Influence of Asiatic Acid, Madecassic Acid, and Asiaticoside on Human Collagen I Synthesis

Abstract

Asiatic acid, madecassic acid, and asiaticoside, terpenoids with an ursane skeleton, were tested separately and in combination on skin human fibroblast collagen I synthesis in vitro. In the absence of ascorbic acid, the mixture as well as each individual component stimulated collagen I synthesis to a similar extent. In the presence of ascorbic acid, the level of collagen I secretion was higher for each individual component and for the mixture. A comparison of asiaticoside and asiatic acid shows that the sugar moiety of the molecule does not seem to be necessary for this biological activity.

Factors affecting the content of pentacyclic triterpenes inCentella asiaticaraw materials

“…The aerial part of this plant possesses a wide range of pharmacological properties used for treating skin diseases and wounds (Farnsworth & Bunyapraphatsara, 1992) and for brain enrichment (promoting brain growth and improving learning and memory) (Subathra et al, 2005;Shinomol & Muralidhara, 2008;Zheng & Qin, 2007). Pentacyclic triterpenes, mainly, asiatic acid (1), madecassic acid (2), asiaticoside (3), and madecassoside (4) (Figure 1) are the active constituents that possess this variety of pharmacological activities, including stimulation of fibroblast proliferation and collagen synthesis (Bonte et al, 1994;Maquart et al, 1990;Lu et al, 2004), anti-inflammatory (Yun et al, 2008;Won et al, 2010), antiulcer (Cheng et al, 2004), antibacterial (Djoukeng et al, 2005) and anticancer (Park et al, 2005).…”

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“…H. zeylanica plays an important role in the wound healing process and protect tissues from oxidative damage. Wound healing mechanisms can be contributed to stimulate the production of antioxidants in wound site and provides a favorable environment for tissue healing [36] and wound healing effects can be due to up-regulation of human collagen I expression, [37] and an increase in tensile strength of the wounds.…”

Review of twelve West Africa medicinal plants: Active phytochemical combinations in direct biochemically wound healing process

“…The histologic study of the wound of the M. excelsa ointment treated rats showed more fibroblast proliferation and significant collagenization on day 14. These results obtained in the extract ointment treated group suggests that daily application of the ointment of M. excelsa promoted collagen expression (Bonte et al, 1993) , angiogenesis (Shukla et al, 1999) and tensile strength of the wounds (Suguna et al, 1996).…”