP (vesicle-associated membrane protein) / synaptobrevin, SNAP-25 (synaptosomal-associated protein 25) and syntaxin. After cleavage of any of this proteins, neurotransmission is blocked and flaccid paralysis of the muscle is installed. This extraordinary restricted tropism for the cholinergic presynaptic membrane makes this drug unique regarding its toxicity, pharmacological and therapeutic use. Taking into consideration the potential of this substance, this paper aims to summarize the most relevant data regarding the mechanism of actions and its main clinical applications, in order to improve medical practice. Therefore, we presented the mechanism of action in order to understand its usage in different pathologies, such as dystonias, spasticity, nephrologic and urologic conditions, cosmetic use, depression, gastroenterologic and proctologic diseases, dermatologic conditions, pathologies specific to plastic surgery and also the role of BoNT therapy in pain management. It is well documented in the literature that important discoveries have been made through recent experimental and clinical studies. Even so, there is still much to learn about the therapeutic action of this drug in terms of molecular and pathophysiological mechanisms, in order to benefit of the whole healing potential of this amazing toxin.
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