Influence of body mass index on prognosis in gynecological malignancies

Münstedt, Karsten; Wagner, Mathias; Kullmer, U.; Hackethal, Andreas; Franke, Folker E.

doi:10.1007/s10552-008-9152-7

Cited by 79 publications

(75 citation statements)

References 36 publications

(40 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Three observational cohorts (31,33,34) and the 3 treatment cohorts (9, 24, 25) did not report HRs and so were not included in our initial meta-analysis. All of these studies reported that survival time did not differ significantly between BMI strata, with the exception of the study by Munstedt and colleagues, which found a trend toward improved survival in women who were obese (31).…”

Section: Systematic Reviewmentioning

confidence: 99%

“…All of these studies reported that survival time did not differ significantly between BMI strata, with the exception of the study by Munstedt and colleagues, which found a trend toward improved survival in women who were obese (31). Estimates for 2 of these studies (25,31) were, however, included in the previous meta-analysis (8), thus we conducted a sensitivity analysis including this additional information.…”

Section: Systematic Reviewmentioning

confidence: 99%

See 1 more Smart Citation

Obesity and Ovarian Cancer Survival: A Systematic Review and Meta-analysis

Protani

Nagle

Webb

2012

Cancer Prevention Research

129

View full text Add to dashboard Cite

Studies that have examined the association between obesity and ovarian cancer survival have provided conflicting results. We reviewed and quantitatively summarized existing evidence, exploring potentially important sources of variability, such as the timing of body mass index (BMI) assessment and different cutpoints used to categorize BMI. A systematic search of MEDLINE and EMBASE was conducted to identify original data evaluating the association between obesity and survival in women with ovarian cancer. Adjusted hazard ratios (HR) from studies were pooled using a random-effects model. The meta-analysis of 14 studies showed slightly poorer survival among obese than in non-obese women [pooled HR, 1.17; 95% confidence interval (CI), 1.03-1.34]. This estimate did not vary appreciably when BMI was measured before diagnosis (1.13; 0.95-1.35), at the time of diagnosis (1.13; 0.81-1.57) or at the commencement of chemotherapy (1.12; 0.96-1.31). We found a slightly stronger association in studies that only included women with a BMI 30 in their "obese" group (1.20) than in studies that also included overweight women (BMI 25; 1.14). Women with ovarian cancer who are obese appear to have slightly worse survival than non-obese women. However, there is a large amount of inter-study variation, which means that no solid conclusions can be drawn. Cancer Prev Res; 5(7); 901-10. Ó2012 AACR.

show abstract

Section: Systematic Reviewmentioning

confidence: 99%

Section: Systematic Reviewmentioning

confidence: 99%

Obesity and Ovarian Cancer Survival: A Systematic Review and Meta-analysis

Protani

Nagle

Webb

2012

Cancer Prevention Research

129

View full text Add to dashboard Cite

show abstract

“…The association between obesity and the prognosis of endometrial cancer remains controversial. Previous studies have suggested that obesity is associated with a worse prognosis, while there no relationship seen in other studies (10)(11)(12)(13) that a high BMI was not associated with the patient survival outcome, but showed a lower recurrence although not of statistical significance. This is probably because an increasing BMI shows a lower FIGO stage, a higher proportion of well-differentiated endometrioid type tumors, and a lower risk factor for recurrence such as lymph node/ovarian metastasis, as well as positive cytology as defined by Keys et al in GOG 99 (14,40).…”

Section: Discussionmentioning

confidence: 77%

“…However, the influence of a high BMI on the prognosis of endometrial carcinoma remains controversial. Obesity has been associated with a worse prognosis of endometrial carcinoma in several published studies, although there was no association in other and in Korean population studies (10)(11)(12)(13)(14). Obesity was once a contraindication for advanced laparoscopic procedures (15,16), although this has recently been reconsidered (17).…”

Section: Introductionmentioning

confidence: 99%

Feasibility and Safety of Laparoscopic Surgery for Obese Korean Women with Endometrial Cancer: Long-Term Results at a Single Institution

Baek

Suk

Jung

et al. 2014

Journal of Minimally Invasive Gynecology

View full text Add to dashboard Cite

The purpose of this study was to evaluate the surgical feasibility of and survival outcome after laparoscopy in obese Korean women with endometrial cancer which has recently been increasing. We reviewed the medical records of the patients treated at our medical institution between 1999 and 2012. The patients were divided into three groups, nonobese (Body Mass Index [BMI] < 25.0), overweight (BMI 25-27.99), and obese (BMI ≥ 28.0). These patient groups were compared in terms of their clinical characteristics, treatment methods, as well as surgical and survival outcomes. In total, 55 of the 278 eligible patients were obese women. There were no differences in the three groups in terms of the proportion of patients who underwent lymphadenectomy, their cancer stage, histologic type, type of adjuvant treatment administered, intra-, post-operative, and longterm complications, operative time, number of removed lymph nodes, blood loss, and duration of hospitalization (P = 0.067, 0.435, 0.757, 0.739, 0.458, 0.173, 0.076, 0.124, 0.770, 0.739, and 0.831, respectively). The Disease-Free Survival (DFS) times were 139.1 vs. 121.6 vs. 135.5 months (P = 0.313), and the Overall Survival (OS) times were 145.2 vs. 124.8 vs. 139.5 months (P = 0.436) for each group, respectively. Obese women with endometrial cancer can, therefore, be as safely managed using laparoscopy as women with normal BMIs.

show abstract

“…Apart from this, studies have shown an inverse relationship between body mass index (BMI) and tumour biology/ grading [5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Body weight changes after the diagnosis of endometrial cancer and their influences on disease-related prognosis

El‐Safadi

Sauerbier

Hackethal

et al. 2012

Arch Gynecol Obstet

Self Cite

View full text Add to dashboard Cite

Weight loss after the diagnosis and treatment of cancer may be an adverse prognostic factor. Although it was impossible to distinguish between intentional and non-intentional weight loss, these results argue against weight loss for risk reduction in patients with confirmed endometrial cancer. However, it may be reasonable regarding the risk reduction of non-cancer related morbidity and mortality. Detailed, prospective randomised trials are warranted.

show abstract

Influence of body mass index on prognosis in gynecological malignancies

Abstract: Although obesity increases the incidence of cancer, a high BMI does not seem to adversely influence the prognosis in patients with the mentioned gynecological malignancies.

Cited by 79 publications

References 36 publications

Obesity and Ovarian Cancer Survival: A Systematic Review and Meta-analysis

Obesity and Ovarian Cancer Survival: A Systematic Review and Meta-analysis

Feasibility and Safety of Laparoscopic Surgery for Obese Korean Women with Endometrial Cancer: Long-Term Results at a Single Institution

Body weight changes after the diagnosis of endometrial cancer and their influences on disease-related prognosis

Contact Info

Product

Resources

About