Influence of BOL on hyaluronic acid, laminin and hyperplasia in hepatofibrotic rats

Abstract

The BOL has certain therapeutic effect on the experiment hepatofibrosis. Its mechanisms might include: protecting the function of liver cells, inhibiting excessive synthesis and secretion of extracellular matrix from hepatic stellate cells, relieving the capillarization of hepatic sinusoid, improving liver micro-circulation, and regulating immune function.

Extravasated platelet aggregation in the livers of rats with drug-induced hepatic sinusoidal obstruction syndrome

“…SOS diagnosis is usually supported by imaging modalities that demonstrate changes typical of sinusoidal obstruction. Liver biopsy is diagnostic but is not usually needed; moreover, concurrent coagulopathy or thrombocytopenia make it difficult to acquire biopsy samples (28). Although thrombocytopenia in SOS usually results from hypersplenism, decreased platelet counts have been observed earlier than splenomegaly (15).…”

“…These growth factors can explain the liver injury in SOS. For example, TXA2 can cause central vein occlusion and portal hypertension, (37) and thrombospondin-activated TGF-β can cause collagen deposition in the peri-sinusoidal space and inhibit substance exchange in the space of Disse (28). TGF-β can also increase serum bilirubin concentration and may be responsible for an abnormal ICG retention rate.…”

Ginkgo biloba extract reverses CCl4–induced liver fibrosis in rats

“…D-penicillamine, which blocks intra-and interchain crosslinking in the newly formed collagen molecules, was found to be ineffective on preventing the progression of hepatic fibrosis and was associated with a high incidence of serious side effects. Medicinally useful plants have made a significant contribution to current medical practice and traditional Chinese herbs are well known for their cheap prices and negligible side effects [31][32][33][34][35][36][37][38][39][40][41] . GbE is a well-known and inexpensive herb that has been used to improve blood circulation without ill effects for centuries in traditional Chinese medicine.…”

Serum liver fibrosis markers discriminate significant liver inflammation in chronic hepatitis B patients with normal or near‐normal alanine aminotransferase

“…Our model also indicated that HA was able to discriminate significant inflammation with an AUC of 0.767. LN reflected basement membrane transformation and had some relation to portal hypertension . It was reported that the serum LN level increased with fibrosis stages in patients with chronic viral hepatitis and was considered to reflect both LN synthesis and LN degradation .…”