The relationship between retinal microcirculation and right heart catheterization and echocardiography findings in patients with idiopathic pulmonary arterial hypertension

Abstract

Objective To determine the possible alterations of retinal microcirculation associated with right‐sided intracardiac pressures in patients with IPAH. Methods Twenty patients with IPAH and 20 age‐ and sex‐matched healthy controls were included in the study. Hemodynamic data were obtained from the most recent right heart catheterization. Echocardiographic examination was performed within 24 h of ophthalmological examination. For the right eyes of all participants, high‐resolution scans of chorioretinal microvascular networks at different depths of the retina were captured via OCT angiography. Results The perfusion of the superficial and deep capillary plexus (SCP and DCP), and choriocapillaris (CCP) flow area were significantly lower than those in healthy control subjects (p < .05 for all). In IPAH group, PVR and mPAP were correlated significantly with the perfusion measurements at SCP and DCP (r = .461, r = .626 and r = .625, r =0.730, respectively, p < .05). sPAP and TRV were positively correlated with the perfusion measurements at SCP and DCP (r = .600, r = .662 and r = .670, r = .655 p < .05). Conclusions The positive correlation of retinal perfusion at SCP and DCP with right‐sided echocardiographic and hemodynamic measurements unveiled that retinal microcirculation is affected by the pressure alterations in the pulmonary circulation of IPAH patients.

Persistent reduction of retinal microvascular vessel density in patients with moderate and severe COVID-19 disease

“…If this were the case, VD of the retina measured by OCT-A would be of use as a marker of widespread organ injury in post-COVID-19 patients. Hekimsoy et al 33 have already established a negative correlation between retinal perfusion and idiopathic pulmonary arterial hypertension, a pathology that has been studied in recent times in the context of COVID-19 34 and that results in a higher fatality rate when SARS-CoV-2 infection occurs. Further studies to correlate systemic signs/symptoms are necessary to elucidate this question.…”

Visualizing the spatiotemporal pattern of yolk sac membrane vascular network by enhanced local fractal analysis

“…distribution of vascular complexity, the images of the YSM vascular network were divided into multi-zones in two ways. Such division strategies have been widely used,5,25,36 and it makes the comparison of different vascular networks possible. In the present work, it allows a semi-quantitative analysis of the YSM vascular networks at different developmental stages.…”