Influence of apolipoprotein(a) phenotype on lipoprotein(a) quantification: Evaluation of three methods

Leus, F.R.; Leerink, Casper B.; Prins, J. A.; Rijn, H. J. M. Van

doi:10.1016/0009-9120(94)00052-w

Cited by 15 publications

(7 citation statements)

References 26 publications

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“…Differences in the analytical methods used and the absence of standardization in Lp(a) measurement may have contributed to the uncertainty regarding Lp(a), CVD and FH [32]. The test used in this study is isoform‐dependent and is therefore known to underestimate the Lp(a) concentration of small apolipoprotein(a) [apo(a)] isoforms [33]. Small sized apo(a) is atherogenic and the level of apo(a) is elevated in FH patients with CVD compared with FH patients without CVD [34].…”

Section: Cardiovascular Risk Factorsmentioning

confidence: 99%

Prevalence and significance of cardiovascular risk factors in a large cohort of patients with familial hypercholesterolaemia

Nolting

Defesche

Buirma

et al. 2003

Journal of Internal Medicine

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Section: Cardiovascular Risk Factorsmentioning

confidence: 99%

Prevalence and significance of cardiovascular risk factors in a large cohort of patients with familial hypercholesterolaemia

Nolting

Defesche

Buirma

et al. 2003

Journal of Internal Medicine

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“…The blood samples from each subject were stored together and analyzed in one batch after the subject had completed the study. Apolipoprotein A was measured with a solid-phase, two-site immunoradiometric assay (Mercodia, Uppsala, Sweden), as described by Leus et al 22 The coefficients of variation within and between assays were 3.1 percent and 6.7 percent, respectively. The assay was calibrated against a highly purified, commercial Lp(a) lipoprotein preparation.…”

Section: Measurement Of Lipids and Lipoproteinsmentioning

confidence: 99%

Estrogen and Progestin Compared with Simvastatin for Hypercholesterolemia in Postmenopausal Women

et al. 1997

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“…Various function like Tissue Repair, Inhibition of fibrinolysis, Effect on Atherogenesis, Lp(a) particles are susceptible to oxidative modification and scavenger receptor uptake, leading to intracellular cholesterol accumulation and foam cell formation which contributes further to atherogenesis. 6,7 neovascularization atherosclerotic plaque thus contributing to angiogenesis. [11][12][13] The pathological effects due to increased Lp(a) was noticed when it exceeded 30 mg/dl.…”

Section: Introductionmentioning

confidence: 99%

“…[11][12][13] The pathological effects due to increased Lp(a) was noticed when it exceeded 30 mg/dl. 6,7 Reference plasma concentration of Lp(a) is around 15-20 mg/dl while in asian Indians it is around 30 mg/dl. [14][15][16][17][18] Increased serum Lp(a) is seen in both Type 1 and Type 2 Diabetic Patients.…”

Section: Introductionmentioning

confidence: 99%

A study on lipoprotein(a) in health and type-2 diabetes mellitus

Premkumar¹

2017

Int J Res Med Sci

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Background: Increased lipoprotein (a) [Lp (a)] concentrations are predictive of coronary artery disease (CAD). Type 2 diabetes mellitus also leads to dyslipidemia, which are known risk factors for CAD. This study was designed to investigate the levels of Lp (a) in type 2 diabetic patients and their association with healthy controls and glycemic control.Methods: The study included 87 subjects out of which 20 were healthy volunteers. The remaining 67 were patients with type 2 diabetes from which 3 groups were formed 23 formed newly diagnosed group while those on treatment for diabetes were 44 out of which 22 were type 2 diabetics on oral hypoglycemic agents and the other 22 were type 2 diabetics on insulin. Individuals suffering from HT, renal disease, liver disease, thyroid dysfunction, nephrotic syndrome & cardiac disease, alcoholics, smokers or on lipid lowering drugs were excluded. Statistical analysis was done using the pearsons correlation.Results: Lp(a) levels were found to be significantly increased in the diabetic group irrespective of whether newly diagnosed not on treatment or old cases on treatment with oral hypoglycemic agents or insulin. Lp(a) levels showed no correlation to the degree of glycemic control in these patients. Lp(a) positively correlates with total cholesterol, LDLc and negatively with TGL and VLDLc in diabetics while it does not correlate with any of the lipid parameters in controlsConclusions: The results of the present study suggest that Lp(a) levels are increased in type 2 diabetic patients. The elevated Lp(a) levels do not reflect the glycemic status and correlates with increase in total cholesterol and LDLc suggesting similar metabolic pathways and the genetic connection for LDL and Lp(a).

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Influence of apolipoprotein(a) phenotype on lipoprotein(a) quantification: Evaluation of three methods

Cited by 15 publications

References 26 publications

Prevalence and significance of cardiovascular risk factors in a large cohort of patients with familial hypercholesterolaemia

Prevalence and significance of cardiovascular risk factors in a large cohort of patients with familial hypercholesterolaemia

Estrogen and Progestin Compared with Simvastatin for Hypercholesterolemia in Postmenopausal Women

A study on lipoprotein(a) in health and type-2 diabetes mellitus

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