Body weight changes after the diagnosis of endometrial cancer and their influences on disease-related prognosis

El‐Safadi, Samer; Sauerbier, Anna; Hackethal, Andreas; Münstedt, Karsten

doi:10.1007/s00404-012-2224-7

Cited by 15 publications

(5 citation statements)

References 19 publications

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“…Some evidence indicates that intentional weight loss and prevention of weight cycling may reduce the risk of developing endometrial pathology [26]. However, other studies indicate that weight loss after the diagnosis of endometrial cancer may actually confer a worse prognosis [27]. Counseling at‐risk patients and encouraging diet, exercise, and lifestyle modifications could potentially attenuate the risk of endometrial pathology in addition to the many other obesity‐related comorbidities.…”

Section: Resultsmentioning

confidence: 99%

Management options and fertility‐preserving therapy for premenopausal endometrial hyperplasia and early‐stage endometrial cancer

Gressel

Parkash

Pal

2015

Intl J Gynecology & Obste

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Section: Resultsmentioning

confidence: 99%

Management options and fertility‐preserving therapy for premenopausal endometrial hyperplasia and early‐stage endometrial cancer

Gressel

Parkash

Pal

2015

Intl J Gynecology & Obste

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“…The consequences of weight loss for cancer survivors is a crucial issue in survivorship research. Observational studies have demonstrated associations between weight loss and increased risk of recurrence and higher all-cause mortality in several large cohorts of breast cancer survivors [ 34 – 36 ], with similar adverse effects reported in smaller samples of colorectal and endometrial cancer survivors [ 37 , 38 ]. In one study [ 34 ], associations between weight loss and mortality were stratified by weight status, and there was no evidence that weight loss was less harmful in the obese, although like the present study, there was no information on whether or not the weight loss was intentional.…”

Section: Discussionmentioning

confidence: 97%

The impact of a cancer diagnosis on weight change: findings from prospective, population-based cohorts in the UK and the US

et al. 2014

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BackgroundObesity is a risk factor for cancer incidence and survival, but data on patterns of weight change in cancer survivors are scarce and few stratify by pre-diagnosis weight status. In two population-based cohorts of older adults, we examined weight change in cancer survivors and cancer-free controls in relation to baseline weight status.MethodsIn the English Longitudinal Study of Ageing (ELSA) and the Health and Retirement Study (HRS), we identified participants diagnosed with cancer who had pre- and post-diagnosis BMI data (ELSA n = 264; HRS n = 2553), and cancer-free controls (ELSA n = 1538; HRS n = 4946). Repeated-measures ANOVAs tested three-way interactions by group (cancer/control), time (pre-/post-diagnosis), and pre-diagnosis weight status (normal-weight/overweight/obese).ResultsMean BMI change was -0.07 (SD = 2.22) in cancer survivors vs. +0.14 (SD = 1.11) in cancer-free controls in ELSA, and -0.20 (SD = 2.84) vs. +0.11 (SD = 0.93) respectively in HRS. Three-way interactions were significant in both cohorts (ELSA p = .015; HRS p < .001). In ELSA, mean BMI change in normal-weight cancer survivors was +0.19 (SD = 1.53) compared with -0.33 (SD = 3.04) in obese survivors. In ELSA controls, the respective figures were +0.09 (SD = 0.81) and +0.16 (SD = 1.50). In HRS, mean change in normal-weight cancer survivors was +0.07 (SD = 2.30) compared with -0.72 (SD = 3.53) in obese survivors. In HRS controls, the respective figures were +0.003 (SD = 0.66) and +0.27 (SD = 1.27).ConclusionOver a four-year period, in two cohorts of older adults, cancer survivors lost weight relative to cancer-free controls. However, cancer survivors who were obese pre-diagnosis were more likely to lose weight than healthy-weight survivors or obese adults without a cancer diagnosis. Whether this was due to differences in clinical status or deliberate lifestyle change triggered by the cancer diagnosis is not known. Further research is needed to establish why weight loss occurs more frequently in cancer survivors who were obese at diagnosis, and whether this has favourable effects on mortality.Electronic supplementary materialThe online version of this article (doi:10.1186/1471-2407-14-926) contains supplementary material, which is available to authorized users.

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“…Soliman et al reported that 58% of over 1500 women in an urban population were unaware that obesity increased the risk for endometrial cancer (9). Middle-aged cancer survivors additionally report low physical activity levels (10), and that two-thirds of oncology patients actually gain additional weight after diagnosis (11), demonstrating an opportunity for intervention in this particular patient population.…”

Section: Introductionmentioning

confidence: 99%

Obesity and Endometrial Cancer: A Lack of Knowledge but Opportunity for Intervention

Haggerty

Sarwer

Schmitz

et al. 2017

Nutrition and Cancer

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Objective: The causal link between obesity and endometrial cancer is well-established, however obese women’s knowledge of this relationship is unknown. Our objective was to explore patients’ understanding of this relationship and assess the acceptability of a technology-based weight loss intervention. Methods/Materials: Obese women with Type I endometrial cancer/hyperplasia were surveyed about their assessment of their body mass, knowledge of the relationship of obesity and endometrial cancer, and eating and activity habits. Interest in participation in an intervention also was assessed. Results: Eighty-one women with early stage (71.6% stage I) and grade (41.7% grade 1) disease completed the survey. The median BMI was 35.4 kg/m2 (IQR 32.2–43.5 kg/m2) and the average age was 59.3 (SD 11.1) years. 76.25% of women were unable to categorize their BMI correctly and 86.9% of those incorrectly underestimated their BMI category. One-third (35.9%) were unaware of any association between obesity and endometrial cancer and 33.3% responded that obesity decreased or did not significantly increase the risk of endometrial cancer. 59% expressed interest in a weight loss intervention. Conclusions: Endometrial cancer survivors with obesity underestimated their obesity and lacked knowledge regarding the link between obesity and endometrial cancer. However, the majority expressed interest in electronically delivered weight loss interventions.

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Body weight changes after the diagnosis of endometrial cancer and their influences on disease-related prognosis

Cited by 15 publications

References 19 publications

Management options and fertility‐preserving therapy for premenopausal endometrial hyperplasia and early‐stage endometrial cancer

Management options and fertility‐preserving therapy for premenopausal endometrial hyperplasia and early‐stage endometrial cancer

The impact of a cancer diagnosis on weight change: findings from prospective, population-based cohorts in the UK and the US

Obesity and Endometrial Cancer: A Lack of Knowledge but Opportunity for Intervention

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