Influence of cardiac hemodynamic variables on retinal vessel density measurement on optical coherence tomography angiography in patients with myocardial infarction

Arnould, Louis; Guenancia, Charles; Gabrielle, Pierre‐Henry; Pitois, Stéphane; Baudin, Florian; Pommier, Thibaut; Zeller, Marianne; Bron, A.; Creuzot‐Garcher, Catherine; Cottin, Yves

doi:10.1016/j.jfo.2019.07.026

Cited by 20 publications

(22 citation statements)

References 20 publications

(20 reference statements)

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“…In the EYE-MI study, our group previously highlighted the association between inner vessel length density in OCT-A imaging and cardiovascular risk profile 16 . We also demonstrated that inner vessel length density was independent from systemic hemodynamic variables 21 . In the present study, patients presenting an ACS showed similar inner vessel length density as those in the EYE-MI study, measured respectively at 19.76 mm −1 and 19.70 mm −1 .…”

Section: Discussionsupporting

confidence: 54%

Vascular density with optical coherence tomography angiography and systemic biomarkers in low and high cardiovascular risk patients

Hannappe

Arnould

Méloux

et al. 2020

Sci Rep

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We aimed to compare retinal vascular density in Optical Coherence Tomography Angiography (OCT-A) between patients hospitalized for acute coronary syndrome (ACS) and control patients and to investigate correlation with angiogenesis biomarkers. Patients hospitalized for an acute coronary syndrome (ACS) in the Intensive Care Unit were included in the “high cardiovascular risk” group while patients without cardiovascular risk presenting in the Ophthalmology department were included as “control”. Both groups had blood sampling and OCT-A imaging. Retina microvascularization density in the superficial capillary plexus was measured on 3 × 3 mm angiograms centered on the macula. Angiopoietin-2, TGF-β1, osteoprotegerin, GDF-15 and ST-2 were explored with ELISA or multiplex method. Overall, 62 eyes of ACS patients and 42 eyes of controls were included. ACS patients had significantly lower inner vessel length density than control patients (p = 0.004). A ROC curve found that an inner vessel length density threshold below 20.05 mm−1 was moderately associated with ACS. Significant correlation was found between serum levels of angiopoietin-2 and osteoprotegerin, and retinal microvascularization in OCT-A (R = − 0.293, p = 0.003; R = − 0.310, p = 0.001). Lower inner vessel length density measured with OCT-A was associated with ACS event and was also correlated with higher concentrations of angiopoietin-2 and osteoprotegerin.

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Section: Discussionsupporting

confidence: 54%

Vascular density with optical coherence tomography angiography and systemic biomarkers in low and high cardiovascular risk patients

Hannappe

Arnould

Méloux

et al. 2020

Sci Rep

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“…Arnould et al [ 44 ] analyzed retinal VD based on OCTA in 30 patients with myocardial infarction during the acute phase and three months after cardiac rehabilitation. The authors found no significant relationship between retinal vascular density and hemodynamic variables in patients with myocardial infarction.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Chronic Heart Failure on Retinal Vessel Density Assessed by Optical Coherence Tomography Angiography in Children with Dilated Cardiomyopathy

Rakusiewicz

Kanigowska

Hautz

et al. 2021

JCM

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(1) Introduction: The aim of this study is to assess retinal vessel density (VD) in the superficial capillary plexus layer (SP) and deep capillary plexus layer (DP) in children with chronic heart failure (CHF) in the course of dilated cardiomyopathy (DCM) using optical coherence tomography angiography (OCTA). (2) Methods: Thirty children with CHF due to DCM lasting more than six months, with an enlarged left ventricle and impaired left ventricular systolic function (left ventricular ejection fraction (LVEF) ≤ 55%), were enrolled to have both their eyes assessed for this study. Mean age of the children was 9.9 ± 3.57 years. The control group consisted of an additional 30 children without CHF (mean age 11.27 ± 3.33 years) matched for age and gender against the study group. All participants underwent transthoracic echocardiography to measure LVEF using Simpson method. Blood serum was tested for N-terminal-pro-brain natriuretic peptide (NT-proBNP) marker value. All children underwent OCTA with evaluation of the foveal avascular zone (FAZ), whole superficial vessel density (wsVD), foveal superficial vessel density (fsVD), parafoveal superficial vessel density (psVD), whole deep vessel density (wdVD), foveal deep vessel density (fdVD), parafoveal deep vessel density (pdVD), whole thickness (WT), foveal thickness (FT), and parafoveal thickness (PFT). (3) Results: Retinal VD in SP was significantly lower in children with CHF as compared to the controls. The following SP parameters in the study group were statistically significantly lower than these same measurements for the control group. Details, with study group findings quantified first, include wsVD (46.2% vs. 49.83%, p < 0.05), fsVD (18.07% vs. 24.15%, p < 0.05), and psVD (49.24% vs. 52.51%, p < 0.05). The WT (311.03 micrometers (μm) vs. 323.55 μm, p < 0.05), FT (244.57 μm vs. 256.98 μm, p < 0.05), and PFT (320.63 μm vs. 332.02 μm, p < 0.05). No significant differences in DP retinal VD were found between the two groups. No statistically significant differences in the FAZ were found. The fsVD and FT were correlated with biometry and the age of the study participants. There was a correlation between FAZ and FT (p < 0.001). There were no correlations between retinal VD in both plexuses and refractive error, sex, NT-proBNP, and LVEF. (4) Conclusions: In children with CHF in the course of DCM as compared to the control group, significantly decreased retinal VD in SP was observed. The results of our study indicate that measurements of the OCTA may be a useful diagnostic method in children with chronic heart failure, but it is necessary to conduct further studies in larger groups of participants and long-term observation of these patients.

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“…Arnould et al examined the effect of left-sided hemodynamic variables on retinal microvasculature using OCTA in patients with myocardial infarction. 32 The authors of this study were unable to demonstrate any significant association between retinal vascular density on OCTA and left-sided hemodynamic variables, including cardiac output. They also assessed the effect of improvement in left ventricular ejection fraction and indexed cardiac output on retinal vascular density at 3 months follow-up visit after cardiac rehabilitation in these patients.…”

Section: Correlations Of Retinal and Choroidal Microvascular Perfusionmentioning

confidence: 60%

“…Although the authors hypothesized that several alterations might occur in the retinal vessels and choroidal thickness of these patients, there were no statistically significant differences in terms of retinal arteriole caliber, retinal venule caliber, and subfoveal choroidal thickness between the patients with chronic systolic heart failure and healthy controls. Arnould et al examined the effect of left‐sided hemodynamic variables on retinal microvasculature using OCTA in patients with myocardial infarction 32 . The authors of this study were unable to demonstrate any significant association between retinal vascular density on OCTA and left‐sided hemodynamic variables, including cardiac output.…”

Section: Discussionmentioning

confidence: 76%

“…The potential role of OCTA has also been investigated in a variety of cardiac pathologies, including coronary artery disease, left heart failure 29–32 . Arnould et al showed that retinal inner vessel density of the SCP assessed by OCTA was reduced in the patients presenting with acute coronary syndrome compared to healthy volunteers and was associated with the cardiovascular risk profile in this patient population 29 .…”

Section: Discussionmentioning

confidence: 99%

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The relationship between retinal microcirculation and right heart catheterization and echocardiography findings in patients with idiopathic pulmonary arterial hypertension

Hekimsoy

Şekeroğlu

et al. 2021

Microcirculation

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Objective To determine the possible alterations of retinal microcirculation associated with right‐sided intracardiac pressures in patients with IPAH. Methods Twenty patients with IPAH and 20 age‐ and sex‐matched healthy controls were included in the study. Hemodynamic data were obtained from the most recent right heart catheterization. Echocardiographic examination was performed within 24 h of ophthalmological examination. For the right eyes of all participants, high‐resolution scans of chorioretinal microvascular networks at different depths of the retina were captured via OCT angiography. Results The perfusion of the superﬁcial and deep capillary plexus (SCP and DCP), and choriocapillaris (CCP) flow area were significantly lower than those in healthy control subjects (p < .05 for all). In IPAH group, PVR and mPAP were correlated significantly with the perfusion measurements at SCP and DCP (r = .461, r = .626 and r = .625, r =0.730, respectively, p < .05). sPAP and TRV were positively correlated with the perfusion measurements at SCP and DCP (r = .600, r = .662 and r = .670, r = .655 p < .05). Conclusions The positive correlation of retinal perfusion at SCP and DCP with right‐sided echocardiographic and hemodynamic measurements unveiled that retinal microcirculation is affected by the pressure alterations in the pulmonary circulation of IPAH patients.

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Influence of cardiac hemodynamic variables on retinal vessel density measurement on optical coherence tomography angiography in patients with myocardial infarction

Cited by 20 publications

References 20 publications

Vascular density with optical coherence tomography angiography and systemic biomarkers in low and high cardiovascular risk patients

Vascular density with optical coherence tomography angiography and systemic biomarkers in low and high cardiovascular risk patients

The Impact of Chronic Heart Failure on Retinal Vessel Density Assessed by Optical Coherence Tomography Angiography in Children with Dilated Cardiomyopathy

The relationship between retinal microcirculation and right heart catheterization and echocardiography findings in patients with idiopathic pulmonary arterial hypertension

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